General Clinical Chemistry Analyzers and Accessories
Sartorius Octet AT Biosensor Transfer Tool, Ergonomic Design, Transfers 8 Biosensors, Research Use Only
The Sartorius Octet AT Biosensor Transfer Tool is an ergonomic device designed to enhance efficiency in biosensor transfer for Bio-Layer Interferometry (BLI). It allows the simultaneous transfer of eight biosensors, featuring a unique finger hook for improved stability and reduced user fatigue. This lightweight tool is compatible with the Sartorius Linear Pipette Stand, making workflows quicker and more efficient in research and bioprocessing environments.
Abcam Ezetimibe, cholesterol absorption inhibitor, 100MG
MW 409.4 Da, Purity >98%. Potent selective cholesterol absorption inhibitor. Inhibits cholesterol absorption in the intestine by preventing uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter. Ezetimibe reduces plasma cholesterol levels from 964 to 374 mg/dL, from 726 to 231 mg/dL, and from 516 to 178 mg/dL in the western, low-fat, and cholesterol-free diet mice, respectively.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Elvitegravir, quinolone HIV integrase inhibitor, 10MG
MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC₅₀ = 0.7 nM), HIV 2 EHO (IC₅₀ = 2.8 nM) and HIV-2 ROD (IC₅₀ = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC₅₀ range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GL x -351322, 5MG
MW 431.5 Da, Purity >=98%. GLX-351322 is a potent NADPH oxidase-4 (NOX-4) inhibitor. Displays selectivity for NOX-4 over NOX-2. GLX-351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells (IC₅₀ = 5 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Alvespimycin (17-DMAG) hydrochloride, 25MG
MW 653.2 Da, Purity >99%. A potent Hsp90 inhibitor (IC₅₀ = 62 nM), can bind to the ATP-binding motif and inhibit the protein chaperoning activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam G10, STING signaling activator, 1MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY2874455, FGF/FGFR inhibitor, 25MG
MW 444.3 Da, Purity >98%. Potent FGF/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC₅₀ < 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Furamidine dihydrochloride, 25MG
MW 304.3 Da, Purity >=98%. A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LM22A-4, neurotrophic BDNF mimetic, 50MG
MW 339.34 Da, Purity >98%. Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC₅₀ = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Amisulbrom
Chemical. CAS 348635-87-0. Formula C13H13BrFN5O4S2. MW 466.31. Synthetic. Oomycete-specific sulphonamide fungicide which acts by inhibiting mitochondrial complex III activity Complex III cytochrome bc1 ubiquinone reductase through binding to the Qi centre and impairing respiration and energy production. Categorized as quinine insider inhibitor QII. Shown to have anti-fouling activity. Compound can be used as analytical reference material.
AdipoGen S-Adenosylmethionine
Chemical. CAS 29908-03-0. Formula C15H22N6O5S. MW 398.44. S-Adenosylmethionine SAM is the first product of the methionine cycle and is implicated in the synthesis of polyamines and in the transsulfuration pathway leading to homocysteine and reduced glutathione GSH biosynthesis. SAM is synthesized from methionine and ATP in a reaction catalyzed by methionine adenosyltransferases MATs. These enzymes are encoded by two genes, MAT1A and MAT2A. SAM plays an essential role as methyl-donor for the methylation reactions during which it is transformed to S-adenosylhomocysteine SAH. SAH, a strong inhibitor of transmethylations, is transformed to homocysteine HCY by a specific hydroxylase. The methionine cycle plays a fundamental role in the cellular metabolism and the alteration of its functionality causes important disorders linked to modification of DNA methylation and gene expression, redox imbalance and metabolic reprogramming in liver and brain.
Rarecyte RareCyte AccuCyte Blood Separation Kit, 10-Pack
Individually packed components for processing ten blood samples. Components include: AccuCyte Blood Separation Tube with Cap, AccuCyte Float 1.055 - 1.058, AccuCyte Collector with Waste Tube, Isolation Tube with Septum Bottom, AccuCyte CyteSeal Brass Sealing Ring, AccuCyte Locking Clip and a grey CyteSpreader Blade.
Echelon Biosciences Research Labs MEMBRANE LIPID ARRAYS 2 pack
Membrane Lipid Arrays are 4 x 5 cm hydrophobic membranes that have been spotted with a concentration gradient of eight different biologically important lipids found in cell membranes. They are used to determine the relative degree of binding of your protein of interest towards one or more of these lipids in a simple protein lipid overlay assay. Bound protein is then detected by an antibody against the protein or affinity tag. This item is non returnable