Custom Peptides
Cayman Chemical ClInofIbrate 10mg
A hypolipidemic agent; inhibits HMG-CoA reductase (IC50 = 0.47 mM); stimulates the S-indan-1-ol dehydrogenase activity of human liver AKR 1C4; reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source at 10 and 30 mg/kg
Cayman Chemical 5-fluoro 203 10mg
A cytotoxic compound that at 1 µM activates aryl hydrocarbon receptor signaling, inducing transcription of cytochrome P450 1A1, which leads to the formation of DNA adducts and cell cycle arrest; can increase the levels of ROS as well as activate JNK, ERK, and p38MAPK in certain ovarian, breast, kidney, and colorectal cancer cells
Genelink Random Hexamers, 100 μg, 6 bases, 5'-d(NNNNNN)-3', Equimolar 25% A, C, G, T, ~54 nmol/molecule, HPLC purified
Random Hexamers (100 μg) from GENELINK are a versatile mixture of oligonucleotides, six bases in length, designed for a range of molecular biology applications. These primers are crucial for processes like DNA probe labeling, first-strand cDNA synthesis, and the detection of genetic variations. The random nature of the sequence allows for extensive coverage of target DNA or RNA templates, making them ideal for numerous genomic studies.
- Facilitates DNA probe labeling, cDNA synthesis, and RAPD analysis.
- Enables production of high specific activity labeled DNA probes for sensitive detection.
- Provides random initiation sites across varied RNA templates.
- Supports identification of genetic variations for genetic mapping.
Cayman Chemical 3FluoromethamphetamInhydr 10mg
An isomer of 4-FMA characterized by having fluorine at the 3 position of the phenyl group; intended for forensic and research applications
Cayman Chemical 6 6DImethyl3 4methylbenzo 10mg
A GLP-1R positive allosteric modulator; increases GLP-1-induced cAMP production by 268.35% in a reporter assay using HEK293 cells expressing human GLP-1R; induces insulin secretion in glucose-stimulated GLP-1 (7-36)-induced INS-1 832/13 cells at 5 µM; decreases blood glucose levels in a glucose tolerance test in fasted mice at 10 or 30 mg/kg
Cayman Chemical 5 7DIchLRokynurenIc AcId 10mg
An NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay); selectively selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors; reduces NMDA-induced neurotoxicity in primary rat cortical neurons from 1 to 10 μM; reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner from 0.97-97 nmol; blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the PVN in anesthetized rabbits; increases social interaction time and time spent in the open arms of the elevated plus maze; disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm
Cayman Chemical Cudetaxestat 10mg
An autotaxin inhibitor (IC50 = ≤0.5 µM); reduces MDA-MB-435 cell migration (IC50 = 15 nM); reduces blood glucose levels in a glucose tolerance test, as well as baseline blood glucose levels, in mice fed a high-fat diet at 15 mg/kg twice per day for two days; reduces liver fibrosis in a CDAA/HFD mouse model of liver fibrosis at 10 mg/kg; reduces colon ulcer area and increases colon length in mouse models of acute and chronic ulcerative colitis, respectively
Cayman Chemical W-MurIcholIc AcId 10mg
A murine-specific secondary bile acid; formed via enzymatic conversion of β-MCA by a variety of intestinal microorganisms in rat and mouse gut
Cayman Chemical PSB-1115potasIum salt 10mg
An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical ApraclonIdInhydrochlorIde 10mg
An α2-AR agonist; binds to α2-AR in calf cortex, rat kidney, and rat spleen (IC50s = 0.9, 4.3, and 4.2 nM, respectively); binds to α2-AR in rat cerebral cortex membrane, pig submandibular gland and lung tissue, and dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively); inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively)
Cayman Chemical Peficitinib 10MG
A JAK inhibitor (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively); 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays; inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC50s = 124 and 127 nM, respectively); reduces paw swelling (ED50 = 5.6 mg/kg) and bone destruction in a rat model of adjuvant-induced arthritis at 30 mg/kg
Cayman Chemical Chromn 1hydrochLRIde hydr 10mg
A ROCK2 inhibitor (IC50 = 50s = 1,740 and 127 nM, respectively); inhibits phosphorylation of MLC in a cell-based assay (IC50 = <4 nM)
Cayman Chemical SAAP 148trIfluoROCTAte sa 10mg
An antimicrobial peptide; active against several multidrug-resistant bacteria in vitro; decreases the number of skin CFUs in mouse models of A. baumannii or MRSA infections at 0.125-2% w/w
Cayman Chemical AcetoxyvalerenIc AcId 10mg
A sesquiterpenic acid; cytotoxic to GLC-4 and COLO 320 cells (IC50s = 111 and 124 µM, respectively)