Custom Peptides
Cayman Chemical IsorhamntIn-3-OD-GlucosId 10mg
A flavonoid glycoside with diverse biological activities; scavenges DPPH and ABTS radicals in cell-free assays (IC50s = 3.16 and 44.93 UG/ml, respectively); inhibits H. contortus egg hatching and larval development (EC50s = 431.5 and 55.61 UG/ml, respectively); induces lethality in C. elegans (EC50 = 342 UG/ml); inhibits rat lens aldose reductase (IC50 = 0.75 UG/ml) and reduces sorbitol accumulation in lenses, red blood cells, and sciatic nerve in a rat model of STZ-induced diabetes
Cayman Chemical DchIroInosItol 1234 5 6 10mg
A stereoisomer of IP6; identified in soil samples from Madagascar, New Zealand, and the Falkland Islands and in freshwater sediment from Danish lakes
Cayman Chemical Psoala coylfola Bakucol 10mg
A natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM)
Cayman Chemical MJ33lIthIum salt 10mg
A selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%; blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells
Cayman Chemical AMPR22trIfluoroACTAte sal 10mg
An antimicrobial peptide; active against S. aureus, MRSA, P. aeruginosa, and carbapenem-resistant P. aeruginosa (MBCs = 2, 2, 2, and 4 UG/ml, respectively); induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa; increases survival in a mouse model of sepsis induced by S. aureus at 10 mg/kg
Cayman Chemical Cardol trIen 10mg
A phenol from cashew nut shell liquid; inhibits mushroom tyrosinase (IC50 = 2.2 µM); kills 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 µM, respectively; has been used as a starting material for the synthesis of bis-benzoxazines
Cayman Chemical E6446hydrochlorIde 10mg
A TLR7 and TLR9 antagonist (IC50s = 1.78 and 0.01 µM, respectively); selective for TLR7 and TLR9 over TLR4 (IC50 = 10.58 µM); inhibits CpG ODN2216- or RNA40-induced IL-6 production in isolated mouse BMDCs; prevents increases in left ventricle chamber size and cardiac fibrosis in a mouse model of transverse aortic constriction-induced heart failure at 1.5 mg/animal; increases survival and reduces increases in right ventricular systolic pressure and hypertrophy in a rat model of monocrotaline-induced pulmonary hypertension at 10 mg/kg; has been used to enhance the transfection efficiency of cell-penetrating peptides for the delivery of mRNA in vitro
Cayman Chemical Cyprus rotundus aCypron 10mg
A sesquiterpenoid with diverse biological activities; inhibits LPS-induced nuclear translocation of p65, as well as LPS-induced production of PGE2 and IL-6, in RAW 264.7 cells; reduces hydrogen peroxide-induced production of ROS and apoptosis in SH-SY5Y cells at 15 and 30 µM; reduces the production of HBsAG in infected HepG2.2.15 cells (IC50 = 274.7 µM)
Cayman Chemical JWH 122 N 4pentenyl nalog 10mg
Structurally related to JWH 122, differing only by the presence of a terminal double bond on the acyl chain; intended for forensic and research applications
Cayman Chemical BzNleKRRAMChydrochlorIde 10mg
A fluorogenic substrate for YFV NS3 or DV NS2B/3 serine proteases; AMC is released upon enzymatic cleavage by YFV NS3 or DV NS2B/3 serine proteases and its fluorescence can be used to quantify YFV NS3 or DV NS2B/3 serine protease activity; ex/em = 340-360/440-460 nm, respectively
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Human & Mouse Total ATF2 Detection Kit, 500 Assay Points
AlphaLISA SureFire Ultra Human & Mouse Total ATF2 Detection Kit, 500 Assay Points
Cayman Chemical SInfungIntrIfluoroacetate 10mg
A purine nucleoside with diverse biological activities; inhibits G9a and SET7 (IC50s = 10.4 and 2.38 µM, respectively, using histone H3 (1-21) peptide as a substrate and IC50s = 150 and 9.1 µM, respectively, using full-length histone H3 as a substrate); inhibits PRMT5 (IC50s = 0.31 and 0.69 µM using histone H4 (1-21) peptide and full-length histone H4, respectively, as substrates); reduces renal fibrosis and H3K4me1 levels in a mouse model of unilateral ureteral obstruction at 10 mg/kg
Cayman Chemical ChromomycIn A3 10mg
A fluorescent probe and antitumor agent; displays ex/em of 445/575 nm; specifically binds GC base pairs on DNA; can be used to characterize heterochromatin in plants; cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively); inhibits oxidative stress- and DNA damage-induced neuronal injury
Cayman Chemical JNJ47117096trIfluoroACTAt 10mg
A MELK inhibitor (IC50 = 37 nM); selective for MELK over CAMKIIδ, MNK2, CAMKIIγ, and MLCK (IC50s = 810, 760, 1,000, and 1,000 nM, respectively) but does inhibit FLT3 (IC50 = 18 nM); inhibits MELK autophosphorylation (IC50 = 0.52 µM) and MELK proteasome-dependent degradation in MCF-7 cells; induces cellular senescence and the ATM-mediated DNA damage response in MCF-7 cells
Cayman Chemical SwertIamarIn 10mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day