Custom Peptides
Cayman Chemical CHIR99021hydrochlorIde 10mg
An aminopyrimidine derivative that inhibits GSK3α and GSK3β (IC50s = 10 and 6.7 nM, respectively); activates glycogen synthesis in CHO-IR cells (EC50 = 0.763 μM) and in isolated type 1 diabetic rat skeletal muscle; has been shown to promote self-renewal of embryonic stem cells
Cayman Chemical Coydals duls max. Coydn 10mg
An aporphine alkaloid with diverse biological activities; inhibits the proliferation murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells from 10-100 UG/ml; binds to μ-opioid receptors (Ki = 2.82 µM) and induces [35S]GTPγS binding in CHO cells expressing human μ-opioid receptors (EC50 = 0.51 µM); active against L. donovani promastigotes (IC50 = 26.7 µM)
Cayman Chemical QuInaprIlat 10mg
An ACE inhibitor (IC50 = 0.06 nM) and active metabolite of quinapril; inhibits LPC-induced calcium overload and rod to round cell shape change in isolated rat cardiomyocytes at 20 and 50 µM; reduces the frequency of ventricular fibrillation in a dog model of myocardial ischemia and reperfusion injury at 3 UG/kg; reduces blood pressure and proteinuria in rat models of uranyl nitrate- or 5/6 nephrectomy-induced chronic renal failure at 0.1 mg/kg
Cayman Chemical 2-ThIocytIdIn 10mg
A modified nucleobase; an intermediate in the synthesis of pyrimidine β-ribonucleosides and β-ribonucleotides
Cayman Chemical GBR 12783hydrochlorIde 10mg
A dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes); selective for inhibition of dopamine uptake over norepinephrine or 5-HT uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively); improves learning and memory in the passive avoidance test in rats at 10 mg/kg, i.p., an effect that can be blocked by scopolamine; increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice; inhibits haloperidol-induced catalepsy in rats at 10 mg/kg
Cayman Chemical L-Tryptophn-d5 10mg
An internal standard for the quantification of L-tryptophan by GC- or LC-MS
Cayman Chemical Chromn 1hydrochLRIde hydr 10mg
A ROCK2 inhibitor (IC50 = 50s = 1,740 and 127 nM, respectively); inhibits phosphorylation of MLC in a cell-based assay (IC50 = <4 nM)
Cayman Chemical 2-PhenylmelatonIn 10mg
A MT receptor mixed partial agonist and antagonist; selective for MT1 and MT2 receptors (Kis = 0.02 and 0.09 nM, respectively, in HEK293 cells expressing the human receptors) over the MT3 receptor (Ki = 33 nM in hamster brain membranes); induces [35S]GTPγS binding to NIH3T3 cell membranes expressing the human MT2 receptor (EC50 = 0.058 nM); induces contractions (EC50 = 0.5 nM) and inhibits melatonin-induced contractions in isolated guinea pig proximal colon strips at 0.1 nM; reduces intraocular pressure in rabbits (pD2 = 8.7)
Cayman Chemical QuInacrIn mustardhydroCLO 10mg
A fluorescent DNA-intercalating agent; selectively binds to AT base pairs over GC base pairs; has been used to label metaphase chromosomes for karyotyping by autoradiography
Cayman Chemical L-Valn-d8 10mg
An internal standard for the quantification of L-valine by GC- or LC-MS
Cayman Chemical ThIocolchIcosIde 10mg
A GABAA receptor antagonist; inhibits GABAA receptor mediated currents in Purkinje cells isolated from rat cerebellum (IC50 = 0.15 µl); binds strychnine-sensitive glycine receptors in isolated rat spinal cord (IC50 = 1.58 µM); inhibits cell growth in a panel of cancer cell lines at 25-100 µM; inhibits anti-apoptotic proteins Bcl-2, XIAP, Mcl-1, Bcl-xL, cIAP-1, and cIAP-2 in KBM5 cells; inhibits TNF-α-induced NF-κB activation and IκBα degradation in KBM5 cells
Cayman Chemical Astoloca mnsuns Astolon 10mg
A sesquiterpene with anticancer activity; cytotoxic to H460, ES-2, and DU145 cells (IC50s = 51.3, 61.5, and 58 UG/ml, respectively)
Cayman Chemical MoexIprIlat 10mg
An ACE inhibitor and active metabolite of the prodrug moexipril (IC50 = 2.1 nM); prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts at 10 nM; reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide in ovariectomized mice at 50 mg/kg per day