Custom Peptides
Cayman Chemical KIspeptIn234trIfluoroacet 10mg
A peptide kisspeptin receptor antagonist; inhibits kisspeptin-10-induced inositol phosphate production in CHO cells expressing the human kisspeptin receptor (IC50 = 7 nM) and kisspeptin-10-induced firing of isolated mouse GnRH neurons; inhibits pulsatile GnRH secretion in pubertal female rhesus monkeys; inhibits kisspeptin-10-induced luteinizing hormone secretion in adult male rats and mice
Cayman Chemical Forsytha fructus Phlyrn 10mg
A lignan with diverse biological activities; reduces hydrogen peroxide-induced caspase activation, increases in MDA levels, and production of ROS, as well as increases GPX and SOD activities in PC12 cells; active against P. aeruginosa in vitro (MIC = 0.5 mg/ml); increases survival in a C. elegans model of P. aeruginosa infection; intragastric administration reduces pulmonary NF-κB activation, neutrophil infiltration, and levels of TNF-α, IL-1β, and IL-6, as well as interstitial edema in a mouse model of LPS-induced acute lung injury at 10 and 20 mg/kg; decreases body weight, hepatic total cholesterol, free fatty acid, and triglyceride levels, and serum insulin levels in obese mice; prolongs survival time, decreases viral titers, and attenuates pulmonary tissue damage in a mouse model of influenza A infection at 20 mg/kg
Cayman Chemical EIcosapentaenyl EthnlamID 10mg
An N-acylethanolamide that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes; also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide
Cayman Chemical Esmolol AcIdhydrochlorIde 10mg
An active metabolite of esmolol; inhibits isoproterenol-induced increases in the beating rate of isolated guinea pig right atria (pA2 = 3.73); prevents isoproterenol-induced tachycardia and hypotension in anesthetized dogs; a potential impurity in commercial preparations of esmolol
Cayman Chemical BenzamIlhydrochlorIde 10mg
An ENaC blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles; an NCX blocker that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 ~ 100 nM); an inhibitor of TRPP3 (IC50 = 1.1 μM)
Cayman Chemical PDMPhydrochlorIde 10mg
A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1,4-galactosyltransferase 6, however, the inhibitory activity on both enzymes is attributed to the D-threo enantiomer; enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro
Cayman Chemical DMAPPamonIum salt 10mg
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.{6606,6607} Farnesylation is essential for the function of a number of proteins involved in signal transduction.{5456,2640}
Cayman Chemical Butenoyl PAF 10mg
A product of the oxidative decomposition of 2-arachidonoyl phospholipids; 10-fold less potent than PAF as a PAF receptor agonist, but present in amounts 100-fold greater
Cayman Chemical DL-4662hydrochlorIde 10mg
A 3,4-dimethoxy derivative of the substituted cathinones: pentedrone and α-PVP that also features an ethylamine in place of the amino group that is typically attached to the alpha carbon of pentedrone; intended for forensic and research purposes
Cayman Chemical 2Omethyl PAF C18hydrAT 10mg
A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position; decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS
Cayman Chemical GncIclovIrsodIum salt 10mg
An active metabolite of valganciclovir and an antiviral nucleoside derivative; reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM); topical application decreases disease severity and corneal leukocyte infiltration in a cat model of ocular FHV-1 epithelial infection at 0.15%; prevents allograft histologic injury and NK and myeloid cell infiltration in a mouse model of murine CMV infection with renal transplantation at 15 mg/kg; induces tumor regression in a K-BALB murine sarcoma model using a mixed population of HSV TK positive or negative cells
Cayman Chemical DeACtylaspRulosIdIc AcId 10mg
A monoterpene glycoside with antioxidant activity; decreases serum malondialdehyde levels and increases superoxide dismutase activity in rats at 30 and 50 mg/kg per day for seven days
Cayman Chemical Eprosartnmesylate 10mg
A competitive AT1 receptor antagonist (IC50s 1.4 – 3.9 nM and an elimination half-life of 5 to 7 hours) that blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels
Cayman Chemical 17phenyl trInor PrstglndI 10mg
17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.{3318,1025} 17-phenyl trinor PGE2 is an EP1 and EP3 receptor agonist.1,2 It causes contraction of the guinea pig ileum at a concentration of 11 µM.{3318} It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.{1025} With an ED50 value of 350 UG/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.{1025}
Cayman Chemical Fmoc-Glu OtBu-OSu 5g
An amino acid-containing building block; used in the synthesis of bis- and tris-branched carboxyl group-terminal PEGylating reagents; has been used in the synthesis of N3S chelators