Custom Peptides
Cayman Chemical RalmItaront 10mg
A TAAR1 agonist; induces cAMP accumulation in HEK293T cells expressing human TAAR1 (EC50 = 17.78 nM)
Cayman Chemical Cefmetazole 10mg
A cephamycin antibiotic; active against E. coli, P. mirabilis, H. influenzae, N. gonorrhoeae, S. pneumoniae, and S. pyogenes (MIC50s = 0.25-2 μg/ml); decreases the lesion size and the number of ulcerative lesions in a rabbit model of active syphilis at 20 and 40 mg/kg per day
Cayman Chemical O6-BenzylgunIn 10mg
A guanine analog with antineoplastic activity; irreversibly inactivates AGT, with 40% reduction in alkyltransferase activity achieved at 0.06 µM with recombinant human AGT; effective in vivo as well as in vitro
Cayman Chemical D- CItramalIc AcIdlIthIu 10mg
A biochemical intermediate involved in the anaerobic metabolism of glutamate through the methylaspartate pathway of C. tetanomorphum; also plays various roles in other aspects of bacterial metabolism
Cayman Chemical 21-desacetyl Deflazacort 10mg
The active glucocorticoid derived from the prodrug deflazacort
Cayman Chemical 14-DeoxyndrographolIde 10mg
A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 UG/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model
Cayman Chemical CPTH6hydrobromIde 10mg
A thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP; blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines
Cayman Chemical BretylIumtosylate 10mg
A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs, as well as increases action potential delay and the absolute refractory period in isolated mouse vas deferens sympathetic nerve terminals
Cayman Chemical RhodaMN dIthenyl hydrazID 10mg
A fluorescent and colorimetric probe for the detection of ferric iron; fluoresces upon iron binding; ex/em = 534/550-700 nm; emits fluorescence at 588 nm in the presence of ferric iron but not ferrous iron or in a panel of 11 additional cations and 10 anions; exhibits a visual shift from colorless to pink upon addition of ferric iron to aqueous solutions or live cells, which can be detected colorimetrically
Cayman Chemical CalcItonInel 10mg
A peptide hormone that lowers blood calcium levels and inhibits bone resorption; binds to CTR2 with higher affinity than human, porcine, or rat calcitonin (Kis = 0.01, 2.95, 0.44, and 5.89 nM, respectively, in radioligand binding assays); inhibits gastric emptying more potently than human calcitonin in conscious dogs at 10 UG/kg; increases the paw withdrawal threshold in a mouse model of carrageenan-induced inflammation at 0.2 UG/paw
Cayman Chemical DIoctnoyl Glycol 10mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical 2 5-dIdeoxy AdenosIn 10mg
A cell-permeable, P-site inhibitor of adenylate cyclase; inhibits forskolin-induced activation of a cAMP-dependent reporter gene in HEK293 cells with an IC50 value of 33 µM
Cayman Chemical SynthetIc CIrsIlIol 10mg
A flavonoid with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 0.1 and 1 µM, respectively); inhibits release of SRS-A in passively sensitized isolated guinea pig lung (IC50 = 0.4 µM); induces relaxation of isolated precontracted rat uterus, urinary bladder, proximal aorta, and trachea; inhibits colony formation and migration of B16/F10 murine melanoma cells; enhances radiation-induced inhibition of tumor growth in an H1299 NSCLC mouse xenograft model at 200 UG/kg
Cayman Chemical HexnoIc AcId-d5 10mg
An internal standard for the quantification of hexanoicacid by GC- or LC-MS
Cayman Chemical ElIglustathemItartrate 10mg
A glucosylceramide synthase inhibitor (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells); selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all); decreases GM1 and GM3 cell surface levels in K562 and B16/F10 cells (IC50s = 24 and 29 nM, respectively); decreases glucosylceramide levels in the liver and lungs of D409V/null mice