Custom Peptides
Cayman Chemical ML-133hydrochlorIde 10mg
A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal
Cayman Chemical OmapatrIlat 10mg
An orally bioavailable ACE and NEP inhibitor (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes); inhibits the angiotensin I-induced pressor response in normotensive rats (ED50 = 0.07 µmol/kg); lowers MAP in sodium-depleted spontaneously hypertensive rats at 30 µmol/kg; lowers MAP in rats when co-administered with bradykinin; increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner
Cayman Chemical PropIophenon 10mg
An analytical reference standard categorized as a precursor in the synthesis of cathinones; intended for research and forensic applications
Cayman Chemical Atenolol 10mg
An enantiomer of (±)-atenolol; inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (Ki = 8.61 µM); has no effect on blood pressure in spontaneously hypertensive rats
ABclonal Technology Phospho-IRAK4-Ser346
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways The protein is essential for most innate immune responses Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease Multiple transcript variants encoding different isoforms have been found for this gene
Cayman Chemical HeptadecnoylLcarnItInd3 10mg
An internal standard for the quantification of heptadecanoyl-L-carnitine by GC- or LC-MS
Cayman Chemical 4-MAPBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; intended for research and forensic applications
Cayman Chemical SalvInolIc AcId B 10mg
An antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties
Cayman Chemical MecamylamInhydrochlorIde 10mg
A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM)
Cayman Chemical 4-fluoro PV9hydrochlorIde 10mg
Differs from PV9 by having a fluorine atom at the four, or para, position of the phenyl group
Cayman Chemical L-3-n-ButylphthalIde 10mg
A phthalide with antiplatelet and neuroprotective activities; inhibits ADP-, collagen-, and arachidonic acid-induced platelet aggregation ex vivo at 3-100 mg/kg; inhibits thrombus formation in a collagen and epinephrine-induced rat model of experimental thrombosis; reduces amyloid-β-induced decreases in GPX activity and decreases MDA levels in the cortex and hippocampus and improves spatial learning and memory in the Morris water maze in a rat model of Alzheimer’s disease induced by i.c.v. infusion of amyloid-β (1-40)
Cayman Chemical mK1trIfluoroacetate salt 10mg
An FPR2 agonist; induces calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = α16 alone or in combination with FPR1 (EC50s = >10,000 nM for both); induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner; increases production of IL-1β and IL-6 in isolated human monocytes at 10 µM
Cayman Chemical 7methoxy ApIgenInIdInCLOr 10mg
A 3-deoxyanthocyanin; active against radial growth of G. sorghi and spore germination of P. oryzae (IC50 = 50 ppm for both)
Cayman Chemical CyclosporIn B 10mg
A fungal metabolite with diverse biological activities; inhibits the growth of T lymphoma cells in a concentration-dependent manner; inhibits P-gp activity in vitro (IC50 = 4.7 μM)
Cayman Chemical NorgestImate 10mg
A progestin; prodrug form of norelgestromin and levonorgestrel; binds to progestin receptors (mean IC50 = 3.48 nM for rabbit uterine receptors) and is selective for progestin over androgen receptors (mean IC50 = 764 nM for rat prostatic receptors); maintains pregnancy in ovariectomized female rats in a dose-dependent manner; inhibits ovulation in 100% of female rats at 0.5 mg/kg; completely inhibits estrone-induced vaginal cornification in ovariectomized female rats at 2 mg/kg, indicating antiestrogenic activity