Custom Peptides
Cayman Chemical 1Stearoyl2Oleoylsnglycer 10mg
A phospholipid; has been used in the generation of LNPs for in vitro delivery of mRNA or nuclear-targeted plasmid DNA
Cayman Chemical DehydrolIthocholIc AcId 10mg
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM
Cayman Chemical N-ArachIdonylAmInobutyrIc 10mg
Several different arachidonoyl amino acids, including NAGABA, have been isolated and characterized from bovine brain. The glycine congener (NAGly) was found to suppress formalin-induced pain in rats. NAGABA also suppresses normal responses to pain, but has not yet been fully characterized.
Cayman Chemical Boc-Glu-OBzl 1g
An amino acid building block; has been used in the synthesis of peptide-based inhibitors of human caspases and HRV 3C protease that have enzyme inhibitory activity in vitro
Cayman Chemical OctahydrocurcumIn 10mg
An active metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 12.3 µM); inhibits LPS-induced increases in iNOS and COX-2 levels, production of NO, and nuclear translocation of NF-ᴋB in RAW 264.7 cells at 6.25 µM; active against various bacteria and fungi in disc assays; increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model at 5, 10, and 20 mg/kg
Cayman Chemical Bluma balsamfra Blumatn 10mg
A flavonoid with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (SC50 = 90.8 UG/ml); decreases carbon tetrachloride-induced lipid peroxidation in isolated rhesus monkey hepatocytes; cytotoxic to KB oral carcinoma cells (IC50 = 47.72 UG/ml)
Cayman Chemical Isocurcumenol 10mg
A sesquiterpene with diverse biological activities; inhibits LPS-induced production of NO in isolated mouse peritoneal macrophages; reduces LPS/D-galactosamine-induced increases in serum levels of GOT and GPT in a mouse model of liver injury at 50 mg/kg
Cayman Chemical PlatycodIn D 10mg
A saponin isolated from the root of P. grandiflorum, which has been used extensively in Chinese herbal medicine for many applications
Cayman Chemical 5-trns ProstaglndIn F2a 10mg
5-trans PGF2α is the more thermodynamically stable C-5 olefin isomer of PGF2α and is a common impurity in commercial lots of PGF2α. 5-trans PGF2α administered intravenously to anesthetized rabbits caused a substantial (ten-fold) increase in respiratory rate, but this attribute was common to a number of F-series compounds and analogs.{2224}
Cayman Chemical ABCHMINACA metabolIte M1A 10mg
A monohydroxylated metabolite of AB-CHMINACA; intended for forensic and research applications
Cayman Chemical Carbaprostacycln mthyl St 10mg
A more lipid soluble form of carbaprostacyclin; may more readily enter cells to activate PPARδ; may be more amenable for dietary formulations
Cayman Chemical C4 CeramIded18 14 0 10mg
A bioactive sphingolipid; inhibits IL-4 production by 16% in PMA-stimulated EL4 T cells at 10 μM; cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively); increases maturation and stability of F508del-CFTR proteins, enhances cAMP-activated chloride secretion, and suppresses secretion of IL-8 in primary epithelial cells isolated from patients with cystic fibrosis
Cayman Chemical TetrahydroberberIn 10mg
An isoquinoline alkaloid; inhibits iron- and ascorbate-induced lipid peroxidation in rat liver microsomes (IC50 = 13.7 µM); binds to D2 and 5-HT1A receptors (Kis = 0.83 and 4.2 µM, respectively); inhibits ACh-induced potassium currents in primary rat hippocampal CA1 pyramidal neurons (IC50 = 13 µM); stimulates mouse C12C12 myoblast differentiation