Custom Peptides
Cayman Chemical IBTPIodIde 10mg
A lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner
Cayman Chemical AS-605240potasIum salt 10mg
An orally active inhibitor of PI3-kinase γ that suppresses joint inflammation in mouse models of rheumatoid arthritis; inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively
Cayman Chemical 2heptyl3hydroxy4 1HQuIn 10mg
A quorum-sensing signal molecule produced by P. aeruginosa in response to increasing cell density; increases expression of the lasB gene, which encodes the virulence factor elastase, in P. aeruginosa (EC50 = ~30 µM in a reporter cell assay); increases secretion of pyocyanin and PA-IL, as well as increases biofilm production in P. aeruginosa populations at 60 µM; an iron chelator in P. aeruginosa growth media at 40 µM
Cayman Chemical MetIprnolol 10mg
A β-AR antagonist; binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM); inhibits isoproterenol-induced relaxation in guinea pig atrium and fenoterol-induced relaxation in rat uterus (pA2s = 8.3 and 8.4, respectively); inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates (100 μM); decreases α-chymotrypsin-induced increases in IOP in rabbits when administered topically to the eye at a dose of 0.3%; inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%
Cayman Chemical AromadendrIn 10mg
A flavone with diverse biological activities; scavenges DPPH radicals (IC50 = 2.21 µM) and inhibits AChE (IC50 = 35.43 µM), but not BChE and BACE1 (IC50s = >200 µM), in cell-free assays; inhibits the growth of BT474, ChaGo-K-1, HepG2, KATO-III, and SW620 cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 µM, respectively); prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells; reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis
Cayman Chemical RupIntrIvIr 10mg
An inhibitor of HRV 3C protease; inhibits HRV 3C protease-induced proteolysis of HRV-14 precursor polyproteins in HRV-14-infected H1HeLa cells at 2 µM; inhibits replication of 49 serotypes of HRV in HRV-infected H1HeLa cells (mean EC50 = 0.023 µM); inhibits replication of coxsackievirus 21, coxsackievirus B3, echovirus type 11, and enterovirus 70 in virus-infected MRC-5 cells (EC50s = 0.147, 0.183, 0.014, and 0.007 µM, respectively); decreases the number of HRV-2 PFUs in, and IL-8 and IL-6 secretion by, HRV-2-infected BEAS-2B cells at 10 µM; inhibits enterovirus 71-induced limb paralysis and decreases in survival, as well as reduces intestinal, lung, brain stem, and cardiac muscle viral loads, in enterovirus-71-infected neonatal mice at 0.1 mg/kg per day
Cayman Chemical OxytocInacetate 10mg
A nonapeptide hormone primarily synthesized in the hypothalamus with roles in uterine contraction and lactation, social memory and attachment, sexual and maternal behavior, aggression, learning, anxiety, feeding, and pain perception
Cayman Chemical NDT 9513727 10mg
A competitive antagonist of C5aR (IC50 = 11.6 nM for the human recombinant receptor); has inverse agonist activity; selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 µM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively); inhibits degranulation in C5a-stimulated U937 cells (IC50 = 7.1 nM); prevents C5a-induced neutropenia in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques at 5 and 25 mg/kg
Cayman Chemical 4Methyl7 4nItro2 trIflu 10mg
A turn-on fluorescent probe for H2S; excited at 348 nm in DMSO and fluorescence intensity increases in the presence of HS-; selective for HS- over cysteine, AcO-, F-, H2PO4-, Cl-, Br-, and I- and is not cytotoxic up to a concentration of 150 UG/ml
Cayman Chemical 3-keto SphngnInd18 0h 10mg
An intermediate in the biosynthesis of C18 ceramide; a lyso-sphingolipid formed by the condensation of L-serine and palmitoyl-CoA by SPT; vitamin K deficiency decreases production by SPT
Cayman Chemical 2HChoArgtrIfluoroacetAT 10mg
A steroid-based cationic lipid that can be used to facilitate gene transfection; forms a complex with pDNA and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher; facilitates transfection of the luciferase gene into H1299 cells, which can be inhibited by methyl-β-cyclodextrin and genistein; induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml)
Cayman Chemical 1PalmItoyl2ArachIdonylsn 10mg
A phospholipid; has been found in egg yolk and isolated rat retina
Cayman Chemical OctacosnoIc ACD mthyl Ste 10mg
A very long-chain fatty acid methyl ester; has been found in transesterified palm oil, biodiesel produced by the microalga Botryococcus, and in sediment samples from Lake Kivu in the EAst African rift valley
Cayman Chemical PorcupIn-IN-1 10mg
An inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays); inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells at 0.1 μM, indicating inhibition of porcupine