Custom Peptides
Cayman Chemical Phylnthus urnara Grn 10mg
A tannin with diverse biological activities; scavenges DPPH (IC50s = 0.92 and 1.27 μM at pH 4.5 and 7.9, respectively), superoxide (IC50 = 2.65 μM), and hydroxyl radicals (IC50 = 1.44 μM) in cell-free assays; inhibits HSV-1 and HSV-2 replication in plaque reduction assays (IC50s = 35 and 18.4 μM, respectively); inhibits ACE (IC50 = 13.22 μM); reduces both systolic and diastolic blood pressure in spontaneously hypertensive rats at 5 mg/kg; induces apoptosis and halts the cell cycle at the S phase in A549 lung cancer cells at 5, 10, and 20 μM; reduces tumor growth in an A549 mouse xenograft model at 10 and 20 mg/kg
Cayman Chemical Cholyl-1 3-dIamInopropn 10mg
A polyamine bile amidate; has been used as a standard for the detection of endogenous bile acid amidates in mammalian intestinal and fecal samples
Cayman Chemical IncyclInIde 10mg
An inhibitor of MMP-13, MMP-1, and MMP-8 (IC50s = 0.3, 34, and 48 UG/ml, respectively); inhibits chick osteoclast digestion of isolated bovine bone at 5 UG/ml and IL-1-induced glycosaminoglycan release from porcine articular cartilage explants at 10 UG/ml; induces cytotoxicity of HeLa and SiHa human cervical cancer cells
Cayman Chemical RheIn-8-glucosIde 10mg
An anthraquinone glycoside; increases the rate of sennoside A metabolism by mouse intestinal bacteria in vitro at 0.03-1 mM; increases the purgative activity of sennoside A in mice in a dose-dependent manner; inhibits PTP1B (IC50 = 11.5 μM); metabolized to rhein by intestinal bacteria
Cayman Chemical 1 2 3TrI10 ZHeptadecenoyl 10mg
An internal standard for the quantification of 1,2,3-tri-10(Z)-heptadecenoyl glycerol by GC- or LC-MS
Cayman Chemical Scutlaa bacalns Nowogn 10mg
A polyhydroxy flavone with diverse biological activities; scavenges ABTS and DPPH radicals in cell-free assays (IC50s = 1.24 and 35.61 μg/ml, respectively); inhibits EV71-induced cytopathic effects in infected Vero cells (IC50 = 31.83 μg/ml); reduces the viability of MDA-MB-231, BT-549, HCC70, and HCC1806 TNBC cells (IC50s = 32.24, 56.2, 39.05, and 37.3 μM, respectively) but not the non-tumorigenic cell lines MCF-10A and AG11132 (IC50s = >100 μM for both); induces cell cycle arrest at the G1 and G2/M phases and increases apoptosis in MDA-MB-231 cells
Cayman Chemical DIhydrosnguInarIn 10mg
A metabolite of sanguinarine with diverse biological activities; inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells at 10, 20, and 30 µM; reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells
Cayman Chemical dmodum styracfolum Vcn2 10mg
A flavonoid glycoside with diverse biological activities; inhibits thrombin-induced aggregation of isolated mouse platelets from 2-30 µM; increases tail bleeding time in mice at 35.7 UG/animal; reduces tumor growth in a PC3 prostate cancer mouse xenograft model at 1 mg/kg; decreases trabecular separation, as well as increases trabecular thickness and area, in an ovariectomized rat model of osteoporosis; decreases ulceration and increases colon weight and length in a mouse model of DSS-induced colitis at 50 mg/kg
Cayman Chemical VIcrIvIrocmaleate 10mg
A CCR5 antagonist (Ki = 2.5 nM); selectively inhibits CCR5 over M1 and M2 muscarinic acetylcholine receptors (Kis = >10,000 nM for both) and hERG potassium channels (IC50 = 5.8 µM); decreases CCL3-induced chemotaxis of Ba/F3 cells expressing recombinant human CCR5 (IC50 = 0.91 nM); inhibits the replication of 30 R5-tropic HIV-1 clinical isolates in PMBCs (EC50s = 0.04-1.4 nM) and reduces viral entry of seven drug-resistant strains of HIV-1 in U87 cells expressing CD4 and CCR5 (EC50s = 8.7-32.9 nM)
Cayman Chemical PlntamajosIde 10mg
A phenylethanoid with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 11.8 µM); inhibits 5- and 15-LO (IC50s = 0.375 and 96 µM, respectively); decreases viability of TE-1 ESCC cells at 20-320 UG/ml, as well as inhibits LPS-induced EMT in Eca-109 and TE-1 cells and decreases phosphorylated NF-κB levels in TE-1 cells; inhibits arachidonic acid-induced mouse EAr edema at 3 mg/ear
Cayman Chemical GemcItabIn ElaIdate 10mg
A prodrug form of gemcitabine; inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 µM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells or gemcitabine-resistant AG6000 cells; reduces tumor growth in EKVX non-small cell lung cancer and MHMX sarcoma mouse xenograft models at 40 mg/kg every three days
Cayman Chemical AmIfostIn thIolhydrochLRI 10mg
A radioprotective agent and an active metabolite of amifostine; scavenges ABTS radicals in a cell-free assay; prevents γ-radiation-induced single- and double-stranded DNA breaks, as well as inhibits γ-radiation induced mutations at the HGPRT locus in V79-B310H lung fibroblast cells at 4 mM; reduces cis-DDP-induced mutations at the HGPRT locus in V79-B310H cells; increases survival, reduces the loss of bone marrow progenitor cells, and inhibits decreases in intestinal collagen thickness and crypt and Paneth cell density in mice exposed to total body γ-irradiation at 500 mg/kg prior to irradiation
Cayman Chemical SaxaglIptInhydrochlorIde 10mg
A potent DPP-4 inhibitor (Ki = 0.6 nM); inhibits DPP-4 ex vivo (ED50 = 0.12 μmol/kg) in plasma from normal fasted rats; reduces plasma glucose levels in Zuckerfa/fa diabetic rats in a dose-dependent manner when administered orally in doses ranging from 0.3-3 mg/kg; increases plasma insulin levels and improves glucose clearance in ob/ob mice; induces systolic and diastolic dysfunction, reduces contractile force, and exacerbates ischemia-reperfusion injury-induced cardiac dysfunction in isolated guinea pig hearts