Custom Peptides
Cayman Chemical Periplogenin 10MG
A cardenolide and an active metabolite of periplocin with diverse biological activities; reduces the activity of porcine Na+/K+ ATPase at 0.3 or 0.6 µM; induces apoptosis in U937 and PC3 prostate cancer cells, as well as inhibits the proliferation of these cells (EC50s = 1.41 and 1.2 µM, respectively) at 0.1 or 0.2 µM; increases ROS production and induces necroptosis in HaCaT keratinocytes at 2 UG/ml; reduces EAr thickness in a mouse model of TPA-induced psoriasis
Cayman Chemical Prenylamn 10mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
Cayman Chemical 3 3-2-Chlorophenylmethyle 10mg
An ENPP1 inhibitor (Ki = 50 µM); inhibits urease (IC50 = 84.53 µM for the Jack bean enzyme)
Cayman Chemical SophocarpIn 10mg
An alkaloid with diverse biological activities; cytotoxic to various cancer cell lines (IC50s = 1.64-12.86 mM); nematocidal against B. xylophilus in vitro; reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury at 30 mg/kg; decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of NASH; reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice at 15 and 30 mg/kg
Cayman Chemical OxcarbazepIn 10mg
A prodrug form of 10,11-dihydro-10-hydroxy carbamazepine; inhibits high-frequency repetitive firing of rat spinal cord neurons at 1 µM; protects against electroshock-induced tonic hindlimb extension (ED50 = 10-20 mg/kg), as well as PTZ- or picrotoxin-induced seizures in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively)
Cayman Chemical 4AmInomethyl4 5 8trImeth 10mg
A bifunctional photoreactive agent for crosslinking nucleic acids; intercalates into double-stranded regions in DNA or RNA and, upon UV irradiation, forms covalent adducts with pyrimidine bases; used to study different types of RNA from diverse organisms, including viruses
Cayman Chemical -4-hydroxy Proprnololhy 10mg
An active metabolite of (±)-propranolol; decreases isoproterenol-induced tachycardia and vasodepression in cats (EC50 = 54 UG/kg); increases heart rate in catecholamine-depleted rats at 10 and 80 UG/kg; decreases heart rate, myocardial contractility, and cardiac output in dogs in a dose-dependent manner; reduces superoxide-induced lipid peroxidation in isolated rat hepatic microsomes (IC50 = 1.1 µM) and prevents superoxide-induced depletion of GSH levels in BAEC cells (EC50 = 1.2 µM)
Cayman Chemical DB2313hydrochlorIde 10mg
A PU.1 inhibitor (IC50 = 14 nM); long-term exposure reduces KSL-HSPC colony formation at 300 nM; decreases ovalbumin-induced reprogramming of isolated mouse neutrophils into antigen-presenting cells at 700 nM; decreases tumor growth, weight, and volume in a U87MG glioblastoma multiforme mouse xenograft model at 10 mg/kg per day
Cayman Chemical BIlIverdInhydrochlorIde 10mg
A green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and further reduced to bilirubin by biliverdin reductase; possesses anti-mutagenic and antioxidant properties, scavenging free radicals
Cayman Chemical LevocabastInhydrochlorIde 10mg
A histamine H1 receptor antagonist (Ki = 62.5 nM); selective for histamine H1 over H2 and H3 receptors (Kis = 23.5 and 1.94 µM, respectively); binds to the rat neurotensin-2 receptor (IC50 = 10 nM); reduces the severity of ovalbumin-induced conjunctivitis in ovalbumin-sensitized rats when applied ocularly to ovalbumin-sensitized rats
Cayman Chemical 4 2 2 3TrImthylcycloPNtyl 10mg
An orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43; prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells (IC50s = 7.9 and 2.4 µM, respectively)
Cayman Chemical BGC 20-1531hydrochlorIde 10mg
A potent and selective EP4 receptor antagonist (Kis = 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively); selective for EP4, exhibiting 2-induced cAMP accumulation in HEK293 EBNA cells that stably express human EP4 receptors; reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings; prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance in dogs (ID50 = 5 mg/kg)
Cayman Chemical T2AAhydrochlorIde 10mg
An inhibitor of PCNA; inhibits protein-protein interactions between PCNA and a PIP-box-containing peptide (IC50 = 1 μM) as well as full-length p21; reduces cellular colocalization of PCNA and DNA polymerase δ; inhibits DNA replication and cell growth in U2OS and HeLa cells; induces cell cycle arrest at the S phase at 20 μM; increases cisplatin-induced DNA double strand break formation in a neutral comet assay and inhibition of clonogenic survival in HeLa and U2OS cells
Cayman Chemical IsochlortetracyclIn 10mg
An inactive alkaline degradation product of chlortetracycline; appears to be a product of in vivo chlortetracycline metabolism