Custom Peptides
Cayman Chemical Nethyl Perfluoroctnsulfon 10mg
N-ethyl Perfluorooctanesulfonamide (N-ethyl FOSA) is a perfluoroalkyl substance (PFAS) and an insecticide.{49815,49816} It decreases the coupling efficiency, increases the rate of state four respiration, and uncouples mitochondrial oxidative phosphorylation in rat liver mitochondria when used at a concentration of 6.25 µM.{49817} N-ethyl FOSA reduces foraging activity of leaf-cutting ants (A. lundi) and reduces colony survival when applied in colonies as a 0.3% bait.{49816} It has been found in human blood and Arctic air samples.{49815,49818}
Cayman Chemical Cornus ofcnals Cornusde 10mg
A bisiridoid glycoside with diverse biological activities; induces osteogenic differentiation of isolated human BMSCs at 10, 30, and 60 µM; reduces demyelination, focal inflammation, and Th17 cell spinal cord infiltration, as well as improves neurological deficits in a rat model of EAE at 150 mg/kg; decreases mortality, vascular instability, and pulmonary leukocyte infiltration in a mouse model of cecal ligation and puncture-induced sepsis at 0.4 and 0.8 mg/kg; reduces polydipsia and polyphagia, lowers fasting blood glucose levels, prevents testicular cell apoptosis, and decreases the abundance of Weissella, Clostridium, Anaerotruncus, and Bilophila in the gut microbiome in KK/Ay diabetic mice
Cayman Chemical BuccalIn AtrIfluoroacetAT 10mg
A neuropeptide; reduces current-induced muscle contraction size but not muscle relaxation rate in isolated and washed A. californica ARC muscle fibers at 10 nM; decreases the amplitude of inhibitory post-synaptic currents (IPSCs) in isolated and perfused voltage-clamped A. californica buccal ganglia at 10 µM
Cayman Chemical DIhydromyrIstIcIn 10mg
A derivative of myristicin; induces GST activity in the liver and small intestinal mucosa but not the forestomach, lungs, large intestinal mucosa, or bladder in mice at 20 mg/animal
Cayman Chemical Ala17-MCHtrIfluoroacetate 10mg
An MCH-derived peptide and MCH receptor agonist; binds to MCH1 and MCH2 receptors in CHO cells expressing the human receptors (IC50s = 0.15 and 3.5 nM, respectively); induces calcium mobilization in HEK293 cells expressing the human receptors (EC50s = 17 and 54 nM, respectively)
Cayman Chemical ClenbuterolhydrochlorIde 10mg
A β2-AR agonist; induces relaxation of equine tracheal muscle strips (EC50 = 2.1 nM); increases the number of autophagosomes and autophagic flux in HepG2 cells at 300 nM; increases blood flow to adipose tissue and induces weight gain in rats at 2 mg/kg; induces relaxation of bovine uterus; inhibits infection of MDCK cells by an H1N1 influenza isolate in vitro (EC50 = 9.4 µM)
Cayman Chemical DovItInIblactate 10mg
A multi-kinase inhibitor; inhibits FLT3, CSF1R, c-Kit, FGFR1, FGFR3, VEGFR1, -2, and -3, PDFGRα, and PDGFRβ (IC50s = 1, 36, 2, 8, 9, 10, 13, 8, 27, and 210 nM, respectively); inhibits the proliferation of human multiple myeloma cell lines expressing mutant, but not wild-type, FGFR3 (IC50s = 90-550 and >2,500 nM, respectively); decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM; inhibits bFGF-induced angiogenesis in a Matrigel™ plug assay in mice at 3-300 mg/kg for 8 days; reduces tumor growth in KM12L4A, DU145, and MV4-11 mouse xenograft models (ED50s = 17, 23, and 3 mg/kg per day, respectively)
Cayman Chemical 2AmIno3methylImIdazo4 5f 10mg
A food-derived carcinogen; metabolized by CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts; induces formation of single-base substitutions and exon deletions and increases cell death in vitro; increases incidence of squamous cell hyperplasias in the stomach of p53 knockout mice; increases hepatocellular lesions in female mice regardless of p53 status
Cayman Chemical Q1-SM-102IodIde 10mg
A cationic quaternary ammonium lipid derivative of SM-102; LNPs containing Q1-SM-102 and SM-102 as a CLP and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice
Cayman Chemical BrasInolIde 10mg
A biologically active brassinosteroid that has important roles in regulating plant growth and development
Cayman Chemical KIspeptIn-10zebrafIshtr 10mg
A neuropeptide; increases levels of the mRNA encoding Lh receptor, as well as Pra and Prb, in isolated zebrafish ovarian follicles at 10 ng/ml; increases luteinizing hormone serum levels in female, but not male, goldfish at 0.1 and 1 UG/g
Cayman Chemical 3-IsomngostIn 10mg
A xanthone with diverse biological activities; an inhibitor of MTH1 (IC50 = 52 nM); inhibits aldose reductase (IC50 = 3.48 µM), AChE (IC50 = 2.36 UG/ml), and BChE (IC50 = 5.32 UG/ml); inhibits the growth of P. falciparum strains D6 and W2 in isolated and infected red blood cells (IC50s = 3.23 and 2.52 UG/ml, respectively); inhibits cyclin D2/Cdk4 and cyclin E1/Cdk2 (EC50s = 15.6 and 34.92 µM, respectively) and reduces viability of HCC1937 and HCT116 cells (IC50s = 59.9 and 47.4 µM, respectively)
Cayman Chemical 1 2DIoleoyl3trImethylamon 10mg
A cationic lipid; has been used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells; has been used in the composition of small unilamellar liposomes formulated as gene delivery vectors for gene therapy
Cayman Chemical 2DeoxycytIdIn 5dIphospha 10mg
A nucleotide diphosphate for various biochemical research applications including studies of DNA synthesis; substrate for nucleoside diphosphate kinases