Custom Peptides
Cayman Chemical GBR 12783hydrochlorIde 10mg
A dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes); selective for inhibition of dopamine uptake over norepinephrine or 5-HT uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively); improves learning and memory in the passive avoidance test in rats at 10 mg/kg, i.p., an effect that can be blocked by scopolamine; increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice; inhibits haloperidol-induced catalepsy in rats at 10 mg/kg
Cayman Chemical Trbulus trstrs L Gtogn 10mg
A sapogenin with enzyme inhibitory and hormone-releasing activities; an inhibitor of UGT1A4 (IC50 = 0.69 µM); stimulates the release of growth hormone in primary rat pituitary cells at 20 UG/ml
Cayman Chemical DexloxIglumIde 10mg
A CCK1 receptor antagonist; selectively binds to the CCK1 receptor over CCK2 in CHO cells expressing the rat receptors (Kis = 0.0234 and 5.88 µM, respectively); inhibits guinea pig CCK-8S-induced gall bladder contractions at 20 µmol/kg; reduces CCK-8-induced gastric emptying in rats (ID50 = 1.14 mg/kg)
Cayman Chemical nastrozole 10mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical 5-TetrahydrocortIsol 10mg
An endogenous metabolite of cortisol and intermediate in the biosynthesis of β-cortol
Cayman Chemical AlytSIntrIfluoROCTAte sa 10mg
A neuropeptide with diverse biological activities; induces hypertension with tachyphylaxis and increases blood glucose levels in dogs; reduces gastric acid secretion in rats; induces anorexigenic effects in neonatal chicks
Cayman Chemical 5-trns ProstaglndIn D2 10mg
The trans isomer of PGD2 occurs as an impurity between 2-5% in most commercial preparations of the bulk drug product. This compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, the biological activity of 5-trans PGD2 is likely to be similar to that of the cis isomer. However, there are no specific published reports on the biological activity of 5-trans PGD2.
Cayman Chemical Cholyl-1 3-dIamInopropn 10mg
A polyamine bile amidate; has been used as a standard for the detection of endogenous bile acid amidates in mammalian intestinal and fecal samples
Cayman Chemical 1-MSHhumnmouseratbo 10mg
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo at 0.01 nmol/animal
Cayman Chemical DOTA-NOCacetate 10mg
A synthetic peptide; has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo
Cayman Chemical DIltIazem-d3hydrochlorIde 10mg
An internal standard for the quantification of diltiazem by GC- or LC-MS
Cayman Chemical ANTIBODYR-AS-1 10mg
A positive allosteric modulator of EAAT2 (EC50 = 11 nM in a glutamate uptake assay); selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes; increases spontaneous locomotor activity in mice at 60 and 90 mg/kg; has anticonvulsant activity in mouse models of seizures induced by MES, PTZ, or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively)
Cayman Chemical AconItum SongorIn 10mg
A diterpene alkaloid with diverse biological activities; an antagonist of the GABAA receptor (IC50 = 7.06 µM in rat brain membranes); reduces the viability and migration of, and induces apoptosis in, SKOV3 and A2780 epithelial ovarian cancer cells at 20-80 µM; reduces tumor growth in a SKOV3 mouse xenograft model at 0.25 and 2.5 mg/kg; prevents and inhibits paw edema in a mouse model of carrageenan-induced inflammation at 0.025 mg/kg; has antinociceptive activity in the EArly phase of the formalin test in mice at 46.4 mg/kg
Cayman Chemical RIzatrIptnbenzoate salt 10mg
A 5-HT1B and 5-HT1D receptor agonist (Kis = 4.3 and 10.1 nM, respectively); selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors (Ki = 140 nM); induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 90 nM); reduces pain behaviors and photophobia in a Cacna1a mutant transgenic mouse model of migraine at 50 and 75 mg/kg
Cayman Chemical Mastoparn XtrIfluoroACTAt 10mg
An antimicrobial peptide; active against several Gram-positive and Gram-negative bacteria (MICs = 3-64 and 4-256 UG/ml, respectively) and induces permeabilization of E. coli cytoplasmic membranes by 86% at 6.4 UG/ml; induces GDP/GTP exchange by Gi and binds to calmodulin (Kd = ~0.9 nM) in cell-free assays; induces necrosis in T98G cells at 20 µM; induces degranulation of isolated rat peritoneal mast cells at 128 UG/ml; induces hemolysis of isolated sheep, chicken, and human erythrocytes; increases survival, decreases disease severity, and prevents damage to jejunal villi and crypts in a mouse model of enterohemorrhagic E. coli infection at 20 mg/kg