Custom Peptides
Cayman Chemical dmodum styracfolum Vcn2 10mg
A flavonoid glycoside with diverse biological activities; inhibits thrombin-induced aggregation of isolated mouse platelets from 2-30 µM; increases tail bleeding time in mice at 35.7 UG/animal; reduces tumor growth in a PC3 prostate cancer mouse xenograft model at 1 mg/kg; decreases trabecular separation, as well as increases trabecular thickness and area, in an ovariectomized rat model of osteoporosis; decreases ulceration and increases colon weight and length in a mouse model of DSS-induced colitis at 50 mg/kg
Cayman Chemical PItavastatIncalcIum salt 10mg
An HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme); inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively); reduces plasma levels of triglycerides and total cholesterol in dogs; increases survival in Dahl salt-sensitive rats fed a high-salt diet at 0.3 mg/kg
Cayman Chemical Latnoprost ethyl amIde 10mg
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 UG/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
Cayman Chemical 15keto17phenl trInor Pros 10mg
A keto derivative of an F-series prostaglandin and a metabolite of 17-phenyl trinor PGF2α ethyl amide
Cayman Chemical AzasetronhydrochlorIde 10mg
An orally bioavailable 5-HT3 antagonist (Ki = 2.9 nM); selective for 5-HT3 over 5-HT1A and 5-HT2 (IC50 = >10 μM for both), as well as D1, D2, α1-, and α2-adrenergic receptors (IC50s = >10 μM); binds to H1 receptors (IC50 = 4.4 μM); inhibits 5-HT-induced contractions in isolated guinea pig ileum (pA2 = 7.04) and isolated rabbit heart (pA2 = 10.06); inhibits cisplatin-induced emesis in dogs and doxorubicin/cyclophosphamide-induced emesis in ferrets at 1 mg/kg
Cayman Chemical OxytocInacetate 10mg
A nonapeptide hormone primarily synthesized in the hypothalamus with roles in uterine contraction and lactation, social memory and attachment, sexual and maternal behavior, aggression, learning, anxiety, feeding, and pain perception
Cayman Chemical ArphamenIn BhemIsulfate 10mg
An aminopeptidase B inhibitor that is commonly used to characterize novel proteases
Cayman Chemical LY2835219methnsulfonate 10mg
An orally-bioavailable dual inhibitor of CDK4 and CDK6 (IC50s = 2 and 10 nM, respectively); has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds
Cayman Chemical StevIosIdehydrate 10mg
A natural non-caloric sweetener; increases glucose-stimulated insulin secretion in isolated mouse pancreatic islets at 1 µM; reduces LPS-stimulated increases in TNF-α and IL-1β production in THP-1 cells, but also induces TNF-α and IL-1β production in unstimulated THP-1 cells at 1 mM; decreases systolic blood pressure in GK type 2 diabetic rats at 0.03 g/kg; reduces TPA-induced EAr edema in mice (ID50 = 291.6 UG/ear)
Cayman Chemical nastrozole 10mg
An aromatase/CYP19A1 inhibitor (IC50 = 15 nM for human placental aromatase/CYP19A1); selective for aromatase/CYP19A1 over CYP1A2, CYP2A6, CYP2C9, CYP2D6, and CYP3A (IC50s = 27-650 μM); blocks ovulation in mature female rats and androstenedione-stimulated uterine development in pubertal female rats at 0.1 mg/kg; inhibits peripheral aromatase/CYP19A1 and reduces plasma estradiol concentrations in male pigtailed monkeys at ≥0.1 mg/kg; reduces tumor incidence and the number of tumors well as increases latency to tumor appearance in a rat model of premenopausal mammary tumorigenesis at 0.5 mg/kg
Cayman Chemical NortrIptylInhydrochlorIde 10mg
A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM)
Cayman Chemical Nacetyl3 4MethylendIoxyme 10mg
An acetylated analog of methylone, the MDMA-type designer drug that has been detected in products marketed as bath salts, plant food, and tablets; intended for forensic and research purposes
Cayman Chemical -2-Methyl ArachIdonyl-2- 10mg
An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor (Ki = 5.7 nM in rat brain); in vivo activity is enhanced much less than the binding affinity, because the analog is rapidly hydrolyzed by AEA; the addition of an α-methyl group at the C-2 position of arachidonic acid confers enhanced metabolic stability; can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot
Cayman Chemical MethylpIperIdIno pyrazole 10mg
A highly selective ERα receptor antagonist (Ki = 5.6 nM; IC50 = 80 nM)