Custom Peptides
Cayman Chemical 2-O-RhamnosylIcarIsIde II 10mg
A flavonoid glycoside scavenges DPPH radicals in a cell-free assay (IC50 142 UM) increases proliferation of UMR-106 osteoblasts by 30 4 and 41 6 at 0 1 and 10 UM respectively inhibits TPA-induced ear edema in mice (ED50 192 nmol/ear)
Cayman Chemical PhenformInd5hydrochLRIde 10mg
An oxysterol and a negative allosteric modulator of GABAA receptors reduces GABA-induced currents in HEK cells expressing a1B1Y2 or a4B3Y2 subunit-containing GABAA receptors (IC50s 1 5 and 1 UM respectively) reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors C-LTMRs and cold thermosensors in isolated mouse DRG neurons increases latency to nocifensive behaviors in the hot plate test in mice at 2 10 and 50 mg/kg
Cayman Chemical TrIgonlIn-d3chlorIde 10mg
A pentacyclic triterpenoid induces cell cycle arrest at the G0/G1 phase and inhibits proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner prevents hydrogen peroxide-induced DNA damage in the same cells induces relaxation of phenylephrine- or potassium chloride-precontracted aortic rings isolated from spontaneously hypertensive rats at 100 UM inhibits ovalbumin-induced BALF eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma
Cayman Chemical 2-HydroxyadIpIc AcId 10mg
A macrolide antibiotic active against S aureus E coli and P multocida (MICs 2 128 and 128 Ug/ml respectively) reduces LPS-induced production of pro-inflammatory cytokines prostaglandin E2 (PGE2 Item No 14010) and nitric oxide in RAW 264 7 cells at 5 and 10 Ug/ml reduces the severity of lung lesions in pigs infected with M hyopneumoniae and P multocida at 10 mg/kg per day in the drinking water
Cayman Chemical RhamnocItrIn 10mg
Immunogen Peptide from the C-terminal region of human cytokeratin 10 Host Rabbit Species Reactivity ( ) Human Cross Reactivity ( ) Cytokeratin 10 Applications IHC WB
Cayman Chemical Fulvestrnt 9-sulfon 10mg
A pan HIF-PH inhibitor (Kis 16 61 and 101 nM for HIF-PH1 -2 and -3 respectively) increases EPO levels in Hep3B cells (EC50 4 7 UM) increases plasma EPO levels in control rats as well as plasma EPO and hemoglobin levels in 5/6-nephrectomized rats at 3 mg/kg decreases renal fatty acid and amino acid metabolism and increases renal glucose metabolism in streptozotocin-induced rat and alloxan-induced mouse models of diabetic nephropathy
Cayman Chemical 21-DeoxycortIson 10mg
A PROTAC that drives BRD4 degradation selectively degrades BRD4 over BRD3 and BRD2 in HeLa cells at 300 nM
Cayman Chemical BlarcamesIn 10mg
Immunogen Peptide corresponding to H3K9Cr Host Rabbit Species Reactivity ( ) Vertebrates Cross Reactivity ( ) H3K9Cr H3K9Bu H3K9Pr (weakly) (-) Unmodified histone H3 H3K9Ac H3K9Bhb Applications Dot blot multiplex-based assay WB
Cayman Chemical RebaudIosIde M 10mg
A GlcCer synthase inhibitor reduces Gb3 and lyso-Gb3 accumulation in a variety of tissues in the Gla-/- mouse model of Fabry disease reduces the latency to paw withdrawal in the hot plate test in the same model reduces gliosis delays the onset of ataxia and increases lifespan in the transgenic 4LC mouse model of neuronopathic Gaucher disease at 0 03 w/w in the diet
Cayman Chemical MOG35-55mouseratrI 10mg
A K-opioid receptor antagonist (Ki 0 722 nM) selective for the KOR over - and -opioid receptors (Kis 25 8 and 153 nM respectively) reduces immobility time in the forced swim test and reduces salvinorin A-induced decreases in grooming time in the splash test in mice at 0 1 mg/kg i p
Cayman Chemical HIstatIn 5trIfluoroacetAT 10mg
A penem antibiotic active against a panel of 12 Gram-positive (MIC50s 0 008-1 mg/L) and 15 Gram-negative (MIC50s 0 06-16 mg/L) bacteria reduces the number of lung CFUs in a mouse model of H influenzae-induced respiratory tract infection
Cayman Chemical GambogenIc AcId 10mg
A perylenequinone fungal metabolite induces the production of singlet oxygen and apoptosis in R366 4 and HCe-8693 cells from 1-100 UM
Cayman Chemical Desmethyl CarvedIlol 10mg
A polyphenol with diverse biological activities scavenges DPPH radicals inhibits XO (IC50 7 36 UM) decreases protein levels of tyrosinase and MITF in B16/F1 murine melanocytes inhibits melanogenesis in the same cells and decreases tyrosinase activity in cell lysates at 25 UM increases biliary flow in rats
Cayman Chemical BetahIstInd3hydrochLRIde 10mg
A protein tyrosine phosphatase inhibitor inhibits autocrine growth of A549 lung A498 kidney and DU145 prostate cancer cells from 1-20 UM protects mice from radiation-induced hematopoietic and gastrointestinal syndromes at 20 mg/kg reduces postprandial glucose levels and increases glucose tolerance in a rat model of streptozotocin-induced diabetes decreases total and cortical infarct size in a rat model of transient MCAO-induced ischemia-reperfusion injury