Custom Peptides
Cayman Chemical Annaosanchun 10mg
A synthetic sterol and neuroprotective agent; increases the viability of, and the levels of ATP and the mitochondrial membrane potential in, hypoxia-exposed and reoxygenated primary rat cortical neurons at 0.1, 0.3, and 1 µM; prevents glutamate-induced increases in intracellular acidification, lactate levels, and glycolysis rate, as well as inhibits glutamate-induced apoptosis, in primary rat cerebral granule neurons at 10 µM; reduces neurological and neuromuscular deficits and infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury at 0.5, 2, or 10 mg/kg
Cayman Chemical ThIoargInInhydrobromIde 10mg
A colorimetric arginase substrate; hydrolyzed to 2-amino-5-mercaptovaleric acid, which reacts with DTNB to form 2-nitro-5-thiobenzoate and can be quantified by colorimetric detection at 412 nm as a measure of arginase activity
Cayman Chemical RetatrutIdesodIum salt 10mg
A GCGR, GLP-1R, and GIP receptor agonist; induces cAMP accumulation in HEK293 cells expressing the human GCGR, GLP-1R, or GIP receptor (EC50s = 5.79, 0.775, and 0.0643 nM, respectively); decreases plasma glucose levels in an intraperitoneal glucose tolerance test in mice from 0.1-30 nmol/kg; decreases body weight, calorie intake, fat mass, and lean mass in a mouse model of diet-induced obesity; acute administration delays gastric emptying and chronic administration for 10 days decreases food intake and body weight in mice
Cayman Chemical MyomodulIn AAplysIaLymnae 10mg
A gastropod neuropeptide; potentiates motor neuron-elicited contractions of the A. californica buccal mass ARC; increases the relaxation rate of electrically evoked muscle contractions in L. stagnalis penis retractor muscle
Cayman Chemical ML-133hydrochlorIde 10mg
A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal
Cayman Chemical CapsIconIate 10mg
A coniferyl ester that acts as a partial agonist of TRPV1 (EC50 = 3.2 µM), eliciting only 20% of the maximum response induced by capsaicin
Cayman Chemical MocetInostat 10mg
An orally available HDAC inhibitor that selectively targets HDAC1 and 2 (IC50s = 0.15 and 0.29 µM, respectively), less potently inhibits HDAC3 and 11 (IC50s = 1.66 and 0.59 µM, respectively); induces hyperacetylation of histones, causes cell cycle blockade, and induces apoptosis in cancer cells in vitro
Cayman Chemical HIrudIn54-65non-sulfated 10mg
A desulfated peptide fragment of hirudin; inhibits isolated bovine thrombin-induced fibrin clot formation (IC50 = 3.7 µM)
Cayman Chemical CapromorelIntartrate 10mg
A GH secretagogue and an agonist of GHS-R1a; stimulates GH release from primary rat pituitary cells EC50 = 3 nM); stimulates intracellular calcium mobilization in primary rat pituitary cells at 0.3, 3, and 30 nM; increases rat serum GH levels (ED50 = 0.04 mg/kg, i.v.); decreases dog serum IGF-1 levels at 1 mg/kg, p.o.; increases rat body weight by 43.6% without affecting whole-body percentages of fat, lean mass, or bone content at 3.9 mg/kg, once per day for 28 days; decreases infarct size in a rabbit model of ischemia-reperfusion injury induced by left coronary artery occlusion at 25 mg/kg
Cayman Chemical 6-deoxy-L-Talose 10mg
A microbial monosaccharide; has been found in the cell wall of bacteria such as S. bovis and in the O-specific polysaccharide of LPS in species including E. coli and P. maltophilia; a component of the surface glycopeptidolipids of M. avium
Cayman Chemical ttramthylrhodamIn IsoTHOc 10mg
An amine-reactive derivative of rhodamine that is used as a fluorescent label for antibodies and other probes (ex/em max = 552/575 nm)
Cayman Chemical EIcosapentaenoyl SRotonIn 10mg
A hybrid molecule patterned after arachidonoyl serotonin; the biological effects of eicosapentaenoyl serotonin are unknown
Cayman Chemical Tnactum patnum Aglabn 10mg
A sesquiterpene γ-lactone; inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively); reduces tumor growth in an SCC-4 mouse xenograft model at 40 UG/g; reduces protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages at 50 nM; a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at 50 nM; decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet at 2.5 ng/g
Cayman Chemical S-PhenylsulfonylcysteIn 10mg
A reagent for blocking thiol (-SH) groups on proteins and peptides, as a first step of the thiosulfonate switch technique
Cayman Chemical DorIpenmhydrate 10mg
A broad-spectrum antibiotic; is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection at 100 mg/kg per day