Custom Peptides
Cayman Chemical 5 N NhexamethylenAmIlorI 10mg
An amiloride derivative with diverse biological activities; an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM); inhibits the cation-selective ion channel formed by Vpu at 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu at 10 µM; blocks the cation-selective ion channels formed by p7; induces necrosis in and reduces the viability of various breast cancer cells at 40 µM; protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls
Cayman Chemical 13Z 16ZDocosadIenoIc AcId 10mg
A natural ω-6 PUFA; an agonist of FFAR4 (GPR120) that strongly inhibits the secretion of ghrelin by isolated mouse gastric cells
Cayman Chemical PalmItoylLcarnItInchLRI 10mg
A long-chain acylcarnitine; delivers palmitate into the mitochondria for fatty acid oxidation and energy production; inhibits lecithin:cholesterol acyltransferase activity in isolated rat plasma at 500 µM; serum and hepatic levels are increased in mice during cold exposure; protects against age-induced cold sensitivity in mice
Cayman Chemical Sartrypyron B 10mg
A fungal metabolite; inhibits the growth of MCF-7, H460, and A375 cancer cells (GI50s = 17.8, 20.5, and 25 µM, respectively)
Cayman Chemical Acontum carmchal Dlsoln 10mg
A diterpene alkaloid with diverse biological activities; inhibits binding of α-bungarotoxin to rat neuronal α7 nAChRs (IC50 = 19 µM); repellent against adult red flour beetles in a filter paper assay at 3 mg/ml; lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension at 75 mg/kg
Cayman Chemical -JQ1free acId 10mg
An inhibitor of BET family proteins; binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively
Cayman Chemical CardIolIpIn18 018 018 01 10mg
A phospholipid containing the long-chain saturated fatty acid stearic acid
Cayman Chemical JWH398 7CLORNaphthyl Isom 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical Dydrogesteron 10mg
A synthetic progestin; has no estrogenic, androgenic, glucocorticoid, or anabolic effects; an agonist of progesterone receptors (EC50 = 12.3 nM); an antagonist of androgen, mineralocorticoid, and glucocorticoid receptors (IC50s = 28.6, 82.7, and 363 nM, respectively); protects against sound stress-induced abortion in mice at 1.25 mg per animal on day five of pregnancy
Cayman Chemical HomoplntagInIn 10mg
A flavonoid glycoside; scavenges DPPH radicals (IC50 = 0.35 UG/ml); reverses hydrogen peroxide-induced decreases in GSH levels and GPX and SOD activity in HL-7702 cells from 1-100 UG/ml; prevents palmitic acid-induced increases in protein levels of TLR4, MyD88, caspase-1, and IL-1β levels in HUVECs at 1 and 10 µM; decreases serum ALT, AST, TNF-α and IL-1 levels, as well as reduces liver inflammatory cell infiltration and hepatocyte necrosis in a mouse model of immunological liver injury induced by BCG vaccine and LPS
Cayman Chemical 10PnxtrIfluoroacetAT salt 10mg
A peptide inhibitor of PANX1; inhibits purinergic P2X7 receptor activation-induced dye uptake, constitutive dye uptake, and hemichannel currents, as well as ATP-induced caspase activation and IL-1β release in HEK293 cells at 200 µM; inhibits pannexin channel currents and connexin 46 channel currents in Xenopus oocytes expressing the human channels
Cayman Chemical BenzoylCoenzyme AsodIM sa 10mg
An intermediate in the microbial metabolism of aromatic compounds; can be produced via anaerobic metabolism of benzoate, toluene, and phenylalanine, among others, in the environment as well as the gut microbiome; can be produced from benzoate by a benzoate-CoA ligase under both aerobic and anaerobic conditions in proteobacteria; is a precursor in the biosynthesis of enterocin in Salinospora; has been used as a substrate to measure the enzyme kinetics of human recombinant GLYAT