Drug Discovery Research Screening Libraries
Apexbio Technology LLC DiscoveryProbe™ Metabolism-related Compound Library Plus, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
DiscoveryProbe™ Metabolism-related Compound Library Plus is a unique collection of 1205 metabolism-related compounds for metabolism research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
AdipoGen T0901317
Chemical. CAS 293754-55-9. Formula C17H12F9NO3S. MW 481.3. T0901317 is a potent, cell permeable and selective agonist of LXRalpha and LXRbeta EC50 of 50nM, Kd values are 7 and 22 nM for LXR-alpha and LXR-beta, respectively, results in LXR-dependent up-regulation of ABC1 gene expression. The Liver X Receptors LXRalpha and LXRbeta are nuclear hormone receptors whose native ligands are oxysterols. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol and regulation of HDL metabolism. T0901317 activates farnesoid X receptor FXR EC50 ~5µM, less potent then LXR, but activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. It also is a high-affinity ligand for the xenobiotic receptor pregnane X receptor PXR.
AdipoGen D-Fructose 1 6-diphosphate 3Na
Chemical. CAS 38099-82-0. Formula C6H11Na3O12P2 . xH2O. MW 406.06 anhydrous basis. Synthetic. D-Fructose-1,6-bisphosphate FBP, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolases and fructose-1, 6-bisphosphatases. FBP is studied as a neuroprotective agent in brain injury.
AdipoGen C7-L-HSL
Chemical. CAS 177158-20-2. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence, infection prevention and septicemia in fish.
AdipoGen C7-L-HSL
Chemical. CAS 177158-20-2. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence, infection prevention and septicemia in fish.
AdipoGen Lisofylline
Chemical. CAS 6493-06-7. Formula C13H20N4O3. MW 280.3. Synthetic. Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the − optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase LPAAT, which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.
AdipoGen Tyramine
Chemical. CAS 51-67-2. Formula C8H11NO. MW 137.2. Synthetic. Tyramine is a naturally-occurring trace amine derived from the amino acid tyrosine that is produced endogenously or can be obtained from certain foods. Tyramine acts as a catecholamine releasing agent. It is unable to cross the blood-brain barrier, resulting in only non-psychoactive peripheral sympathomimetic effects following ingestion. Acts as a adrenergic and activates trace amine-associated receptor 1. Tyramine also inhibits the release of norepinephrine and dopamine. It is metabolized by monoamine oxidase A. Primarily used as an intermediate in the manufacture of pharmaceutical and agrochemical products.
AdipoGen Folic acid
Chemical. CAS 59-30-3. Formula C19H19N7O6. MW 441.4. Synthetic. Folic acid, also known as folate, is a B vitamin is an essential nutritional component of the human diet. It is necessary for the production and maintenance of new cells, for DNA synthesis and RNA synthesis, and for preventing changes to DNA, and consequently cancer. It is especially important during periods of frequent cell division and growth, such as infancy and pregnancy. Folate is needed to carry one-carbon groups for methylation reactions and nucleic acid synthesis. Folic acid deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. Both adults and children need folate to make normal red and white blood cells and prevent anemia. Deficiency of folic acid in pregnant women has been implicated in neural tube defects NTD.
![OBORO LABS INC CAS# 1007375-02-1. 1 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol](https://assets.fishersci.com/TFS-Assets/CCG/product-images/Oboro2.jpg-250.jpg)
OBORO LABS INC CAS# 1007375-02-1. 1 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
CAS# 1007375-02-1. 1 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
OBORO LABS INC CAS# 1007375-08-7. 1 g. OCO-Me Pincer Ligand, 99%. IUPAC Name: 1,1′:3′,1′′-Terphenyl, 3,3′′-bis(1,1-dimethylethyl)-2,2′′-dimethoxy-
CAS# 1007375-08-7. 1 g. OCO-Me Pincer Ligand, 99%. IUPAC Name: 1,1′:3′,1′′-Terphenyl, 3,3′′-bis(1,1-dimethylethyl)-2,2′′-dimethoxy-
OBORO LABS INC CAS# 1007375-02-1. 500 mg. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
CAS# 1007375-02-1. 500 mg. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
OBORO LABS INC CAS# 1007375-02-1. 5 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
CAS# 1007375-02-1. 5 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol