A zwitterionic non-detergent sulfobetaine; improves the renaturation yield of unfolded hen lysozyme or the unfolded β2 subunit of E. coli tryptophan synthase at 0.6 and 1 M, respectively, in renaturation buffer; enhances electron extraction and transport, improves interfacial contact, and increases power conversion efficiency when used to modify the tin oxide electron transport layer in inverted organic solar cells at 0.2 mg/ml