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4-Thio-UTP is a nucleotide triphosphate analog in which the oxygen atom at the 4-position of uracil is substituted by a sulfur atom It can be incorporated into RNA molecules during in vitro transcription reactions producing RNAs containing 4-thiouridine modifications This modification provides unique advantages in studying protein interactions RNA modifications and RNA labeling Due to the presence of the sulfur atom RNA modified with 4-Thio-UTP can form cross-links with proteins upon ultraviolet (UV) irradiation facilitating the study of RNA-protein interactions Additionally 4-Thio-UTP can be employed in research on RNA folding and function as well as in studying the cellular localization and roles of RNA
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UDP-GalNAz disodium is an azide-bearing nucleotide sugar analogue (UDP-N-azidoacetylgalactosamine disodium) used as a donor substrate for N-acetylgalactosaminyltransferases and as a bioorthogonal reagent for azide-alkyne click chemistry. Supplied as the water-soluble disodium salt, it is intended for in vitro glycosylation, biochemical assays, and click-conjugation workflows requiring an azide-functionalized UDP-sugar.
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A fluorescently tagged form of dUTP; can be used to generate fluorescently labeled DNA via reverse transcription, nick translation, random primed labeling, or PCR; has been used to detect nucleic acids in situ; ex/em = 498/517 nm, respectively
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YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor YTX-465 inhibits Ole1 and SCD1 with IC50s of 0 039 M and 30 4 M respectively YTX-465 can be used in the research of Parkinson s disease and other synucleinopathies[1]
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2’-OMe- RNA Thiophosphoramidites are RNA monomers designed to produce oligos combining the PS2 linkage with the 2’-O-methyl ribose modification. These PS2-modified RNA oligos have potential for use in siRNAs and dithiophosphate aptamers (thioaptamers).
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