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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
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Ara-CTP is a sugar-modified nucleoside analogue composed of cytosine attached to arabinose phosphorylated as a triphosphate Ara-CTP exerts its biological activity primarily by incorporating into nucleic acid strands during nucleic acid synthesis thereby interfering with DNA polymerase and RNA polymerase activities Upon integration Ara-CTP disrupts nucleic acid elongation and replication steps resulting in strand termination or abnormal formation Based on these pharmacological properties Ara-CTP holds research potential in antiviral studies investigating viral replication mechanisms evaluating polymerase specificity identifying viral enzyme inhibitors and serving as a probe in biochemical assays exploring nucleotide-binding interactions and nucleic acid synthesis fidelity
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