Nucleotides
Sigma Aldrich Fine Chemicals Biosciences Deoxynucleotide Mix 10 mM
Nucleotides are organic molecules that serve as the monomers or subunits of nucleic acids (like DNA and RNA). The building blocks of nucleic acids nucleotides consist of a nitrogenous base (purine or pyrimidine) a five-carbon sugar (ribose or deoxyribose) and at least one phosphate group. A nucleoside along with a phosphate group yields a nucleotide.
Cayman Chemical AICA Ribonucleotide, Purity: ≥95%, CAS: 3031-94-5, 10 mg
An AMPK activator; activates AMPK in a cell-free assay from 1-500 µM; inhibits lipolysis and lipogenesis in primary rat adipocytes from 100-500 µM; increases insulin sensitivity and prevents pancreatic β-cell damage in Zucker diabetic fatty rats at 0.5 mg/kg; induces cardiac mobilization and myofibroblast differentiation of endogenous CD44+CD45-/- MSCs, as well as decreases cardiac scar formation, in an aged mouse model of LAD occlusion-induced myocardial infarction at 0.5 mg/kg
Medchemexpress LLC FAM-labeled ODN 1826 sodium | 00-00-0 | 98.0% | 5 MG
FAM-labeled ODN 1826 sodium is a class B CpG oligodeoxynucleotide that functions as a TLR9 agonist and is labeled with fluorescein (FAM) for fluorescence-based studies. It is supplied as a light yellow solid for research use and is intended for evaluating cellular uptake and localization by confocal microscopy or flow cytometry.
- Class B CpG oligodeoxynucleotide.
- TLR9 agonist to stimulate innate immune responses.
- Fluorescein (FAM) label enables fluorescent detection.
- High purity (98.03%) and solid, light yellow appearance.
- Storage: -20°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
Cayman Chemical Grnzyme B MoncLNal ntIbod 50uL
An a-glucosidase inhibitor (IC50 0.7 Ug/ml) and a prodrug form of castanospermine reduces BVDV levels in a plaque formation assay (IC50 16 mM) and increases survival of MDBK infected with BVDV (IC50 47 UM) reduces viremia and increases survival of mice infected with a lethal dose of dengue virus at 50 mg/kg twice daily i.p.
Medchemexpress LLC p-SCN-Bn-NOTA trihydrochloride | 1583289-85-3 | MFCD35595284 | 99.6% | 559.89 | C20H29Cl3N4O6S | 5mg
p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells mediating tumor enrichment of radioactive probes p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR such as prostate cancer and colorectal cancer[1][2]
Apexbio Technology LLC Biotin-16-UTP 200ul (10 mM)
Biotin-16-UTP is a biotin-labeled uridine triphosphate used for RNA detection and purification The biotin label allows RNA molecules to bind with streptavidin or anti-biotin proteins facilitating specific RNA detection and purification In in vitro transcription reactions Biotin-16-UTP can be incorporated into RNA molecules generating biotin-labeled RNA This labeled RNA has wide applications in RNA-protein interaction studies RNA detection and RNA purification Additionally biotin-labeled RNA can be applied in in vivo experiments to investigate RNA localization and function within cells
AURORA BIOLABS LLC Kras WT, GppNHp loaded, 100 μg
Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Cayman Chemical Tubercidin, Purity: ≥98%, CAS: 69-33-0, 5 mg
A nucleoside analog with diverse biological activities; active against S. faecalis (IC50 = 0.02 µM); cytotoxic to P388 and A549 cells (IC50s = 0.008 and 0.019 µg/ml, respectively); reduces infection of Calu-3 cells by SARS-CoV-2 (EC50 = 0.05 µM) but is toxic to A549-ACE2 and Vero cells; increases survival in a mouse model of schistosomiasis when used at 5 mg/kg in combination with NBMPR-P but is toxic and induces mortality when administered alone at the same dose for four days
eMolecules 25899-70-1 | Medchem Express | Xanthosine 5-monophosphate (sodium salt) | 50mg | 642185150 | HY-W008990 | 408.17 | C10H11N4Na2O9P
Ambeed | 2-Chloro-3-(trifluoromethyl)aniline | 5g | 626256708 | A1481653 | 62476-58-8 | MFCD04115988 | 195.570 | C7H5ClF3N
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Apexbio Technology LLC 5-Propargylamino-dCTP 100ul (100 mM)
5-Propargylamino-dCTP is a modified nucleoside triphosphate analog featuring a cytosine base with a propargylamino substituent introducing an alkyne functional group 5-Propargylamino-dCTP is incorporated into DNA strands mediated by DNA polymerases during active DNA synthesis This modification enables covalent conjugation to azide-bearing probes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) Based on these pharmacological properties 5-Propargylamino-dCTP holds research potential in the detection and analysis of cellular proliferation DNA replication dynamics nucleic acid repair subcellular localization studies fluorescence labeling and molecular imaging-based nucleic acid research methodologies
Medchemexpress LLC cGAMP (diammonium) | 96.63% | 708.47 | 25 MG
cGAMP (Cyclic GMP-AMP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It activates stimulator of interferon genes (STING), which leads to a signaling cascade that produces type I interferons and other immune mediators.
- Functions naturally in metazoans
- Responds to cytosolic DNA by triggering interferon production
- Activates STING, initiating a signaling cascade for type I interferons and other immune mediators
- Promotes the antigen-specific proliferation capacity of spleen cells in mice
- Directly activates murine and human dendritic cells in vitro
- Induces an antiviral state and secretion of type I IFNs
- Promotes antigen-specific cytokine production by spleen cells of immunized mice
Abcam Thymidine, Pyrimidine deo x ynucleoside, 25G
MW 242.23 Da, Purity >98%. Pyrimidine deoxynucleoside. Potent thymidine kinase substrate (IC₅₀ = 16 nM). Pairs with deoxyadenosine in double-stranded DNA. Synchronizes cells in S phase in vivo. .
The product is subject to the following: Abcam Restricted Use Statement