Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical SaIkosaponIn A 5mg
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A triterpenoid saponin with diverse biological activities; reduces expression of TNF-α, IL-6, and IL-1β in LPS-stimulated primary mouse macrophages; increases the survival rate in mice with LPS-induced lethal endotoxemia; reduces weight loss, brain edema, blood-brain barrier disruption, and cortex IL-6 and TNF-α protein levels in the ipsilateral cortex in a rat model of traumatic brain injury at 20 mg/kg; reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo at 8 mg/kg; reduces duration and frequency of epileptiform discharges in rat hippocampal CA1 neurons in a 4-AP seizure model; decreases viability in six HCC, H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines at 20 µM; prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo at 2 mg/kg
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STEMCELL Technologies AZD8055, Size: 10 mg
Selectively inhibit mammalian target of rapamycin (mTOR) with AZD8055 (Chresta et al. Cancer Res, 2010). This mTOR pathway inhibitor is widely used in cancer research to inhibit proliferation in different cancer cell lines, such as the A549 and H838 small-cell lung cancer cell lines (Chresta et al. Cancer Res, 2010), the Hep-2 human laryngeal cancer cell line (Zhao et al. Int J Clin Exp Med, 2014), and the HeLa human cervical cancer cell line (Li et al. Oncol Lett, 2013). In combination with ABT-737, AZD8055 induces apoptosis in rhabdomyosarcoma (RMS) cells (Preuss et al. J Biol Chem, 2013). It also inhibits cell proliferation, increases cell death, and reduces migration in tamoxifen-resistant and estrogen deprivation-resistant breast cancer cell lines (Jordan et al. Breast Cancer Res, 2014). AZD6244 is supplied as a crystalline solid with ≥98% purity; Molecular weight 465.5 g/mol; CAS Number 1009298-09-2. Visit STEMCELL.com for more information and related products.
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Cayman Chemical ANTIBODY RN-1747 10mg
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A TRPV4 agonist; selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or TRPM8 (EC50s = >100, >30, and >30 µM, respectively); induces inward current in Xenopus oocytes expressing human TRPV4 at 10 µM; topical administration of RN-1747 induces hypothermia in rats
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Selleck Chemical LLC Emilia Sonchifolia Extract E3816-5MG
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Emilia Sonchifolia Extract is extracted from Emilia sonchifolia which is a potent immune response modulator
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Selleck Chemical LLC L-Sulforaphane E4007-5MG
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L-Sulforaphane ((R)-Sulforaphane) is a highly potent inducer of the Keap1/Nrf2/ARE pathway It is a more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer
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Selleck Chemical LLC Cherry Powder Extract E3831-5MG
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Cherry Powder Extract (Pink) Extract is extracted from Prunus avium which has anti-oxidant and anti-inflammatory properties
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Selleck Chemical LLC Culmerciclib E4703-5MG
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Culmerciclib (TQB3616) is a potent inhibitor of cyclin dependent kinase (CDK)4/6 and exhibits highly effective antineoplastic activity TQB3616 exhibits significant synergistic antitumor activity in estrogen receptor (ER)-positive/HER2-negative or HER2-positive breast cancer when combined with endocrine therapy or Human Epidermal Growth Factor Receptor 2 (HER2) targeted therapy
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Selleck Chemical LLC GNE-495 E4722-100MG
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GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3 7 nM It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model
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Selleck Chemical LLC NSC15364 S0231-5MG
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NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization concomitant with an inhibition of apoptosis
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Selleck Chemical LLC CDK2-IN-73 S0273-10MM/1ML
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CDK2-IN-73 (CDK2-IN-4 CDK2 inhibitor 73) is a potent and selective inhibitor of CDK2 with IC50 of 44 nM for CDK2/cyclin A
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Selleck Chemical LLC Pronase E E8154-100MG
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Pronase E (Activity 7000 U/g) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids
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Cayman Chemical ANTIBODY 9 R-PAHSA 1mg
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A stereoisomer of 9-PAHSA; the predominant form of 9-PAHSA that accumulates in adipose tissue in vivo; cell lines favor the production of 9(R)-PAHSA
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Apexbio Technology LLC LKB1 (AAK1 dual inhibitor) 1093222-27-5 50mg
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LKB1 (AAK1 dual inhibitor CAS 1093222-27-5) is a selective inhibitor targeting both LKB1 kinase and adaptor-associated kinase 1 (AAK1) These kinases are serine/threonine protein kinases implicated in cellular metabolism polarity and endocytic trafficking pathways respectively By simultaneously inhibiting LKB1 and AAK1 activity this small molecule modulates diverse intracellular signaling cascades associated with cell proliferation and membrane trafficking Due to these mechanistic features LKB1 (AAK1 dual inhibitor) serves as a valuable research tool for studying kinase-associated pathways in various biomedical contexts and potentially informing therapeutic strategies
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Cayman Chemical Pntoprazole sulfon 5mg
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A pantoprazole metabolite; formed by CYP2C19 and CYP3A4 metabolism of pantoprazole
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Medchemexpress LLC Jdq-443-10Mg | HY-139612-10MG
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Jdq-443-10Mg
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