Bioactive Small Molecules
Cayman Chemical Pap12-6 (trifluoroacetate salt), Purity: ≥95%, 5 mg
An antibacterial peptide; active against a panel of eight Gram-negative bacteria, including E. coli, P. aeruginosa, and S. syphimurium (MIC50s = 4-8 µM), and the Gram-positive bacteria S. aureus, MRSA-3126, B. subtilis, and S. epidermidis (MIC50s = 4-8 µM) without affecting the viability of human erythrocytes, RAW 264.7 macrophages, HaCaT keratinocytes, or HEK293 kidney cells at 25 µM; induces membrane depolarization in E. coli at 4 and 8 µM; preincubation reduces NO2-, Tnf-α, and Il-6 secretion levels in LPS-stimulated RAW 264.7 macrophages at 10 µM; increases survival in E. coli-infected mice infected at 10 mg/kg; reduces the number of CFUs in the lungs, liver, and kidneys in E. coli-infected mice at 1 mg/kg; reduces serum AST and ALT levels and blood urea nitrogen levels in a mouse model of E. coli-induced sepsis at 1 mg/kg
Selleck Chemical LLC V-9302 S8818-100MG
V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9 6 M for inhibition of glutamine uptake in HEK-293 cells V-9302 blocks Sodium-neutral AA transporter 2 (SNAT2 SLC38A2) and the large neutral AA transporter 1 (LAT1 SLC7A5) as observed in 143B osteosarcoma cells HCC1806 breast cancer cells and Xenopus laevis oocytes Dilution of PBS may cause a clear aqueous solution to turn into a uniform suspension
eMolecules Medchem Express | Mitochondrial respiration-IN-1 (hydrobromide) | 5mg | 569407521 | HY-131453A | 607.34 | C26H26Br2NO2PS
Medchem Express | Mitochondrial respiration-IN-1 (hydrobromide) | 5mg | 569407521 | HY-131453A | | 607.340 | C26H26Br2NO2PS
AdipoGen (+)-Biotin N-hydroxysuccinimide ester (100 mg)
Chemical. CAS: 35013-72-0. Formula: C14H19N3O5S. MW: 341.38. Biotin succinimidyl ester is the most popular amine-reactive biotinylating agent for modifying proteins, peptides, antibodies, oligonucleotides, microbeads and other biological molecules. It forms irreversible amide bonds. Typically coupled to primary amine in the pH range 6.5-8.5. This cell-permable activated biotin derivative can be readily coupled to primary or secondary amines of analyte compounds or proteins under mild conditions. The resulting biotinylated derivatives have been widely used in streptavidin or avidin systems and labeling methods, with many applications in immunology and histochemistry. It is used to selectively label Escherichia coli cell envelope proteins in vivo. It preferentially labels outer membrane, periplasmic, and inner membrane proteins as well as a specific inner membrane marker protein (Tet-LacZ).
Cayman Chemical K-7174 (hydrochloride), Purity: ≥98%, CAS: 191089-60-8, 5 mg
A 20S proteasome inhibitor; inhibits the 20S proteasome β1, β2, and β5 catalytic subunits at 5 µM; reduces TNF-α- or IL-1β-induced adherence of U937 monocytes to HUVECs at 10 µM; inhibits tumor growth in U266 and RPMI-8226 multiple myeloma mouse xenograft models at 75 mg/kg; an inhibitor of the GATA consensus sequence
Cayman Chemical BTTAA, Purity: ≥98%, CAS: 1334179-85-9, 10 mg
A click chemistry Cu(I)-stabilizing ligand and catalyst; displays an increased CuAAC rate in a propargyl alcohol and 3-azido-7-hydroxycoumarin reaction, as well as an increased yield, compared to the click chemistry ligands BTTES, THPTA, and TBTA in a fluorogenic assay; has been used with biotin-azide in CuAAC for the labeling and detection of azide-tagged glycoconjugates in Jurkat cells, zebrafish, and bacteria
eMolecules 602306-29-6 | AZD5438 | MFCD11112135 | 100mg
Ambeed | AZD5438 | 100mg | 552733330 | A457556 | 602306-29-6 | MFCD11112135 | 371.460 | C18H21N5O2S
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Cayman Chemical Tirasemtiv, Purity: ≥98%, CAS: 1005491-05-3, 5 mg
An activator of the fast skeletal troponin complex; selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes; slows the rate of calcium release from the fast skeletal troponin complex at 20 μM; increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM); sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium; increases in situ EDL muscle force and forelimb grip strength in a rat model of myasthenia gravis; increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of ALS at 10 mg/kg
Cayman Chemical BAY-1436032, Purity: ≥98%, CAS: 1803274-65-8, 10 mg
An inhibitor of mutant IDH1 (IC50 = 0.015 µM for both IDH1R132H and IDH1R132C); selective for mutant IDH1 over wild-type IDH1 and IDH2 (IC50s = 20 and >100 µM, respectively); inhibits 2-HG production in HEK293 cells expressing IDH1R132H, IDH1R132C, IDH1R132G, IDH1R132S, and IDH1R132L; inhibits 2-HG production in LN-229 and HCT116 cells overexpressing IDH1R132H (IC50s = 73 and 47 nM, respectively), as well as in HT-1080 cells endogenously expressing IDH1R132C (IC50 = 135 nM); reduces tumor growth and increases survival in an NCH551b IDH1R132H mutant secondary glioblastoma PDX model at 150 mg/kg; also induces myeloid differentiation of IDH1R132C mutant AML cells in mice at 45 and 150 mg/kg
Medchemexpress LLC N-Acetylguanosine | 21967-06-6 | 99.7% | 325.28 | 5 MG
Ac-rG (N-Acetylguanosine) is an acetylated guanosine ribonucleotide. It is intended for research use only and not for patient use.
- For research use only.
- Not for sale to patients.
Apexbio Technology LLC Mercaptopurine (6-MP) 50-44-2 10mM (in 1mL DMSO)
Mercaptopurine (6-MP CAS 50-44-2) is a purine analog that disrupts de novo purine biosynthesis by incorporating into nucleic acids thereby inhibiting DNA and RNA synthesis This mode of action results in cytotoxic and immunosuppressive effects making the compound a valuable tool in studies of cell proliferation immune response modulation and leukemia research 6-MP serves as the active metabolite of azathioprine and it is also used to investigate the interaction between purine metabolism inhibitors and anticoagulant agents such as warfarin
Medchemexpress LLC (2S,3R,4S)-4-Hydroxyisoleucine | 55399-93-4 | 850083 | >98.0% | 147.17 | 1 ML
(2S,3R,4S)-4-Hydroxyisoleucine | 55399-93-4 | 850083 | >98.0% | 147.17 | 1 ML
AdipoGen Naproxen Solution (5 ml)
Chemical. CAS: 22204-53-1. Formula: C14H14O3. MW: 230.26. Naproxen is a potent, non-steroidal, non-selective anti-inflammatory cyclooxygenase (COX-1 and COX-2) inhibitor. Inhibits COX-1 expression in HUVECS at a concentration of 5µg/ml. This COX inhibitor is indicated for the treatment of pain, fever, inflammation and stiffness. Research indicates that the S-naproxen is a more active form than the R-naproxen. The S-naproxen enantiomer was observed to inhibit platelet aggregation, and both enantiomers decrease production of thromboxane B2. Naproxen has been demonstrated to block A? fibril growth and form a complex with copper (II).
Medchemexpress LLC H-20 | 3020015-02-2 | 99.6% | 973.04 | 10 MG
H-20 is a PD-1 agonist that can be used in the research of chronic pain. It is a solid, white to off-white in color, with the sequence Ile-Ser-Tyr-Gly-Gly-Ala-Asp-Tyr-Lys.
- Acts as a PD-1 agonist
- Suitable for chronic pain research
- Solid appearance
- White to off-white color
- Features the sequence Ile-Ser-Tyr-Gly-Gly-Ala-Asp-Tyr-Lys
Medchemexpress LLC Osteogenic growth peptide, ogp | 132996-61-3 | 99.2% | 1523.74 | 5 MG
Osteogenic Growth Peptide (OGP) is a naturally occurring 14-mer growth factor peptide found in serum. It is designed for research use, regulating proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. Its active portion, OGP(10-14), binds to the OGP receptor, activating MAP kinase, Src, and RhoA pathways. OGP's primary structure is identical to the C-terminus of histone H4, and it is isolated from blood during osteogenic remodeling.
- Naturally occurring 14-mer growth factor peptide
- Regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells
- Active portion OGP(10-14) activates MAP kinase, Src, and RhoA pathways
- Primary structure identical to the C-terminus of histone H4
- Stimulates proliferation, differentiation, alkaline phosphatase activity, and matrix mineralization of osteoblastic lineage cells
- For research use only