Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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916
Tocris Bioscience™ 6877002
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CD40-TRAF6 interaction inhibitor
| Target | Additional Cytokine Receptor Products |
|---|---|
| CAS | 433249-94-6 |
| Purity | >99% |
| Chemical Name or Material | 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C17H17NO |
| Formula Weight | 251.32 |
917
Tocris Bioscience™ VO-OHpic
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent PTEN inhibitor
| Inhibitors | VO-OHpic |
|---|---|
| Product Type | VO-OHpic |
| Molecular Weight (g/mol) | 361.16 |
| Purity | >98% |
918
Tocris Bioscience™ SJF 8240
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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c-MET PROTAC™; also degrades exon-14-deleted c-MET
919
Tocris Bioscience™ DCEBIO
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Activates Cl- conductance and hKCa3.1 channels
| CAS | 60563-36-2 |
|---|---|
| Solubility | Soluble to 100mM in DMSO |
| Chemical Name or Material | 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C9H8Cl2N2O |
| Formula Weight | Observed MW: 231.08 |
| Assay Percent Range | >99% |
920
Tocris Bioscience™ JW 74
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Wnt pathway inhibitor
| CAS | 863405-60-1 |
|---|---|
| Solubility | Soluble to 100mM in DMSO |
| Purity | >99% |
| Chemical Name or Material | 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C24H20N6O2S |
| Formula Weight | Observed MW: 456.52 |
921
Tocris Bioscience™ SJF 1528
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent EGFR PROTAC™; also degrades HER2
922
Tocris Bioscience™ SJFa SJFalpha SJFalpha
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent and selective p38α PROTAC™
923
Tocris Bioscience™ Tetrabenazine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent inhibitor of vesicular monoamine transport
| Inhibitors | Tetrabenazine |
|---|---|
| Product Type | Tetrabenazine |
| Molecular Weight (g/mol) | 317.2 |
| Purity | >98% |
924
Tocris Bioscience™ M 084 hydrochloride
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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TRPC4/5 channel blocker; antidepressant and anxiolytic
| Target | TRPC Channel Blockers |
|---|---|
| CAS | 1992047-63-8 |
| Purity | >99% |
| Chemical Name or Material | N-Butyl-1H-benzimidazol-2-amine hydrochloride |
| Recommended Storage | Desiccate at Room Temperature |
| Molecular Formula | C11H15N3.HCl |
| Formula Weight | 225.72 |
925
Tocris Bioscience™ Ex 26
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Potent and selective S1P1 receptor antagonist
| CAS | 144678-63-7 |
|---|---|
| Product Type | Bioactive Small Molecule |
| Color | White |
| Solubility | Soluble to 100mM in DMSO and to 100mM in ethanol |
| Purity | >98% |
| Physical Form | Solid |
| Chemical Name or Material | 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylic acid |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C28H28ClFN2O3 |
| Formula Weight | 494.98 |
926
Tocris Bioscience™ Valsartan
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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High affinity, selective AT1 antagonist
| Inhibitors | Valsartan |
|---|---|
| Product Type | Valsartan |
| Molecular Weight (g/mol) | 435.52 |
| Purity | >99% |
927
Tocris Bioscience™ Mirtazapine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 85650-52-8 Molecular Formula: C17H19N3
| CAS | 85650-52-8 |
|---|---|
| Molecular Formula | C17H19N3 |
928
Tocris Bioscience™ Rp-8-Br-PET-cGMPS
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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CAS: 185246-32-6 Molecular Formula: C18H15BrN5NaO6PS
| CAS | 185246-32-6 |
|---|---|
| Molecular Formula | C18H15BrN5NaO6PS |
929
Tocris Bioscience™ BAY 6035
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent and selective SMYD3 inhibitor
| Product Type | Inhibitor |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C22H28N4O3 |
| Formula Weight | 396.48 |
930
Tocris Bioscience™ GSK 2194069
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent human fatty acid synthase (hFASN) inhibitor
| CAS | 1332331-08-4 |
|---|---|
| Chemical Name or Material | 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C25H24N4O3 |
| Formula Weight | Observed MW: 428.48 |
| Assay Percent Range | >99% |