Protein Modification Reagents
Avanti Polar Lipids DSPE-PEG(2000) AZIDE 50MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt) 50mg
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g·mol⁻1 | C57H75N9O21 | 50 MG
Azide-PEG4-VC-PAB-doxorubicin is an antibody-drug conjugate (ADC) agent-linker conjugate that couples the cytotoxic anthracycline doxorubicin to an azide-terminated PEG4-VC-PAB linker for use in bioconjugation and ADC assembly. It is designed for click chemistry conjugation (CuAAC and SPAAC) to alkyne- or DBCO/BCN-containing partners and is supplied as a solid for research use.
Medchemexpress LLC Ald-ph-amido-PEG4-C2-NHS ester | 1353011-74-1 | 98.1% | 494.49 g/mol | C23H30N2O10 | 50 MG
A noncleavable, four-unit polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester functional group designed for antibody-agent conjugation and general bioconjugation applications. The linker provides PEG spacing and a reactive NHS ester for coupling to primary amines; it is supplied as a solid and is intended for research use only.
- Noncleavable 4-unit PEG linker.
- NHS ester reactive toward primary amines.
- Suitable for antibody-agent conjugation and bioconjugation workflows.
- Molecular weight approximately 494.49 g/mol.
- CAS number 1353011-74-1.
Medchemexpress LLC Bromo-PEG2-C2-azide | 530151-56-5 | MFCD25424115 | 98.7% | 238.08 g·mol⁻1 | C6H12BrN3O2 | 100 MG
Bromo-PEG2-C2-azide is a PEG-based bromo azide linker used as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PROTAC linker. It contains an azide functional group for click chemistry and a bromoalkyl handle for further functionalization. Molecular formula C6H12BrN3O2; molecular weight 238.08 g·mol⁻1; purity ≥98.7%.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Provides a bromoalkyl handle for alkylation or substitution reactions.
- Suitable as a non-cleavable linker for ADC synthesis and as a PROTAC linker.
- High purity for reliable synthetic performance.
- Available in small lab quantities for research use.
![eMolecules 2149585-17-9 | DNP-PEG4-DBCO | Broadpharm689.722 | C35H39N5O10 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(c1)[N+]([O-])=O | 250mg | 550804480](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183475.JPG-250.jpg)
eMolecules 2149585-17-9 | DNP-PEG4-DBCO | Broadpharm689.722 | C35H39N5O10 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(c1)[N+]([O-])=O | 250mg | 550804480
DNP-PEG4-DBCO | Broadpharm | 2149585-17-9689.722 | C35H39N5O10 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCOCCC(=O)NCCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(c1)[N+]([O-])=O | 250mg | 550804480
eMolecules 811442-84-9 | t-Boc-N-amido-PEG4-amine | Broadpharm | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 25g | 893909427
t-Boc-N-amido-PEG4-amine | Broadpharm | 811442-84-9 | MFCD16619339 | 336.429 | C15H32N2O6 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCN | 25g | 893909427
Medchemexpress LLC ICG-alkyne | 1622335-41-4 | C48H53N3O4S | 5 MG
ICG-alkyne is a click chemistry reagent containing an azide group.
- Click chemistry reagent
- Contains an azide group
eMolecules 141282-35-1 | Medchem Express | Amino-PEG5-CH2COOH | 50mg | 673358879 | HY-130577 | MFCD27977526 | 295.332 | C12H25NO7
Ambeed | N1N2-Didodecyl-N1N1N2N2-tetramethylethane-12-diaminium bromide | 250mg | 491662680 | A367005 | 18464-23-8 | MFCD01861906 | 614.680 | C30H66Br2N2
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Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 25 MG
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker. The connector of the linker is a Halogen group. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
- Conjugate of ligands for E3 and 16-atom-length linker.
- Connector of linker is halogen group.
- Incorporates the VH285 based VHL ligand and an alkyl/ether-based linker.
- Treatment with 500 nM can induce nearly complete knockdown of both HaloTag7-ERK1 and HaloTag7-MEK1.
eMolecules 867062-95-1 | FmocNH-PEG3-CH2CH2COOH | Acrotein ChemBio Inc. | MFCD06656471 | 443.496 | C24H29NO7 | 97.000 | OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 487561655
FmocNH-PEG3-CH2CH2COOH | Acrotein ChemBio Inc. | 867062-95-1 | MFCD06656471 | 443.496 | C24H29NO7 | 97.000 | OC(=O)CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 1g | 487561655
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 50 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker.
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG24-CH2CH2COOH | 25 g | CAS 2170484-59-8 | MDL MFCD11041159
Fmoc-NH-PEG24-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2170484-59-8
- MDL: MFCD11041159
- InChIKey: NFOMZHGRFWXDGH-UHFFFAOYSA-N
- Molecular Weight: 1368.609
- Molecular Formula: C66H113NO28
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxa-4-azanonaheptacontan-79-oic acid
- SMILES: OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)=O
Medchemexpress LLC (S,R,S)-AHPC-C2-PEG3-BCN | 2876198-36-4 | 98.4% | 810.01 | 5 MG
(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is described as a VHL ligand that can be utilized for the synthesis of PROTACs. It is intended for research use only.
- VHL ligand
- Utilized for the synthesis of PROTACs
- White to light yellow solid
eMolecules 1202761-21-4 | Medchem Express | Biotinyl-NH-PEG3-C3-amido-C3-COOH | 50mg | 721772050 | HY-130142A | 560.71 | C25H44N4O8S
ChemScene | 3-(4-Bromo-3-fluoro-phenyl)-propionic acid | 100mg | 572181076 | CS-0059887 | 127425-80-3 | MFCD18391366 | 247.063 | C9H8BrFO2
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