Protein Modification Reagents
Medchemexpress LLC Mal-amido-PEG8-NHS ester | 756525-93-6 | MFCD11041144 | 99.2% | 689.71 g/mol | C30H47N3O15 | 50 MG
Mal-amido-PEG8-NHS ester is a bifunctional PEG-based linker bearing a maleimide and an NHS ester. It is designed for bioconjugation workflows to connect thiol- and amine-containing molecules, enabling assembly of PROTACs, antibody drug conjugates, and other conjugates. The PEG8 spacer improves solubility and flexibility, while the reactive termini support efficient, site-selective coupling.
Medchemexpress LLC PROTAC EGFR degrader 9 | 2992670-33-2 | 98.4% | 899.98 | 5 MG
PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. It demonstrates a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. This degrader exhibits potent degradation activity against various EGFR mutants while sparing EGFRWT. The compound is for research use only and not sold to patients.
- Orally active CRBN-based PROTAC EGFR degrader.
- Exhibits potent degradation activity against various EGFR mutants (EGFRL858R/T790M/C797S, EGFRdel19 T790M C797S, EGFRL858R/T790M, EGFRdel19).
- Spares EGFRWT.
- Inhibits NSCLC tumor growth in vivo without obvious toxicity.
- Reduces EGFR protein level and inhibits EGFR phosphorylation in tumor tissues.
- Arrests H1975-TM cells in the G0/G1 phase.
- Promotes cell apoptosis in H1975-TM cells.
Medchemexpress LLC Amino-tri-(azide-PEG4-ethoxymethyl)-methane | 99.8% | 1070.20 | 5 MG
Amino-tri-(azide-PEG4-ethoxymethyl)-methane is a multi-arm PEG product, synthesized with high purity of 99.81% to ensure reliable experimental results. This versatile chemical reagent is designed exclusively for research applications.
- High purity, verified at 99.81%.
- Features a multi-arm polyethylene glycol structure.
- Available in multiple quantities to suit diverse research requirements.
- Packaged for stable room temperature shipping.
- Accompanied by comprehensive documentation for reference and safety.
Medchemexpress LLC PROTAC BTK Degrader-10 | 2988804-46-0 | 771.91 | 5 MG
PROTAC BTK Degrader-10 is a PROTAC degrader for BTK. It can be used for research of chronic lymphocytic leukemia (CLL). It consists of a pink ligand for target protein (HY-170758), a black linker (HY-W392857), and a blue ligand for E3 ligase Cereblon (HY-W733176).
- PROTAC degrader for BTK
- Applicable for research on chronic lymphocytic leukemia (CLL)
Medchemexpress LLC (S,R,S)-AHPC-PEG2-NH2 | 2010159-60-9 | 95.4% | 575.72 g·mol⁻¹ | C28H41N5O6S | 50 MG
(S,R,S)-AHPC-PEG2-NH2 is an E3 ligase VHL ligand-linker conjugate that links an (S,R,S)-configured AHPC VHL ligand to a two-unit polyethylene glycol (PEG2) spacer ending in a primary amine, used as a building block in PROTAC synthesis.
- VHL ligand-linker conjugate for targeted protein degradation research.
- Contains an (S,R,S)-configured AHPC VHL ligand.
- Features a two-unit PEG linker terminating in a primary amine for conjugation.
- Provided as a free base solid, typically white to yellow.
- Available in small research pack sizes suitable for synthesis workflows.
- High reported purity appropriate for medicinal chemistry and probe synthesis.
Medchemexpress LLC Dmg-peg-mal (mw 2000) | 99.3% | 2000 (Average) | 50 MG
DMG-PEG-Mal (MW 2000) is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. It is suitable for use in drug delivery research.
- Improves delivery efficiency of poorly soluble drugs
- Enhances tissue specificity for poorly soluble drugs
- Suitable for drug delivery research
Medchemexpress LLC DSPE-PEG-alkyne | 85.0% | 2000 | 5 MG
DSPE-PEG-alkyne (MW 2000) is a PEG lipid.
- Can improve the delivery efficiency of poorly soluble drugs.
- Can improve the tissue specificity of poorly soluble drugs.
- Can be used in drug delivery research.
![eMolecules Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502474111.JPG-250.jpg)
eMolecules Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2
Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2
(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472885.JPG-250.jpg)
eMolecules DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
Medchemexpress LLC Pomalidomide-PEG2-acetic acid | 2143097-05-4 | 99.4% | 419.39 | 25 MG
Pomalidomide-PEG2-acetic acid is a conjugate composed of an E3 ligase ligand and a linker. It can be used for PROTAC synthesis.
- Conjugate of an E3 ligase ligand and a linker
- Can be used for PROTAC synthesis
- Appearance: solid, light yellow to yellow