Protein Modification Reagents
Medchemexpress LLC Dmg-PEG-NHS | 95.0% | 2000 Da | 10 MG
NHS-activated polyethylene glycol (PEG) linker terminated with a dimyristoyl glycerol (DMG) lipid moiety and an N-hydroxysuccinimide (NHS) ester. Average molecular weight ~2,000 Da. Supplied as a white to off-white solid for research use; the NHS ester enables amine-reactive conjugation to proteins and other biomolecules and supports liposome and gene-delivery formulations.
- Enables efficient amine-reactive conjugation to proteins and peptides.
- Suitable for liposome formulation and surface PEGylation.
- Facilitates gene delivery and nucleic acid encapsulation.
- White to off-white solid, easy to handle and weigh.
- Stored as powder at -20°C for long-term stability; in-solution storage limited.
- High purity by NMR (95.0%), appropriate for research applications.
Medchemexpress LLC DSPE-PEG-biotin | 98.4% | 3,400 (average) | 50 MG
DSPE-PEG-Biotin is a PEGylated phospholipid conjugated to biotin for surface functionalization of liposomes, nanoparticles, and other amphiphilic assemblies. Its amphiphilic structure enables stable incorporation into lipid bilayers while presenting biotin for affinity capture and targeted delivery research.
- Average molecular weight 3,400.
- High purity (98.4%) for consistent experimental results.
- White powder form suitable for storage and handling.
- Provides a hydrophobic DSPE anchor and a hydrophilic PEG-biotin chain.
- Stable in powder form at -20°C; solutions require low-temperature storage.
- Available in small research quantities, such as 50 mg.
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 25 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds designed to degrade target proteins by exploiting the intracellular ubiquitin-proteasome system; they achieve this by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Degrades target proteins
- Exploits intracellular ubiquitin-proteasome system
- Connects a ligand for an E3 ubiquitin ligase with a ligand for the target protein
Medchemexpress LLC m-PEG-azide (MW 5000) | 98.0% | COCCOCCN=[N+]=[N-].[n].[MW 5000] | 50 MG
m-PEG-azide (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Click chemistry reagent.
- Contains an Azide group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc).
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
STA Pharmaceutical Fmoc-amino-PEG3-CH2COOH | 5 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
STA Pharmaceutical Fmoc-NH-PEG5-CH2COOH | 25 g | CAS 635287-26-2 | InChIKey LNIFRTLAPAPKAG-UHFFFAOYSA-N
Fmoc-NH-PEG5-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 635287-26-2
- MDL: No data
- InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
- Molecular Weight: 517.575
- Molecular Formula: C27H35NO9
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
eMolecules 2183440-36-8 | APN-C3-PEG4-alkyne | Broadpharm469.538 | C25H31N3O6 | 97.000 | O=C(CCOCCOCCOCCOCC#C)NCCCC(=O)Nc1ccc(cc1)C#CC#N | 5mg | 374905429
APN-C3-PEG4-alkyne | Broadpharm | 2183440-36-8469.538 | C25H31N3O6 | 97.000 | O=C(CCOCCOCCOCCOCC#C)NCCCC(=O)Nc1ccc(cc1)C#CC#N | 5mg | 374905429
(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502474728.jpg-250.jpg)
eMolecules DSPE-PEG-Boronate, MW 3,400 | Broadpharm |1045.130 | C53H95BFN2O14P | 98.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659
DSPE-PEG-Boronate, MW 3,400 | Broadpharm |1045.130 | C53H95BFN2O14P | 98.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(=O)NCc1ccc(cc1F)B(O)O)OC(=O)CCCCCCCCCCCCCCCCC | 100mg | 718091659
Enzo Life Sciences Gefitinib-based PROTAC 3 (1mg). CAS: 2230821-27-7
Gefitinib-based PROTAC 3 is targeting on EGFR, consisting of Gefitinib as the warhead linked to VHL-recruiting ligand. Purity: ≥99%. Solubility: Soluble in DMSO (75 mg/mL). Insoluble in water. Long Term Storage: -20°C.
eMolecules 134978-99-7 | Amino-PEG3-CH2CO2H | Broadpharm | MFCD24479841 | 207.226 | C8H17NO5 | 98.000 | NCCOCCOCCOCC(O)=O | 1g | 347153871
Amino-PEG3-CH2CO2H | Broadpharm | 134978-99-7 | MFCD24479841 | 207.226 | C8H17NO5 | 98.000 | NCCOCCOCCOCC(O)=O | 1g | 347153871
STA Pharmaceutical Fmoc-NH-PEG5-CH2COOH | 50 g | CAS 635287-26-2 | InChIKey LNIFRTLAPAPKAG-UHFFFAOYSA-N
Fmoc-NH-PEG5-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 50 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 635287-26-2
- MDL: No data
- InChIKey: LNIFRTLAPAPKAG-UHFFFAOYSA-N
- Molecular Weight: 517.575
- Molecular Formula: C27H35NO9
- Purity: ≥95%
- Container Type: 250 mL HDPE
- Pack Size: 50 g
- Net Weight: 50 g
- Gross Weight: 89.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC HOOC-PEG-SH MW 5000 5mg
HOOC-PEG-SH (MW 5000) (HOOC-PEG-Thiol (MW 5000)) is a reactive thiol PEG derivative with a terminal carboxyl group The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond The PEG linkage between the thiol and carboxyl groups has good water solubility flexible linker distance and higher stability[1]
Medchemexpress LLC 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ur... | 2722697-82-5 | MFCD00867744 | 99.9% | 1126.65 g·mol-1 | C55H68ClN11O13 | 5 MG
MC-VC-PABC-amide-PEG1-CH2-CC-885 is a neoDegrader-linker conjugate that couples a GSPT1-targeting degrader payload to a cleavable linker via a short PEG spacer. It is supplied as a research reagent for biochemical and cell-based studies of targeted protein degradation and assay development.
- NeoDegrader-linker conjugate designed for targeted protein degradation studies.
- GSPT1-targeting degrader payload for selective biological activity.
- Cleavable valine-citrulline PABC-type linker enabling intracellular payload release.
- Short PEG spacer improves solubility and linker flexibility.
- High reported purity suitable for research applications.
- Soluble in DMSO; may require sonication, use anhydrous DMSO for best results.
- Store at -20°C, protect from light; in solvent store at -80°C for long-term storage.
Medchemexpress LLC Acid-C2-PEG4-C2-NHS ester | 1343476-41-4 | 98.0% | 25 MG
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase and the other for the target protein
- Leverages the intracellular ubiquitin-proteasome system to selectively degrade target proteins