Protein Modification Reagents
eMolecules Mal-amido-PEG12-TFP ester | 1431295-77-0 | 250MG | Purity: 98%
Broadpharm | Mal-amido-PEG12-TFP ester | 250MG | 1431295-77-0 | MFCD27978401 | MW:82.39
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eMolecules 1343476-41-4 | Acid-PEG5-NHS ester | Broadpharm | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
Acid-PEG5-NHS ester | Broadpharm | 1343476-41-4 | MFCD27952888 | 435.426 | C18H29NO11 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 249969232
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 5 MG
Azide-PEG4-VC-PAB-doxorubicin is a drug-linker conjugate that links the cytotoxic agent doxorubicin to an azide-PEG4-VC-PAB cleavable linker, intended for use in antibody-drug conjugate (ADC) construction and click-chemistry conjugation (CuAAC and SPAAC).
- Contains an azide functional group for click conjugation.
- Compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition reactions.
- Features a cleavable valine-citrulline-p-aminobenzyl (VC-PAB) linker for intracellular release.
- Supplied as an orange to red solid for convenient handling and storage.
- Purity 99.6% and molecular weight 1222.25 g/mol.
- Available in small-mass pack sizes suitable for research-scale ADC synthesis.
eMolecules 1426164-53-5 | Bis-Mal-Lysine-PEG4-TFP ester | Broadpharm | MFCD28385461 | 843.783 | C37H45F4N5O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)C(CCCCNC(=O)CCN2C(=O)C=CC2=O)NC(=O)CCN2C(=O)C=CC2=O)c1F | 100mg | 272383796
Bis-Mal-Lysine-PEG4-TFP ester | Broadpharm | 1426164-53-5 | MFCD28385461 | 843.783 | C37H45F4N5O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCNC(=O)C(CCCCNC(=O)CCN2C(=O)C=CC2=O)NC(=O)CCN2C(=O)C=CC2=O)c1F | 100mg | 272383796
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG24-CH2CH2COOH | 100 g | CAS 2170484-59-8 | MDL MFCD11041159
Fmoc-NH-PEG24-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2170484-59-8
- MDL: MFCD11041159
- InChIKey: NFOMZHGRFWXDGH-UHFFFAOYSA-N
- Molecular Weight: 1368.609
- Molecular Formula: C66H113NO28
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76-pentacosaoxa-4-azanonaheptacontan-79-oic acid
- SMILES: OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)=O
Medchemexpress LLC Mal-PEG4-VA-PBD | 1342820-68-1 | 1294.40 g/mol | C68H79N9O17 | 1 MG
Mal-PEG4-VA-PBD is an agent-linker conjugate for antibody-drug conjugate (ADC) development that incorporates a pyrrolobenzodiazepine (PBD) cytotoxic warhead linked via a maleimide-PEG4-valine-alanine (Mal-PEG4-VA) cleavable linker. It is intended for bioconjugation to antibodies through thiol-reactive maleimide chemistry.
- Agent-linker conjugate for ADC development.
- Pyrrolobenzodiazepine (PBD) cytotoxic payload.
- Maleimide-PEG4-valine-alanine cleavable linker for thiol conjugation.
- Suitable for bioconjugation to antibodies and other thiol-containing biomolecules.
- Supplied in milligram quantities for research use.
eMolecules 51951-05-4 | Ambeed | HO-PEG3-CH2COOH | 250mg | 672523475 | A705669 | 208.21 | C8H16O6
Ambeed | HO-PEG3-CH2COOH | 250mg | 672523475 | A705669 | 51951-05-4 | 208.210 | C8H16O6
Medchemexpress LLC Tco-peg4-vc-pab-mmae | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 1 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugate (ADC) research and click-chemistry applications; it couples a trans-cyclooctene (TCO) reactive handle to a PEG4-spaced valine-citrulline-para-aminobenzyl (Val-Cit-PAB) cleavable linker and the cytotoxic payload MMAE.
- High purity (99.3%).
- Molecular weight 1522.91 g/mol.
- Chemical formula C78H127N11O19.
- CAS number 2758671-45-1.
- Suitable for iEDDA click chemistry with tetrazine reagents.
- Intended for ADC synthesis and conjugation research.
- Store at -20°C and protect from light; in solvent store at -80°C up to 6 months or -20°C up to 1 month.
- Available in small research pack sizes (e.g., 1 MG).
STA PHARMACEUTICAL US LLC Fmoc-N-PEG7-acid | 25 g | CAS 1863885-74-8 | MDL MFCD26142985
Fmoc-N-PEG7-acid is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1863885-74-8
- MDL: MFCD26142985
- InChIKey: QTWMNLIXRWCJSM-UHFFFAOYSA-N
- Molecular Weight: 619.708
- Molecular Formula: C32H45NO11
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25-octaoxa-4-azaoctacosan-28-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)O
Medchemexpress LLC Tos-PEG4-t-butyl ester | 217817-01-1 | 100 MG
Tos-PEG4-t-butyl ester is a PROTAC linker characterized by its PEG composition. It is utilized in the synthesis of various PROTACs, including BI-3663. BI-3663 is a highly selective PTK2/FAK PROTAC that employs cereblon ligands to facilitate E3 ligase hijacking for PTK2 degradation, demonstrating an IC50 of 18 nM for PTK2 inhibition.
- PROTAC linker
- Used in the synthesis of PROTACs
- Specific application in creating highly selective PTK2/FAK PROTACs
- Inhibits PTK2 with an IC50 of 18 nM when used in PROTACs
Medchemexpress LLC Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 99.1% | 473.52 | C25H31NO8 | 5 G
Fmoc-NH-PEG4-CH2COOH is an Fmoc-protected PEG4 linker bearing a terminal carboxylic acid. It is used as a cleavable ADC linker and as a PEG-based PROTAC linker for conjugation and linker synthesis. The compound has molecular formula C25H31NO8 and molecular weight 473.52 and is supplied at high purity for research use.
- Fmoc-protected amine compatible with solid-phase and solution-phase synthesis.
- Terminal carboxylic acid enables standard coupling reactions.
- Peg4 spacer increases solubility and provides linker flexibility.
- High purity suitable for research and conjugation chemistry.
- Available in multiple sizes, including a 5 g package.
Medchemexpress LLC (S,R,S)-AHPC-PEG4-NH2 | 2010159-57-4 | MFCD31657338 | 95.6% | 663.83 | C32H49N5O8S | 25 MG
(S,R,S)-AHPC-PEG4-NH2 is an E3 ligase ligand-linker conjugate that combines a VHL-targeting AHPC ligand with a four-unit PEG linker for use in PROTAC design and targeted protein degradation research. It is supplied as a solid powder for laboratory synthesis and biochemical studies.
- Designed for VHL-mediated targeted protein degradation applications.
- Contains a four-unit polyethylene glycol linker to provide flexibility and solubility.
- White to off-white solid powder form suitable for synthesis workflows.
- CAS number 2010159-57-4 for unambiguous identification.
- Molecular weight 663.83 g·mol-1 and formula C32H49N5O8S.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
![eMolecules 2141976-33-0 | endo-BCN-Peg3-maleimide | Combi-Blocks, Inc.519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2318776.JPG-250.jpg)
eMolecules 2141976-33-0 | endo-BCN-Peg3-maleimide | Combi-Blocks, Inc.519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425
endo-BCN-Peg3-maleimide | Combi-Blocks, Inc. | 2141976-33-0519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425
![eMolecules 2107273-26-5 | N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | Broadpharm1093.790 | C57H89ClN2O16 | 97.000 | [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1\C(=C\C=C\C=C\C2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 298819341](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502464211.JPG-250.jpg)
eMolecules 2107273-26-5 | N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | Broadpharm1093.790 | C57H89ClN2O16 | 97.000 | [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1\C(=C\C=C\C=C\C2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 298819341
N-(m-PEG9)-N'-(PEG5-acid)-Cy5 | Broadpharm | 2107273-26-51093.790 | C57H89ClN2O16 | 97.000 | [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1\C(=C\C=C\C=C\C2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 1mg | 298819341