Protein Modification Reagents
Biotium Insulin(E2-E3), CF647 conjugate, 0.1mg/mL
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have
Cayman Chemical GefItInIb-based PROTAC 3 1mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Creative Pegworks 4-Arm PEG-Amine, MW 20k, 1 g
4-Arm PEG-Amine is a multiarm PEG derivative with amine groups at each terminal of the four arms connected to one pentaerythritol core. The reactive primary amine or NH2 group can rapidly react with activated carboxyl acid such as NHS ester to form stable amide bonds.
Medchemexpress LLC Dbco-peg5-nhs ester | 2144395-59-3 | 95.1% | 693.74 | C36H43N3O11 | 100 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used for copper-free click conjugation of azide-containing molecules to primary amines. It functions as a PEG-based linker for bioconjugation and linker chemistry, and is supplied as an oil with defined purity and solubility properties.
- Enables copper-free click conjugation to azide-containing molecules.
- Reacts with primary amines via NHS ester chemistry.
- Provides a PEG5 spacer to reduce steric hindrance and improve solubility.
- High purity suitable for bioconjugation (HPLC ~95%).
- Soluble in DMSO at 100 mg/mL with ultrasonic or warming aid.
- Store solid at -20°C and prepared solutions at -80°C for long-term storage.
Kyfora Bio Polyethylene glycol 1450
Polyethylene glycol (PEG) is a water-soluble biologically inert polymer that has a number of biological and pharmaceutical applications Specifically PEG1450 can be used as an excipient in pharmaceutical products or as a coating on nanoparticles to prevent opsonization in vivo It can also be used for purification of plasmid DNA The polymer chains are hydroxyl terminated at both ends
Medchemexpress LLC Dbco-peg2-acid | 2304558-25-4 | ≥95.0% | C26H28N2O6 | 100 MG
DBCO-PEG2-acid is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain Azide groups. PROTACs themselves are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker.
- Utilized in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups.
- PROTACs degrade target proteins via the ubiquitin-proteasome system.
eMolecules 2353410-09-8 | CBZ-aminooxy-PEG8-acid | Broadpharm591.651 | C27H45NO13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCONC(=O)OCc1ccccc1 | 500mg | 550804529
CBZ-aminooxy-PEG8-acid | Broadpharm | 2353410-09-8591.651 | C27H45NO13 | 97.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCONC(=O)OCc1ccccc1 | 500mg | 550804529
Avanti Polar Lipids DSPE-PEG(2000) AZIDE 100MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[azido(polyethylene glycol)-2000] (ammonium salt) Powder 100mg
Broadpharm DSPE-PEG-Mannose, MW 2000, 50 mg, PEG Lipid, Solid, Purity 90%, Storage -20°C, Shipping Ambient Temperature
DSPE-PEG-Mannose, MW 2000 is a specialized polyethylene glycol (PEG) lipid, specifically engineered for advanced drug delivery systems, particularly in lipid nanoparticle (LNP) formulations. This innovative conjugate includes a DSPE phospholipid and a mannose sugar residue, facilitating targeted delivery of therapeutics and enhancing the stability of formulations. The unique properties of DSPE allow for micelle formation, essential for lipid nanoparticle construction. Additionally, the PEG component significantly increases water solubility and prolongs circulation time in vivo, making it advantageous for delivering mRNA vaccines and other targeted therapies.
- Facilitates targeted drug delivery systems
- Enhances stability for advanced therapies
- Allows for micelle formation, crucial for lipid nanoparticles
- Increases water solubility and circulation time
- Suitable for targeted liposomal delivery systems
Medchemexpress LLC Poly(lactic-co-glycolic acid)-block-poly(ethylene glycol)-maleimide | 95.0% | PLGA 20 kDa; PEG 5.0 kDa | 10 MG
PLGA-PEG-MAL is a thiol-reactive block copolymer comprised of poly(lactic-co-glycolic acid) and polyethylene glycol terminated with a maleimide group. The product is specified with a ~20 kDa PLGA block and a ~5.0 kDa PEG block (LA:GA 40:60) and is intended for research use in nanoparticle formulation, surface functionalization, and conjugation of thiol-containing ligands.
- Polymeric block copolymer with maleimide functional group for thiol conjugation.
- PLGA block ~20 kDa; PEG block ~5.0 kDa, LA:GA ratio 40:60.
- Suitable for nanoparticle formulation and drug delivery research.
- Soluble in DMSO for formulation and conjugation workflows.
- Reported purity approximately 95.0%.
- Supplied in small research quantities (for example, 10 mg packs).
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 50 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are molecules composed of two different ligands connected by a linker, where one ligand binds to an E3 ubiquitin ligase and the other to a target protein. These molecules leverage the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Composed of two different ligands connected by a linker
- Binds to an E3 ubiquitin ligase and a target protein
- Leverages the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
![eMolecules DNP-PEG3-[1,2,3]triazole-PEG5-amido-Mal | Broadpharm |810.815 | C34H50N8O15 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCn2cc(COCCOCCOCCOCCOCCC(=O)NCCN3C(=O)C=CC3=O)nn2)c(c1)[N+]([O-])=O | 50mg | 550804686](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183610.JPG-250.jpg)
eMolecules DNP-PEG3-[1,2,3]triazole-PEG5-amido-Mal | Broadpharm |810.815 | C34H50N8O15 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCn2cc(COCCOCCOCCOCCOCCC(=O)NCCN3C(=O)C=CC3=O)nn2)c(c1)[N+]([O-])=O | 50mg | 550804686
DNP-PEG3-[1,2,3]triazole-PEG5-amido-Mal | Broadpharm |810.815 | C34H50N8O15 | 98.000 | [O-][N+](=O)c1ccc(NCCOCCOCCOCCn2cc(COCCOCCOCCOCCOCCC(=O)NCCN3C(=O)C=CC3=O)nn2)c(c1)[N+]([O-])=O | 50mg | 550804686
Medchemexpress LLC Azide-PEG-amine (MW 2000) | 95.0% | 100 MG
Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Contains an azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.