Protein Modification Reagents
Medchemexpress LLC Dspe-peg-fitc | 1000788-53-3 | 95.0% | 10 MG
DSPE-PEG-FITC (MW 1000) is a fluorescein-labeled PEGylated phospholipid supplied as a powder. It functions as a fluorescent amphiphile that incorporates into lipid bilayers or forms micelles for labeling liposomes, nanoparticles, and membranes in fluorescence microscopy, flow cytometry, and tracking applications. Manufacturer documentation provides purity, storage, and handling details.
Cayman Chemical VH 032 LInker 6 25mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting Bcl-xL in senescent cells
eMolecules Propargyl-PEG4-alcohol | 208827-90-1 | MFCD13189984 | 1g
Broadpharm | Propargyl-PEG4-alcohol | 1g | 229582798 | BP-21724 | 98.000 | 208827-90-1 | MFCD13189984 | 188.223 | C9H16O4
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Medchemexpress LLC m-PEG-DMG | 1019000-64-6 | 98.0% | 2000 (average) | 50 MG
m-PEG-DMG (MW 2000) is a PEGylated lipid supplied as a powder with an average PEG molecular weight of 2000. It is intended for incorporation into liposomes and lipid nanoparticles for formulation and drug delivery research, providing a PEG surface modification to improve colloidal stability and in vivo circulation.
- PEGylated lipid suitable for liposome and lipid nanoparticle formulation.
- Average molecular weight about 2000 for consistent PEG chain length.
- Enhances particle stability and circulation time in biological systems.
- Supplied as a powder compatible with solvent-based formulation workflows.
- Stable under recommended frozen storage for extended shelf life.
Medchemexpress LLC m-PEG-DSPE sodium | 95.0% | 3000 Da (average) | (C2H4O)nC44H88NO9P | 500 MG
m-PEG-DSPE sodium (MW 3000) is a PEGylated phospholipid sodium salt supplied as a solid. It is commonly used to produce long-circulating liposomes and lipid nanoparticles to improve colloidal stability, steric protection, and tissue distribution of poorly soluble drugs. Manufacturer documentation includes a datasheet, certificate of analysis, and safety data sheet.
- PEGylated phospholipid with average molecular weight ~3000 Da.
- Improves nanoparticle colloidal stability and steric hindrance.
- Prolongs circulation time in vivo.
- Compatible with liposome and lipid nanoparticle formulations.
- Available as a solid in 500 MG pack sizes.
- Typical purity approximately 95.0%.
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 | C22H35NO8 | 10 MG
endo-BCN-PEG4-acid is a cleavable four-unit polyethylene glycol (PEG) linker containing a bicyclononyne (BCN) group that enables strain-promoted alkyne-azide cycloaddition (SPAAC). It is used as a copper-free click chemistry reagent for bioconjugation, including antibody-drug conjugate and PROTAC linker synthesis.
- Cleavable 4-unit PEG linker facilitating conjugation.
- BCN moiety enables copper-free SPAAC with azide groups.
- Molecular weight 441.52 and formula C22H35NO8.
- CAS number 1881221-47-1; high purity for research use.
- Storage recommendations include low-temperature conditions for long-term stability.
- Typical applications: ADC linker chemistry, bioconjugation, and PROTAC synthesis.
Medchemexpress LLC Diketone-PEG4-PFP ester | 2353409-84-2 | ≥97.0% | 647.58 | 25 MG
Diketone-PEG4-PFP ester is a PROTAC linker, specifically a PEG-based PROTAC linker, designed for use in the synthesis of PROTACs. PROTACs themselves are compounds that contain two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein intended for degradation. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- Diketone-PEG4-PFP ester is a PEG-based PROTAC linker.
- It is used in the synthesis of PROTACs.
- PROTACs utilize the ubiquitin-proteasome system for selective degradation of target proteins.
Sigma Aldrich Fine Chemicals Biosciences TCO PEG4 succinimidyl este25MG
TCO PEG4 succinimidyl este25MG
Medchemexpress LLC N-Mal-N-bis(PEG4-NH-Boc) | 2128735-27-1 | 97.0% | C37H66N4O15 | 100 MG
N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based PROTAC linker, intended for research use only. This compound can be utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Suitable for PROTAC synthesis
- Supports the study of PROTACs that selectively degrade target proteins
- For research use only
- Exhibits in vitro biological activity
Cayman Chemical mal-PEG2-AZD 5mg
A bioconjugation linker; has been used in the development of protein- and peptidomimetic-antibody conjugates
Medchemexpress LLC Bromoacetamido-PEG4-acid | 1807518-67-7 | MFCD28950779 | 96.8% | 386.24 g·mol⁻¹ | C13H24BrNO7 | 500 MG
Bromoacetamido-PEG4-acid is a 4-unit polyethylene glycol (PEG4) linker bearing a bromoacetamido functional group. It is used as a cleavable spacer and reactive handle in the synthesis of PROTACs and antibody-drug conjugates (ADCs), providing aqueous solubility and sites for nucleophilic conjugation.
- 4-unit PEG spacer improves solubility and flexibility
- Bromoacetamido reactive group enables nucleophilic substitution conjugation
- Molecular weight 386.24 g·mol⁻¹
- CAS number 1807518-67-7
- Purity 96.8% (as supplied)
- Typical package size 500 MG
Medchemexpress LLC m-PEG4-MS | 130955-37-2 | ≥95.0% | 286.34 | C10H22O7S | 250 MG
m-PEG4-MS is a PEG-based linker used in the synthesis of PROTAC molecules and as a cleavable linker in antibody-drug conjugates (ADCs).
- PEG-based linker for PROTACs and ADCs.
- CAS number: 130955-37-2.
- Purity: ≥95.0%.
- Molecular formula: C10H22O7S.
- Molecular weight: 286.34 g/mol.
- Package size: 250 mg.
Medchemexpress LLC DBCO-PEG5-NHS ester | 2144395-59-3 | MFCD22380747 | 95.0% | 693.74 | C36H43N3O11 | 10 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used as a bioconjugation linker. It couples to primary amines via the NHS ester and enables copper-free, strain-promoted azide-alkyne cycloaddition through the DBCO moiety, making it suitable for linker synthesis and click-based conjugations in research applications.
- Reacts efficiently with primary amines via the NHS ester.
- Enables copper-free click chemistry using DBCO for strain-promoted azide-alkyne cycloaddition.
- Useful for antibody-drug conjugate and PROTAC linker assembly.
- Supplied as a colorless to light yellow oil with high purity (~95.0%).
- Available in small research quantities suitable for synthesis and labeling.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 5 MG
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker bearing amino and azide functional groups, designed for use in antibody-drug conjugate synthesis and bioconjugation via click chemistry.
- Cleavable 11-unit PEG linker useful for ADC construction.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Amino terminus enables conjugation or further functionalization.
- Improves solubility and flexibility between linked molecules.
- Available in small research quantities for conjugation workflows.
eMolecules N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | 2226235-96-5 | | 10mg
Broadpharm | N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | 10mg | 298819354 | BP-23006 | 97.000 | 2226235-96-5 | | 724.340 | C39H54ClN5O6
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