Protein Modification Reagents
Medchemexpress LLC PROTAC EGFR degrader 11 | 3034244-71-5 | 99.2% | 991.61 | 1 MG
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. It binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
- PROTAC degrader for epidermal growth factor receptor (EGFR).
- DC50 <100 nM.
- Binds CRBN-DDB1 with a Ki of 36 nM.
- Degrades EGFR, focal adhesion kinase (FAK), and RSK1.
- Inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
Medchemexpress LLC Protac Axl degrader 2 | 00-00-0 | 98.0% | 713.79 g/mol | C38H39N11O4 | 5 MG
PROTAC Axl Degrader 2 is a proteolysis targeting chimera designed to induce selective degradation of the Axl receptor tyrosine kinase for research applications. It is intended for in vitro studies of Axl biology and PROTAC-mediated protein degradation.
- Proteolysis targeting chimera (PROTAC) that induces selective degradation of the Axl receptor.
- Targets TAM family receptor tyrosine kinases via a PROTAC mechanism.
- Molecular formula C38H39N11O4 and molecular weight 713.79 g/mol.
- Purity approximately 98.0% as supplied.
- Recommended storage: protect from light and store under nitrogen; in solvent, -80°C for long-term, -20°C short-term.
- For research use only; not validated for clinical or therapeutic use.
Medchemexpress LLC PROTAC EZH2 Degrader-1 | 2641601-67-2 | 99.4% | 942.15 | 25 MG
PROTAC EZH2 Degrader-1 (Compound 150d) is a potent PROTAC EZH2 Degrader that inhibits EZH2 methyltransferase activity with an IC50 of 2.7 nM. EZH2 is critical in many tumorigenesis and development processes.
- Potently inhibits EZH2 methyltransferase activity (IC50: 2.7 nM).
- Demonstrates anti-proliferative activity against human EOL1, MV4-11, Pfeiffer, RS4-11, and WSUDLCL2 cells.
- Inhibits cell viability in H128-LM, H128-BPM, H128 wildtype, and H128-Mut cells.
- Enhances sensitivity of H128-LM cells to Carboplatin, VP16, and VM26.
- Exhibits antitumor activity in H128-LM xenograft mouse models, prolonging survival when combined with Carboplatin, VP16, or VM26.
Medchemexpress LLC Benzoic acid, 2-[[(18S,21S,22R)-22-amino-21-hydroxy-18-(2-methylpropyl)-... | 1351169-27-1 | 97.9% | 917.14 g/mol | C51H72N4O11 | 5 MG
PROTAC RAR Degrader-1 is a proteolysis-targeting chimera designed to induce degradation of retinoic acid receptor family members by recruiting IAP E3 ligases. It is supplied as a solid research compound characterized by formula C51H72N4O11 and a molecular weight of 917.14 g/mol, intended for cellular studies of RAR/RXR biology.
- Induces degradation of retinoic acid receptors.
- Targets cIAP1 and RXRα.
- Molecular formula C51H72N4O11; molecular weight 917.14 g/mol.
- Purity 97.9%.
- Appearance: solid.
- Solubility: DMSO ≥ 80 mg/mL (87.23 mM).
- Storage: -20°C under nitrogen; in solution store at -80°C up to 6 months or -20°C up to 1 month.
Sigma Aldrich Fine Chemicals Biosciences GUANIDINE HYDROCHLORIDE 2KG
NC3886659 GUANIDINE HYDROCHLORIDE 2KG
AdipoGen Guanidine hydrochloride
Chemical. CAS 50-01-1. Formula CH5N3 . HCl. MW 59.07 . 36.46. Guanidine hydrochloride is a powerful, chaotropic agent which is widely used for purification of proteins and nucleic acids. It is useful for denaturation and refolding of proteins as well as in the recovery of periplasmic proteins. At higher concentrations, this strong denaturant has been reported to solubilize denatured insoluble proteins such as inclusion bodies and to increase the solubility of hydrophobic molecules. When utilized at lower concentrations, it is useful in prompting the refolding of denatured proteins. Guanidine hydrochloride is also been reported to allow return of enzymatic activity in protocols using it as a first step. Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Cayman Chemical PROTAC CRBN Degrader-1 5mg
A PROTAC that drives CRBN degradation (DC50 = 200 nM in HeLa cells)
Medchemexpress LLC HDAC6 degrader-1 | 2439058-23-6 | 95.7% | 795.84 | C40H45N9O9 | 5 MG
HDAC6 degrader-1 is a proteolysis-targeting chimera (PROTAC) designed to selectively induce degradation of histone deacetylase 6 (HDAC6) in cell-based studies. It links an HDAC6-binding ligand to an E3 ligase recruiter to promote ubiquitination and proteasomal clearance of the target protein, and has been reported to show potent cellular activity.
- Selective degradation of HDAC6 in cells
- Potent cellular activity: DC50 3.8 nM in MM.1S cells
- Research-grade solid with high purity (95.7%)
- Molecular weight 795.84 for assay planning
- Available in small research pack sizes suitable for in vitro studies
- Store sealed, away from moisture; in solvent: -80°C (6 months), -20°C (1 month)