Protein Modification Reagents
Medchemexpress LLC Alkyne-PEG5-SNAP | C27H36N6O7 | 5 MG
Alkyne-PEG5-SNAP is a click chemistry reagent containing an alkyne group, enabling specific and rapid reactions with SNAP-tag fusion proteins for irreversible and covalent labeling. It can also participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- Contains an alkyne group
- Enables conjugation of benzylguanine (BG)
- Reacts specifically and rapidly with SNAP-tag fusion proteins
- Allows for irreversible and covalent labeling of SNAP fusion proteins with additional alkyne functionality
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 50 MG
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker. This degrader incorporates the VH285 based VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
eMolecules 17598-96-8 | PEG-14 | Broadpharm | MFCD20926392 | 590.704 | C26H54O14 | 96.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 250mg | 138794155
PEG-14 | Broadpharm | 17598-96-8 | MFCD20926392 | 590.704 | C26H54O14 | 96.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 250mg | 138794155
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 100 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for click chemistry and bioconjugation, typically employed in the synthesis of antibody-drug conjugates (ADCs) via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Cleavable four-unit PEG linker suitable for ADC and PROTAC synthesis.
- Contains a strained BCN moiety for efficient SPAAC with azide-containing partners.
- High purity for conjugation applications.
- Liquid form, colorless to light yellow, with recommended low-temperature storage.
- Available as a 100 MG pack for laboratory use.
Medchemexpress LLC DBCO-PEG24-acid | 2765066-36-0 | C70H116N2O28 | 5 MG
DBCO-PEG24-acid is a click chemistry reagent and an analog of DBCO-Acid featuring a PEG linker and a DBCO group. The DBCO group is utilized in copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain enhances water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g., EDC or HATU) to form a stable amide bond. This product is reagent grade and intended for research use only.
- Click chemistry reagent
- Analog of DBCO-Acid with PEG linker and DBCO group
- DBCO group for copper-free Click Chemistry reactions
- Strain-promoted high energy DBCO group
- Hydrophilic PEG chain enhances water solubility
- Terminal carboxylic acid reacts with primary amine groups
- Forms stable amide bond with activators (e.g., EDC or HATU)
- Reagent grade
- Intended for research use only
Medchemexpress LLC Azide-PEG-amine (MW 5000) | 95.0% | N₃(CH₂CH₂O)nNH₂ | 50 MG
Azide-PEG-amine (MW 5000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Facilitates protein degradation via PROTACs
- White to off-white solid appearance
- Average molecular weight of 5000
Medchemexpress LLC Alkyne-SNAP | 1104822-07-2 | C18H18N6O2 | 5 MG
Alkyne-SNAP is an Alkyne-conjugated benzylguanine. The benzylguanine moiety reacts with the SNAP-tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional alkyne functionality for further click chemistry conjugation.
- Alkyne-conjugated benzylguanine
- Reacts with SNAP-tag
- Enables irreversible and covalent labeling of SNAP fusion proteins
- Provides alkyne functionality for click chemistry conjugation
- Suitable for labeling and fluorescence imaging
- Useful in antibody-drug conjugate (ADC) related applications
STA PHARMACEUTICAL US LLC FmocNH-PEG8-CH2CH2COOH | 5 g | CAS 756526-02-0 | MDL MFCD11041143
FmocNH-PEG8-CH2CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 756526-02-0
- MDL: MFCD11041143
- InChIKey: VYXGUCLTEWCVRY-UHFFFAOYSA-N
- Molecular Weight: 663.761
- Molecular Formula: C34H49NO12
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid
- SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
STA PHARMACEUTICAL US LLC Fmoc-NH-PEG8-CH2COOH | 5 g | CAS 868594-52-9 | MDL MFCD27635163
Fmoc-NH-PEG8-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 5 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 868594-52-9
- MDL: MFCD27635163
- InChIKey: JRLUSGRARXJCNA-UHFFFAOYSA-N
- Molecular Weight: 649.734
- Molecular Formula: C33H47NO12
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28-nonaoxa-4-azatriacontan-30-oic acid
- SMILES: O=C(COCCOCCOCCOCCOCCOCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
![eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472886.JPG-250.jpg)
eMolecules endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
endo-BCN-PEG8-amine | Broadpharm |588.739 | C29H52N2O10 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1[C@@H]2CCC#CCC[C@H]12 | 100mg | 795361837
Medchemexpress LLC DSPE-PEG-maleimide (MW 3400) ammonium | 474922-22-0 | >95.0% | 3,400 Da | (C2H4O)nC52H93N3NaO13P | 50 MG
DSPE-PEG-maleimide (MW 3400) ammonium is a phospholipid-polyethylene glycol conjugate bearing a terminal maleimide reactive group. Supplied as the ammonium salt with a nominal PEG molecular weight of 3,400 Da, it is used to introduce thiol-reactive functionality into lipid assemblies for site-specific conjugation and formulation of PEGylated lipid nanoparticles and nanostructured lipid carriers.
- Provides maleimide functionality for thiol-specific conjugation.
- Anchors into lipid bilayers via DSPE for stable incorporation into liposomes and nanoparticles.
- PEG chain (3,400 Da) imparts steric stabilization and extended circulation.
- Compatible with thiol-containing ligands for targeted conjugation.
- Typically supplied at ≥95% purity; store under dry and low-temperature conditions.
eMolecules 1235514-18-7 | t-Boc-Aminooxy-PEG3-amine | Broadpharm | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
t-Boc-Aminooxy-PEG3-amine | Broadpharm | 1235514-18-7 | MFCD24471202 | 308.375 | C13H28N2O6 | 98.000 | CC(C)(C)OC(=O)NOCCOCCOCCOCCN | 500mg | 303671296
![eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1681017.jpg-250.jpg)
eMolecules 642091-68-7 | t-Boc-N-Amido-PEG3-azide | Broadpharm | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417
t-Boc-N-Amido-PEG3-azide | Broadpharm | 642091-68-7 | MFCD22056317 | 318.374 | C13H26N4O5 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 500mg | 112541417
Cayman Chemical GefItInIb-based PROTAC 3 1mg
A PROTAC comprised of gefitinib linked to VHL ligand 1; induces degradation of EGFR containing the activating mutation L858R or an exon 19 deletion (DC50s = 22.3 and 11.7 nM, respectively) but does not induce degradation of wild-type EGFR at ≤10 μM in cell-based assays
Medchemexpress LLC Dde biotin-PEG4-DBCO | 1807512-43-1 | MFCD28505548 | 96.2% | C47H61N5O9S | 10MG
Dde Biotin-PEG4-DBCO is a PEG-based cleavable biotinylation reagent bearing a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC). It is used as a PROTAC linker and a copper-free click chemistry reagent for bioconjugation, affinity capture, and target identification workflows.
- Contains DBCO for copper-free SPAAC reactions.
- Dde-protected biotin enables controlled deprotection and release.
- PEG4 spacer improves solubility and reduces steric hindrance.
- High purity (approx. 96.2%) suitable for bioconjugation.
- Solid form; store powder at -20°C for extended stability.