Protein Modification Reagents

Medchemexpress LLC Azido-PEG6-MS | 352439-38-4 | MFCD34471264 | >95.0% | 385.43 | C13H27N3O8S | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Azido-PEG6-MS is an azide-terminated PEG6 linker used as a click-chemistry reagent and in PROTAC linker synthesis. It provides a short, flexible, hydrophilic spacer with a terminal azide that enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition for attaching small molecules or biomolecules in medicinal chemistry and bioconjugation applications.

• Contains an azide functional group for click chemistry reactions.
• Provides a PEG6 spacer for hydrophilicity and conformational flexibility.
• Suitable for PROTAC linker synthesis and bioconjugation workflows.
• Supplied in small-scale quantities appropriate for research use.
• Compatible with common conjugation conditions, including CuAAC.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC 2,2,3,3-tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol | 134179-40-1 | MFCD25424114 | 97.0% | 308.49 g/mol | C14H32O5Si | 1 G

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

TBDMS-PEG4-OH is a tert-butyldimethylsilyl-protected PEG4 alcohol used as a PEG-based linker for PROTAC synthesis. It provides a short, flexible polyethylene glycol spacer with a protected terminal hydroxyl for downstream functionalization in bifunctional molecules and conjugation chemistry.

• TBDMS-protected terminal hydroxyl for selective deprotection.
• PEG4 spacer provides flexibility and improved solubility.
• High purity (97.0%) suitable for research applications.
• Soluble in DMSO for common laboratory workflows.
• Available in small pack sizes appropriate for discovery-stage synthesis.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC DSPE-PEG-folate | 95.7% | 5,000 Da (average) | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

DSPE-PEG-Folate is a pegylated lipid conjugate consisting of a DSPE lipid anchor linked to a polyethylene glycol chain terminated with folic acid (average MW 5,000 Da). It is designed to incorporate into lipid bilayers or micelles and provide folate-receptor targeting for nanoparticle and drug-delivery research. Supplied for laboratory formulation and functionalization.

• Provides folate-mediated targeting to folate receptor-expressing cells.
• Incorporates into lipid bilayers and micelles for nanoparticle functionalization.
• Average molecular weight of 5,000 Da for steric stabilization and circulation.
• High purity suitable for research applications.
• Available in small research pack sizes for formulation trials.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ Broadpharm / N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) / 1mg / 718091677 / BP-28218 / 98.000 / / [null] / 3330.135 / C171H266N24O42

Broadpharm / N-DBCO-N-bis(PEG2-amide-PEG4-Val-cit-PAB-MMAE) / 1mg / 718091677 / BP-28218 / 98.000 / / [null] / 3330.135 / C171H266N24O42

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ DBCO-PEG8-PFP ester | Broadpharm |894.886 | C44H51F5N2O12 | 0.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 50mg | 563055179

DBCO-PEG8-PFP ester | Broadpharm |894.886 | C44H51F5N2O12 | 0.000 | Fc1c(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2Cc3ccccc3C#Cc3ccccc23)c(F)c1F | 50mg | 563055179

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC Methyltetrazine-PEG4-acid | 1802907-91-0 | 99.8% | C20H28N4O7 | 25 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Methyltetrazine-PEG4-acid is a solid laboratory chemical primarily used for the manufacture of substances. It has a molecular weight of 436.46 and typically appears as a purple to purplish-red solid.

• Purity: 99.8% (HPLC)
• Molecular formula: C20H28N4O7
• Stable under recommended storage conditions
• Boiling point/range: 647.6±65.0 °C at 760 mmHg
• Relative density: 1.236 g/cm³
• Recommended storage:
  • Powder: -20°C for 3 years; 4°C for 2 years
  • In solvent: -80°C for 6 months; -20°C for 1 month

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC (S,R,S)-AHPC-PEG2-acid | 2172820-09-4 | 98.9% | C30H42N4O8S | 25 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

• PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
• PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ 2093197-93-2 | BDP FL-PEG5-propargyl | Broadpharm | MFCD30723294 | 549.420 | C27H38BF2N3O6 | 97.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCOCC#C)n1[B-]2(F)F | 1mg | 340377011

BDP FL-PEG5-propargyl | Broadpharm | 2093197-93-2 | MFCD30723294 | 549.420 | C27H38BF2N3O6 | 97.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCOCC#C)n1[B-]2(F)F | 1mg | 340377011

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ 604786-74-5 | Biotin-PEG23-amine | Broadpharm | MFCD21363310 | 1299.610 | C58H114N4O25S | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 229582510

Biotin-PEG23-amine | Broadpharm | 604786-74-5 | MFCD21363310 | 1299.610 | C58H114N4O25S | 97.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 229582510

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC MC-VC-PABC-amide-PEG1-CH2-CC-885 | 2722697-82-5 | 99.9% | C55H68ClN11O13 | 1 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

MC-VC-PABC-amide-PEG1-CH2-CC-885 is a neoDegrader-Linker conjugate consisting of the GSPT1 degrader/molecular glue CC-885 and a linker. This compound is utilized in the synthesis of Antibody-Drug Conjugates (ADCs) and Antibody neoDegrader Conjugates (AnDCs), which are designed to specifically degrade intracellular target proteins within target cells. It can be conjugated to various antibodies to form these conjugates.

• Consists of a GSPT1 degrader/molecular glue and a linker.
• Can be conjugated to various antibodies to form conjugates.
• Designed to specifically degrade intracellular target proteins within target cells.
• Utilized in the synthesis of antibody-drug conjugates (ADCs).
• Utilized in the synthesis of antibody neoDegrader conjugates (AnDCs).

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ N-bis(Amine-PEG8)-N-(PEG8-t-butyl ester) | Broadpharm |1288.612 | C59H121N3O26 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCN)CCOCCOCCOCCOCCOCCOCCOCCOCCN | 100mg | 784454967

N-bis(Amine-PEG8)-N-(PEG8-t-butyl ester) | Broadpharm |1288.612 | C59H121N3O26 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCOCCOCCOCCOCCN)CCOCCOCCOCCOCCOCCOCCOCCOCCN | 100mg | 784454967

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Cayman Chemical dPE-PEG 2000 Cynur 1mg

A PEGylated form of DSPE; has been used in the generation of LNPs for the delivery of miRNA in vitro; LNPs containing DSPE-PEG(2000) cyanur, encapsulating let-7a miRNA, and conjugated to ephrin-A1 reduce the proliferation and colony formation and size of NCI H2081, NCI 5380, and A549 cancer cells, as well as reduce migration of NCI 5380 cells in a wound healing assay

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Cayman Chemical STng PROTAC SP23 1mg

A PROTAC that drives STING degradation; degrades STING in THP-1 cells (DC50 = 3.2 µM); decreases cGAMP-induced increases in the levels of IFN-β, IL-6, and CXCL10 in THP-1 cells at 2.5-10 µM; reduces kidney weight, improves kidney function, and increases the survival rate in a mouse model of cisplatin-induced acute kidney injury at 30 and 60 mg/kg

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

eMolecules​ TCO-PEG24-DBCO | Broadpharm |1556.883 | C78H129N3O28 | 92.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 10mg | 672542390

TCO-PEG24-DBCO | Broadpharm |1556.883 | C78H129N3O28 | 92.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCC\C=C\CC1)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 10mg | 672542390

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More

Medchemexpress LLC Alkyne Cholesterol | 1631985-09-5 | C26H40O | 1 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Alkyne Cholesterol is a modified lipid that functions as a click chemistry reagent containing an alkyne group. This terminal alkyne group enables highly specific linking reactions with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. It can be utilized for tracking cellular cholesterol metabolism and localization.

• Functions as a click chemistry reagent
• Contains a terminal alkyne group
• Facilitates specific linking reactions with azide-containing reagents
• Requires a copper-containing catalyst
• Used for tracking cellular cholesterol metabolism
• Used for tracking cellular cholesterol localization

Encompass Procurement Services
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More