Protein Modification Reagents
ILEX LIFE SCIENCES LLC Cellendes 3-D Life PVA-PEG Hydrogel SG Ready-To-Design Kit (1 Kit)
3-D Life is the most flexible system for biomimetic hydrogel design. It uses two polymers that form a hydrogel by covalent crosslinking at ambient temperature. The chemical reaction is non-toxic to cells and occurs rapidly, preventing cell settlement before the gel is formed. 3-D Life PVA-PEG Hydrogel SG Kit provides reagents for setting up slow gelling, cell-compatible hydrogels for 3D cell cultures. Components are mixed at physiological pH 7.2 for optimal cell compatibility. Slow gelation allows enough time to manipulate the solution before onset of gel formation. Peptides (e.g. 3-D Life RGD Peptide, Cat. No. 09-P-001) can be covalently attached to a portion of the SH-reactive groups of SG-PVA to provide a cell-adhesive matrix. One kit allows formation of up to 2 ml hydrogel depending on gel stiffness. Manufactured in Germany by Cellendes GmbH.
Medchemexpress LLC Biotin-PEG2-acid | 1365655-89-5 | MFCD22056305 | ≥97.0% | 403.49 g·mol⁻¹ | C17H29N3O6S | 250 MG
Biotin-PEG2-acid is a biotinylated polyethylene glycol linker with a terminal carboxylic acid, used as a non-cleavable ADC and PROTAC linker for bioconjugation, affinity labeling, and linker synthesis. It is supplied in small laboratory pack sizes for conjugation workflows.
- Biotinylated PEG linker with a terminal carboxylic acid for conjugation.
- Non-cleavable two-unit PEG spacer suited for ADC and PROTAC syntheses.
- High purity (≥97.0%) for reliable conjugation performance.
- Molecular weight 403.49 g·mol⁻¹; formula C17H29N3O6S.
- Available in small-scale quantities such as 250 MG.
- Store protected from light under argon at -20°C; in solvent store at -80°C for long-term.
eMolecules 1393330-40-9 | Propargyl-PEG5-NHS ester | Broadpharm | MFCD22574798 | 401.412 | C18H27NO9 | 98.000 | O=C(CCOCCOCCOCCOCCOCC#C)ON1C(=O)CCC1=O | 100mg | 229582898
Propargyl-PEG5-NHS ester | Broadpharm | 1393330-40-9 | MFCD22574798 | 401.412 | C18H27NO9 | 98.000 | O=C(CCOCCOCCOCCOCCOCC#C)ON1C(=O)CCC1=O | 100mg | 229582898
eMolecules 1924596-31-5 | Mal-amido-PEG8-TFP ester | Broadpharm | MFCD28505514 | 740.699 | C32H44F4N2O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)c1F | 500mg | 279709072
Mal-amido-PEG8-TFP ester | Broadpharm | 1924596-31-5 | MFCD28505514 | 740.699 | C32H44F4N2O13 | 98.000 | Fc1cc(F)c(F)c(OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)c1F | 500mg | 279709072
STA PHARMACEUTICAL US LLC Azide-PEG3-L-alanine-Fmoc | 10 g | CAS 2054345-69-4 | InChIKey YTHKPQSMRZQREU-JOCHJYFZSA-N
Azide-PEG3-L-alanine-Fmoc is a Amino Acid reagent (Subcategory: Azido/Alkynyl AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2054345-69-4
- MDL: No data
- InChIKey: YTHKPQSMRZQREU-JOCHJYFZSA-N
- Molecular Weight: 484.509
- Molecular Formula: C24H28N4O7
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29299090
- Country Of Origin: China
- IUPAC: N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-D-serine
- SMILES: O=C(N[C@H](COCCOCCOCCN=[N+]=[N-])C(O)=O)OCC1C2=C(C=CC=C2)C3=C1C=CC=C3
Medchemexpress LLC Bromoacetamido-PEG2-C2-NHS ester | 1353011-78-5 | 95.0% | C13H19BrN2O7 | 25 MG
Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- Selectively degrades target proteins
eMolecules Bromo-PEG24-t-butyl ester | Broadpharm |1266.355 | C55H109BrO26 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr | 250mg | 452533439
Bromo-PEG24-t-butyl ester | Broadpharm |1266.355 | C55H109BrO26 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr | 250mg | 452533439
Medchemexpress LLC E3 LIGASE LIGANDLINKER2(100MG)
Pomalidomide-PEG4-Ph-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2). Purity: >98.0%.CAS 1818885-63-0
Medchemexpress LLC NHS-PEG2-SS-PEG2-NHS | 96.7% | 580.63 g/mol | C22H32N2O12S2 | 5 MG
NHS-PEG2-SS-PEG2-NHS is a cleavable four-unit polyethylene glycol (PEG) linker with N-hydroxysuccinimide (NHS) ester end groups and a disulfide (SS) cleavable junction, supplied for use in antibody-drug conjugate synthesis and other bioconjugation applications.
- Cleavable disulfide bond enables reductive release of payloads.
- Hydrophilic PEG spacer improves solubility and reduces aggregation.
- NHS ester end groups provide rapid amine coupling to proteins.
- Moderate molecular weight supports spacer function without excessive steric bulk.
- Available in small research sizes suitable for conjugation optimization.
Medchemexpress LLC HY-128716A 100mg Medchemexpress, Pomalidomide-PEG3-C2-NH2 (TFA) CAS: Purity:>98%
Medchemexpress, HY-128716A 100mg Pomalidomide-PEG3-C2-NH2 (TFA) CAS: Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Boc-NH-PEG4-C2-Boc | 2138484-13-4 | 421.53 | 25 MG
Boc-NH-PEG4-C2-Boc is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). These molecules are designed to selectively degrade target proteins by exploiting the intracellular ubiquitin-proteasome system. PROTACs feature two different ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two ligands connected by a linker
- Targets an E3 ubiquitin ligase
- Targets a specific protein
- Exploits the intracellular ubiquitin-proteasome system for selective protein degradation
Medchemexpress LLC M-PEG5-azide | 1202681-04-6 | 50 MG
M-PEG5-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Functions as a PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules
Medchemexpress LLC Mal-PEG36-NHS ester | 95.0% | 1923.18 g/mol | C86H159N3O43 | 5 MG
Mal-PEG36-NHS ester is a polyethylene glycol (PEG)-based bifunctional linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. Supplied for research use, it is designed for bioconjugation and PROTAC synthesis, enabling sequential coupling to thiol and amine groups.
- Maleimide and NHS ester functional groups for thiol and amine coupling.
- PEG spacer (36 units) provides flexibility and solubility.
- Molecular weight 1923.18 g/mol.
- Purity 95.0%.
- Soluble in DMSO at 62.5 mg/mL (requires ultrasonic agitation).
- Storage: pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Intended for research use only.
Medchemexpress LLC m-PEG4-CH2COOH | 16024-66-1 | 99.9% | 1 G
This PEG-based PROTAC linker is used in the synthesis of PROTACs. It is intended for research applications.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Purity of 99.86%
- Molecular formula C11H22O7
- Molecular weight 266.29
- Appears as a colorless to light yellow liquid
- Specific storage conditions for pure form and in solvent
- Soluble in various solvents for in vitro and in vivo studies
- Relevant for cancer and cancer targeted therapy research
Medchemexpress LLC DBCO-PEG4-eosin 5-isothiocyanate | 96.7% | 1228.59 | C50H44Br4N4O11S | 10 MG
DBCO-PEG4-Eosin 5-isothiocyanate is a click-chemistry-enabled fluorescent probe that links a DBCO (dibenzocyclooctyne) reactive group to eosin 5-isothiocyanate via a PEG4 spacer. It is supplied as an orange-red solid for labeling biomolecules using strain-promoted alkyne-azide cycloaddition (SPAAC) and for fluorescence imaging applications.
- Enables copper-free click conjugation via DBCO
- PEG4 spacer improves solubility and reduces steric hindrance
- Eosin 5-isothiocyanate offers red-orange fluorescence for imaging
- High purity suitable for bioconjugation applications
- Supplied in small milligram quantities for research use
- Store sealed, protected from moisture and light; refrigerate for solids