Protein Modification Reagents
Medchemexpress LLC Benzoic acid, 2-[[(18S,21S,22R)-22-amino-21-hydroxy-18-(2-methylpropyl)-... | 1351169-27-1 | 97.9% | 917.14 g/mol | C51H72N4O11 | 5 MG
PROTAC RAR Degrader-1 is a proteolysis-targeting chimera designed to induce degradation of retinoic acid receptor family members by recruiting IAP E3 ligases. It is supplied as a solid research compound characterized by formula C51H72N4O11 and a molecular weight of 917.14 g/mol, intended for cellular studies of RAR/RXR biology.
- Induces degradation of retinoic acid receptors.
- Targets cIAP1 and RXRα.
- Molecular formula C51H72N4O11; molecular weight 917.14 g/mol.
- Purity 97.9%.
- Appearance: solid.
- Solubility: DMSO ≥ 80 mg/mL (87.23 mM).
- Storage: -20°C under nitrogen; in solution store at -80°C up to 6 months or -20°C up to 1 month.
Medchemexpress LLC Cyanine5 alkyne | 1223357-57-0 | 98.2% | C35H42ClN3O | 10MG
Cyanine5 alkyne is a near-infrared fluorescent dye bearing a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (click chemistry). It enables covalent labeling of azide-functionalized biomolecules for fluorescence imaging and detection in biochemical assays.
- Click-reactive terminal alkyne enables CuAAC conjugation.
- Near-infrared excitation and emission for reduced background in imaging.
- High purity suitable for sensitive fluorescence assays.
- Available in multiple milligram sizes for flexible experimental use.
- Stable when stored sealed away from moisture and light.
Medchemexpress LLC Mal-PEG2-oxyamine TFA | 00-00-0 | 96.5% | 358.27 g/mol | C12H17F3N2O7 | 5 MG
Mal-PEG2-oxyamine TFA is a PEG-based PROTAC linker containing a maleimide and an oxyamine (trifluoroacetate salt) joined by a PEG2 spacer. It is designed for orthogonal bioconjugation-maleimide reacts with thiols and oxyamine forms oximes with aldehydes/ketones-making it suitable for assembling PROTACs and other conjugates. The product is supplied as a colorless to light yellow liquid with high purity and good DMSO solubility.
- Enables thiol conjugation via maleimide chemistry.
- Permits oxime ligation through the oxyamine functional group.
- Short PEG2 spacer provides moderate linker flexibility.
- High solubility in DMSO (≈250 mg/mL) for convenient stock solutions.
- High purity (~96.5%) suitable for research synthesis.
- Stable when stored sealed and protected from moisture.
Medchemexpress LLC HyNic-PEG2-DBCO | 2741281-12-7 | >98.0% | 610.72 g/mol | C34H38N6O5 | 5 MG
HyNic-PEG2-DBCO is a bifunctional PEG2 linker combining a hydrazinonicotinamide (HyNic) reactive handle with a dibenzocyclooctyne (DBCO) moiety for orthogonal bioconjugation. Supplied as a solid (5 mg), it is intended for research use in PROTAC synthesis, protein/antibody conjugation, and copper-free click-chemistry workflows.
- Provides orthogonal conjugation: hydrazone formation and copper-free SPAAC.
- Contains HyNic and DBCO reactive groups for selective coupling.
- PEG2 spacer improves solubility and reduces steric hindrance.
- High purity (>98%) suitable for research applications.
- Supplied as a solid powder for straightforward storage and handling.
- Recommended storage refrigerated at 2-8 °C to preserve stability.
Medchemexpress LLC Mal-PEG4-C2-NH2 TFA | 2512227-13-1 | 430.37 | 250 MG
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Targets E3 ubiquitin ligase and target proteins
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Dopamine-PEG-N3 MW 10mg
Dopamine-PEG-N3 (MW 2000) (Dopamine-PEG-Azide (MW 2000)) is a compound composed of dopamine PEG segments and an azide group (-N3) Dopamine-PEG-N3 (MW 2000) can be used as a crosslinker to connect different materials together to build new composite materials and improve the performance of materials Dopamine-PEG-N3 (MW 2000) is a click chemistry reagent It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an alkyne group
eMolecules Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
Tos-PEG5 t-butyl ester | Broadpharm | 581065-94-3 | MFCD22574810 | 476.580 | C22H36O9S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 1g | 137364352
eMolecules Bis-(N,N'-amine-PEG3)-Cy5, TFA salt | 2107273-36-7 | | 5mg
Broadpharm | Bis-(N,N'-amine-PEG3)-Cy5, TFA salt | 5mg | 306709104 | BP-23034 | 95.000 | 2107273-36-7 | | 855.430 | C43H62ClF3N4O8
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eMolecules m-PEG3-(CH2)3-alcohol | 100688-48-0 | MFCD26841942 | 1g
Broadpharm | m-PEG3-(CH2)3-alcohol | 1g | 368397786 | BP-23808 | 98.000 | 100688-48-0 | MFCD26841942 | 178.228 | C8H18O4
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eMolecules N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) | 2055042-62-9 | MFCD30182037 | 500mg
Broadpharm | N-(Amino-PEG3)-N-bis(PEG3-t-butyl ester) | 500mg | 550804310 | BP-23266 | 97.000 | 2055042-62-9 | MFCD30182037 | 712.919 | C34H68N2O13
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