Protein Modification Reagents
(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472885.JPG-250.jpg)
eMolecules DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 50 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its DBCO group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules
eMolecules Mal-amido-PEG23-amine | Broadpharm |1224.440 | C55H105N3O26 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 599128868
Mal-amido-PEG23-amine | Broadpharm |1224.440 | C55H105N3O26 | 98.000 | NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 250mg | 599128868
Medchemexpress LLC Biotin-PEG2-aldehyde | 00-00-0 | 95.0% | 387.5 g/mol | C17H29N3O5S | 5 MG
Biotin-PEG2-aldehyde is a biotinylated PEG linker bearing a terminal aldehyde functional group for bioconjugation and PROTAC synthesis. The short PEG2 spacer increases aqueous solubility and provides a flexible linkage between the biotin tag and attached payloads.
- Terminal aldehyde enables chemoselective conjugation (hydrazone, oxime, reductive amination)
- PEG2 spacer improves aqueous solubility and flexibility
- Biotin tag enables affinity capture with streptavidin-based reagents
- Compatible with PROTAC and probe synthesis workflows
- High purity suitable for research use (95.0%)
- Available in small research-friendly pack sizes
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 25 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs comprise two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, facilitating the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Peg-based protac linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Vh285-peg4-c4-cl | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
VH285-PEG4-C4-Cl is a conjugate of ligands for E3 and 16-atom-length linker. The connector of the linker is a halogen group. It incorporates a VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. It is able to induce 90% degradation of GFP-Halotag at 625 nM and binds to VHL with an IC50 of 0.54 μM.
- Functions as a conjugate of ligands for E3 and a 16-atom-length linker.
- Incorporates a VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
- Induces nearly complete knockdown of HaloTag7-ERK1 and HaloTag7-MEK1 at 500 nM.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204110.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.
- Provides a noncleavable 2-unit PEG spacer for conjugation
- NHS ester activated for efficient coupling to primary amines
- Aldehyde-phenyl functional group for orthogonal conjugation chemistry
- High purity suitable for research applications
- Available in multiple pack sizes and formats, including 100 MG
Medchemexpress LLC DBCO-PEG5-NHS ester | 2144395-59-3 | MFCD22380747 | 95.0% | 693.74 g/mol | C36H43N3O11 | 5 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used for copper-free click chemistry and amine-directed coupling in bioconjugation. It combines a strained dibenzocyclooctyne (DBCO) for strain-promoted alkyne-azide cycloaddition (SPAAC) with an NHS ester reactive toward primary amines, making it suitable as an ADC or PROTAC linker and in general lab bioconjugation workflows.
- Contains a DBCO strained alkyne for copper-free click chemistry.
- Contains an NHS ester for efficient coupling to primary amines.
- PEG5 spacer provides hydrophilicity and flexible linkage.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied as a solid with reported purity of approximately 95% and molecular weight ~693.7 g/mol.
Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG
HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize two distinct ligands connected by a linker
- Selectively degrades target proteins through the ubiquitin-proteasome system
Cayman Chemical BIOnT PROTAC Fragmnt lbrar 5mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 1 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Medchemexpress LLC Dspe-peg-oh | 99.89% | 100 MG
DSPE-PEG-OH (MW 2000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail allows for the encapsulation and aggregation of other hydrophobic drugs, and its hydroxyl terminus is suitable for further reactions. DSPE-PEG-OH (MW 2000) can be used to prepare liposomes or lipid nanoparticles.
- Hydroxyl-terminated PEGylated phospholipid.
- Hydrophobic tail enables encapsulation and aggregation of other hydrophobic drugs.
- Hydroxyl terminus suitable for further reactions.
- Can be used to prepare liposomes or lipid nanoparticles.
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 250 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an Alkyne group that enables it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves are designed with two distinct ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other targets the protein of interest, utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.73% | C16H29NO6 | 500 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is a click chemistry reagent containing an Alkyne group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have Azide groups. PROTACs themselves consist of two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein, and they degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Degrades target proteins by exploiting the intracellular ubiquitin-proteasome system
![eMolecules 2226235-96-5 | N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | Broadpharm724.340 | C39H54ClN5O6 | 97.000 | [Cl-].CC1(C)\C(=C/C=C/C=C/C2=[N+](CCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)N(CCOCCOCCO)c2ccccc12 | 10mg | 298819354](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203363.JPG-250.jpg)
eMolecules 2226235-96-5 | N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | Broadpharm724.340 | C39H54ClN5O6 | 97.000 | [Cl-].CC1(C)\C(=C/C=C/C=C/C2=[N+](CCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)N(CCOCCOCCO)c2ccccc12 | 10mg | 298819354
N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 | Broadpharm | 2226235-96-5724.340 | C39H54ClN5O6 | 97.000 | [Cl-].CC1(C)\C(=C/C=C/C=C/C2=[N+](CCOCCOCCOCCN=[N+]=[N-])c3ccccc3C2(C)C)N(CCOCCOCCO)c2ccccc12 | 10mg | 298819354
eMolecules 106492-60-8 | Aminooxy-PEG4-alcohol | Broadpharm | MFCD30828691 | 209.242 | C8H19NO5 | 98.000 | NOCCOCCOCCOCCO | 500mg | 349512554
Aminooxy-PEG4-alcohol | Broadpharm | 106492-60-8 | MFCD30828691 | 209.242 | C8H19NO5 | 98.000 | NOCCOCCOCCOCCO | 500mg | 349512554