Cytokines and Receptors Reagents and Kits
Raybiotech Inc G-Series Rat Acute Kidney Injury Antibody Array 1 Kit.
Detects 7 rat Cytokines. Suitable for all liquid sample types. 4 sample kit. Semi-Quantitative, Sandwich-based, Glass Slide Antibody Array Screen and compare protein expression levels with high specificity and sensitivity (pg/ml levels). The glass slide array allows for high throughput and low sample consumption; as little as 10 µl of original sample required per array. Proteins detected: TIM-1 (KIM-1), FABP1, MCP-1 (CCL2), Cystatin C, Lipocalin-2 (NGAL), TIMP-1, VEGF-A
Genscript Corporation Eotaxin/CCL11, Human
CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.
Genscript Corporation IL-6, Mouse
Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, and nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction and released into the blood stream to help break down fats and improve insulin resistance.
Genscript Corporation Eotaxin/CCL11, Mouse
CCL11 is a potent eosinophil chemoattractant that was originally purified from bronchoalveolar lavage fluid of guinea pigs sensitized by aerosol challenge with ovalbumin. Human CCL11 cDNA encodes a 97 amino acid residue precursor protein from which the aminoterminal 23 amino acid residues are cleaved to generate the 74 amino acid residue mature human CCL11. At the protein sequence level, mature human CCL11 is approximately 60% identical to mature mouse and guinea pig CCL11. Human CCL11 is chemotactic for eosinophils, but not mononuclear cells or neutrophils. The CC chemokine receptor 3 (CCR3) has now been identified to be a specific human CCL11 receptor. CCR3 has also been shown to serve as a cofactor for a restricted subset of primary HIV viruses and binding of CCL11 to CCR3 inhibited infection by the HIV isolates.
STEMCELL Technologies Mouse Recombinant IL-19, Size: 50 µg
Interleukin 19 (IL-19) is a member of the IL-10 cytokine family and is produced by keratinocytes, B cells, and monocytes (Romer et al.; Wolk et al.). Expression of IL-19 can be induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS; Gallagher et al.). IL-19 is considered to be a proinflammatory cytokine, as it upregulates IL-6 and tumor necrosis factor alpha (TNF-α; Liao et al. 2002). IL-19 binds the IL-20 receptor complex (IL-20R) which comprises IL-20R alpha and IL-20R beta to activate the STAT3 pathway (Dumoutier et al.). IL-19 also induces T-helper cell differentiation towards a Th2 response, resulting in the production of IL-10 and additional IL-19 (Liao et al. 2002; Liao et al. 2004). IL-19 has been implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.
MilliporeSigma IMMUNOLOGY MULTIPLEX ASSAY
MILLIPLEX MAP Human Cytokine/Chemokine/Growth Factor Panel A 48 Plex Premixed Magnetic Bead Panel - Immunology Multiplex Assay
STEMCELL Technologies Mouse Recombinant IL-11, Size: 1000 µg
Use interleukin 11 (IL-11) together with IL-3, IL-6, and stem cell factor to induce the expansion and proliferation of colony-forming cells in vitro (Peters et al. Blood, 1996). In combination with IL-3, IL-11 significantly enhances the growth of megakaryocytic colonies in vitro, suggesting its role in augmenting mouse megakaryopoiesis (Yonemura et al. Exp Hematol, 1992). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. Expressed in a wide range of normal adult mouse tissues, IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs (Cameron et al. Cytokine Growth Factor Rev, 2015). Mouse recombinant IL-11 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 250 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Adipogenic inhibitory factor, AGIF, Interleukin-11, Oprelvekin.
STEMCELL Technologies Mouse Recombinant IL-1 alpha, Size: 1000 µg
Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes have high levels of intracellular IL-1α precursor, which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al.; Cohen et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
STEMCELL Technologies Human Recombinant IL-7, Size: 1000 µg
Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
Meso Scale Discovery U-PLEX Proinflam Combo 1, multiplex immunoassay, 5 plate size, 2 plates provided, 96-well, detection limits sub- to low pg/mL, sample types: serum, plasma, cell culture supernatant
The U-PLEX Proinflam Combo 1 (NHP) is a multiplex immunoassay designed for measuring nine key proinflammatory biomarkers in non-human primate samples. Utilizing advanced U-PLEX technology with electrochemiluminescence detection, this kit allows for precise cytokine and chemokine analysis across various sample types. It offers low detection limits and a broad dynamic range, making it an efficient solution for researchers. The kit includes two plates, enabling separation of incompatible assays, ensuring accurate performance for each biomarker.
- Assay type: Multiplex immunoassay
- Detection limits: sub- to low pg/mL range
- Number of plates: 2
- Plate type: 96-well
- Compatible sample types: Serum, plasma, cell culture supernatant
- Research use only: true
- Storage condition: Multi-component