Cytokines and Receptors Reagents and Kits
American Research Products Inc Rat C X C motif chemokine 3 C
Rat C-X-C motif chemokine 3 (CXCL3) ELISA kit from CUSABIO Detection Range 15 6 pg/ml - 1000 pg/ml Sensitivity 3 9 pg/ml Sample serum plasma tissue homogenates Method Sandwich
Revvity Health Sciences Inc HTRF Human CCL5 Detection Kit, 500 Assay Points
HTRF Human CCL5 Detection Kit, 500 Assay Points
STEMCELL Technologies Human Recombinant IL-13, Size: 1000 µg
Use interleukin 13 (IL-13) to promote B cell proliferation, induce class switching to IgG4 and IgE, and recruit and activate IgE-producing B cells (Hershey. J Allergy Clin Immunol, 2003). IL-13 is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) (Pulendran & Artis. Science, 2012). It binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2 (Wynn. Annu Rev Immunol, 2003) and is expressed on a wide range of cells.. Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. In vivo, IL-13 has a role in resistance to extracellular helminth parasites, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis (Wynn. Nat Rev Immunol, 2015). Human recombinant IL-13 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 5 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Interleukin-13, NC30.
STEMCELL Technologies Human Recombinant IL-7, Size: 1000 µg
Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
![Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 250 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-Z11402-0.25.JPG-250.jpg)
Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 250 Milligrams
Naturally occurring cytokinin riboside. Main effects in tissue culture systems include control of shoot growth and formation, cell division and inhibition of leaf senescence. Chromatographically purified and recrystallized. Plant cell culture tested.
Mixed isomers: trans-isomer 97%, cis-isomer >2%.
STEMCELL Technologies Human Recombinant IL-1 beta, Size: 1000 µg
Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-κB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with an antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner.
STEMCELL Technologies Human Recombinant IL-9, Size: 1000 µg
Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld et al.). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops & Renauld; Fontaine et al.). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh et al.; Goswami & Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine et al.). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan et al.).
![Research Products International Corp Cellulase [Onozuka R-10], 5 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-C32200-5.02.JPG-250.jpg)
Research Products International Corp Cellulase [Onozuka R-10], 5 Grams
From Trichadema Viride. Enzyme mixture often used in combination with Macerozyme R-10 for isolation of protoplasts. One unit of Cellulase will liberate 1.0 µmole of glucose from carboxymethyl cellulose. Optimum pH range: 4-5°
Ingredients:
Pectinase: 0.4 U/mg
Hemicellulase: 1.0 U/mg
alpha-Amylase: 0.6 U/mg
Protease: 0.01 U/mg
![Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 50 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-Z11402-0.05.JPG-250.jpg)
Research Products International Corp Zeatin Riboside [9-(B-D-Ribofuranosyl)-Trans-Zeatin], 50 Milligrams
Naturally occurring cytokinin riboside. Main effects in tissue culture systems include control of shoot growth and formation, cell division and inhibition of leaf senescence. Chromatographically purified and recrystallized. Plant cell culture tested.
Mixed isomers: trans-isomer 97%, cis-isomer >2%.
STEMCELL Technologies Human Recombinant IL-1 beta, ACF, Size: 100 µg
Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
STEMCELL Technologies Mouse Recombinant IL-19, Size: 50 µg
Interleukin 19 (IL-19) is a member of the IL-10 cytokine family and is produced by keratinocytes, B cells, and monocytes (Romer et al.; Wolk et al.). Expression of IL-19 can be induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS; Gallagher et al.). IL-19 is considered to be a proinflammatory cytokine, as it upregulates IL-6 and tumor necrosis factor alpha (TNF-α; Liao et al. 2002). IL-19 binds the IL-20 receptor complex (IL-20R) which comprises IL-20R alpha and IL-20R beta to activate the STAT3 pathway (Dumoutier et al.). IL-19 also induces T-helper cell differentiation towards a Th2 response, resulting in the production of IL-10 and additional IL-19 (Liao et al. 2002; Liao et al. 2004). IL-19 has been implicated in aging, vascular disease, Type I diabetes, and rheumatoid arthritis.
STEMCELL Technologies Human Recombinant IL-1 alpha, Size: 1000 µg
Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes, have high levels of intracellular IL-1α precursor. The precursor is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Cohen et al.; Rider et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). Studies in mice show that IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
STEMCELL Technologies Mouse Recombinant IL-6, Size: 1000 µg
Modulate a variety of biological activities in immune regulation, hematopoiesis, and oncogenesis with interleukin 6 (IL-6). IL-6 is a pleiotropic growth factor that stimulates the proliferation of B cells, T cells, and hybridoma cells in combination with other factors (Tanaka et al. Cold Spring Harb Perspect Biol, 2014). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system also activates the JAK/STAT signaling pathway (Mihara et al. Clin Sci, 2012). Mouse recombinant IL-6 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 50 pg/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: B cell differentiation factor, BSF-2, IFN-β2, Interleukin-6.
![Research Products International Corp Zeatin, Trans Isomer [6-(4-Hydroxy-3-methylbut-2-enylamino)purine)], 250 Milligrams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-Z11400-0.25.JPG-250.jpg)
Research Products International Corp Zeatin, Trans Isomer [6-(4-Hydroxy-3-methylbut-2-enylamino)purine)], 250 Milligrams
Naturally occurring cytokinin growth regulator. Promotes cell division and also influences other steps of the cell cycle. High concentrations produce advantitious shoot formation. Other uses include prevention of leaf senescence, reversal of toxin affects on shoots and inhibiting excessive root formation. Off white to yellow crystals. Plant cell culture tested.
STEMCELL Technologies Mouse Recombinant IL-33, Size: 1000 µg
Interleukin 33 (IL-33) is a pro-inflammatory cytokine from the IL-1 family. It binds to the ST2 receptor and activates NF-kB and MAPK pathways. IL-33 is expressed by epithelial cells, smooth muscle cells, and fibroblasts in various tissues and organs, as well as resting basophils, mast cells, eosinophils, natural helper cells, group 2 innate lymphoid cells, dendritic cells, and activated macrophages (Schmitz et al.; Yasuda et al.). It contributes to allergic inflammation by stimulating production of the cytokines IL-4, IL-5, and IL-13 in Th2 cells, and stimulates host defense against microbial and viral infections (Liew; Yasuda et al.). In the central nervous system, IL-33 is produced by endothelial cells and astrocytes. It induces proliferation of microglia and mediates production of pro-inflammatory cytokines (Yasuoka et al.).