General Cell Based Assays
Eurofins Discoverx PathHunter Human TORC3 (CRTC3) Nuclear Translocation Cell-Based Assay Kit (U2OS)
The PathHunter Human TORC3 (CRTC3) Stable Cell Line Nuclear Translocation Assay (U2OS) contains a stable clonal cell line used to measure CRTC/CREB pathway activation via nuclear translocation of TORC3. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human Apelin (APJ Receptor) Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human Apelin (APJ Receptor) Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure AGTRL1 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress c-Ret-GFRα2 Functional Assay, 2-Plate Kit. (93-0816E3CP16M)
The PathHunter eXpress c-Ret-GFRα2 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα2 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα2 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the cynomolgus version of the protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical HS MInral OIl asy Reagent 15mL
A kainate receptor agonist induces currents in Xenopus oocytes expressing homomeric GluR5 or GluR2 subunit-containing receptors (EC50s 0.16 and 0.23 UM respectively) induces desensitization in HEK293 cells expressing homomeric GluR6 subunit-containing kainate receptors at 0.03-0.3 UM selectively binds to the kainate receptor (IC50 ~0.035 UM) over the AMPA and NMDA receptors (IC50s >100 and 7 UM respectively) but does bind to EAAT2 (Kb 3.4 UM) and inhibits glutamate transport reduces hind paw withdrawal frequency and increases withdrawal latency to mechanical and thermal stimuli in a rat model of capsaicin-induced hyperalgesia at 10 50 and 100 mg/kg
Eurofins Discoverx PathHunter eXpress EGFR/ErbB2 Dimerization Assay, 2-Plate Kit. (93-1051E3CP14M)
The PathHunter EGFR/ErbB2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. EGF) induced dimerization of EGFR/ErbB2 receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/ErbB2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Bioss KD-Validated Superoxide Dismut
Superoxide Dismutase 2 Primary Antibody Unconjugated Public Immunogen Range 251-314/428 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
Meso Scale Discovery U-PLEX Mouse IL-13 ASY 25 PL
The Meso Scale Discovery U-PLEX Mouse IL-13 Assay Kit is a multiplex immunoassay that allows simultaneous measurement of mouse interleukin 13 (IL-13) in serum plasma and cell culture supernatants This assay uses electrochemiluminescence (ECL) detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision The kit includes a plate coated with capture antibodies detection antibodies labeled with an ECL compound calibrators controls 10X diluent read buffer wash buffer and adhesive plate seals The assay has a typical sensitivity of 0 3 pg/mL and an upper limit of quantification of 10 000 pg/mL for mouse IL-13
Meso Scale Discovery U-PLEX Human TNF-B ASY
The Meso Scale Discovery U-PLEX Human TNF-beta Assay Kit is a multiplex immunoassay that measures TNF-beta levels in human serum plasma and cell culture supernatants It uses electrochemiluminescence detection technology and provides high sensitivity broad dynamic range and requires low sample volume The assay has high specificity and low cross-reactivity It includes a 96-well plate coated with capture antibodies detection antibodies labeled with electrochemiluminescent tags calibrators and buffer The kit allows simultaneous measurement of TNF-beta and other biomarkers It can be used for biomarker discovery lead optimization and diagnostics
Cytek Biosciences Inc Cell Cycle Kit Amnis
Product Name: Muse Cell Cycle Kit
Cytek Catalog Number: MCH100106
Product Class: Guava Muse Reagent
Type: Muse
Size: 100 Tests
Eurofins Discoverx PathHunter Mouse MDC (CCR4) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse MDC (CCR4) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mCCR4 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
ACROBiosystems Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human, 10000 tests
Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human
Eurofins Discoverx cAMP Hunter eXpress RXFP3 (SALPR) CHO-K1 GPCR Assay, 2-Plate Kit. (95-0102E2CP2M)
The cAMP Hunter RXFP3 (SALPR) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. relaxin-3) based activation of RXFP3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type RXFP3, a naturally Gi/Go coupled GPCR. Upon activation of RXFP3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human PPAR delta Nuclear Receptor Protein Interaction Cell-Based Assay Kit (CHO-K1)
The PathHunter Human PPAR delta Nuclear Receptor Stable Cell Line Protein Interaction Assay (CHO-K1) contains a stable clonal cell line used to measure activated PPARδ nuclear hormone receptor interaction with SRCPs. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human ADRA2B β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human ADRA2B β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure ADRA2B (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical 23-cGAMPsodIum salt 500ug
A second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA; contains a non-canonical 2’5’-phosphodiester bond; binds tightly to the adapter protein STING (Kd = 3.79 nM) and induces IFN-β mRNA expression (EC50 = 19.4 nM in L929 cells)