General Cell Based Assays
Revvity Health Sciences Inc HTRF Human & Mouse Total YAP Detection Kit, 500 Assay Points
HTRF Human & Mouse Total YAP Detection Kit, 500 Assay Points
Perkin Elmer US LLC UATR Sample Position Plate - 7 mm
The PerkinElmer Universal ATR (UATR) Accessory is ideal for the general IR analysis of solids and liquids. The UATR comes in a variety of crystal configurations as well as single/multiple reflections capabilities. It produces high quality spectra through the use of a pressure arm. The pressure arm force indicator ensures sample-to-sample and operator-to-operator reproducibility. The accessory is recognized when it is placed in the spectrometer's sample compartment, the optics are automatically optimized, and the system is ready to be used without additional alignment. This UATR is compatible with the Spectrum One/100/400/65 and Spectrum 3/Frontier spectrometers.
Eurofins Discoverx PathHunter eXpress GPR37L1 CHO-K1 β-Arrestin Orphan GPCR Assay, 10pl Kit. (93-0378E2ACP1L)
The PathHunter GPR37L1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR37L1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR37L1 and EA-tagged β-Arrestin-2. Activation of GPR37L1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cell Biolabs Inc Total Cholesterol Assay Kit (Colorimetric), 192 assays
Cell Biolabs’ Total Cholesterol Assay Kit is a simple colorimetric assay that measures the amount of total cholesterol present in plasma, serum, tissue homogenates, or cell lysates in a 96-well microtiter plate format. The assay will detect total cholesterol (cholesteryl esters plus free cholesterol) in the presence of cholesterol esterase or only free cholesterol in the absence of the esterase enzyme. Each kit provides sufficient reagents to perform up to 192 assays, including blanks, cholesterol standards and unknown samples. Sample cholesterol concentrations are determined by comparison with a known cholesterol standard. Cholesteryl esters can be quantified by subtracting the free cholesterol values from the total cholesterol value.
Cayman Chemical HS MInral OIl asy Reagent 15mL
A kainate receptor agonist induces currents in Xenopus oocytes expressing homomeric GluR5 or GluR2 subunit-containing receptors (EC50s 0.16 and 0.23 UM respectively) induces desensitization in HEK293 cells expressing homomeric GluR6 subunit-containing kainate receptors at 0.03-0.3 UM selectively binds to the kainate receptor (IC50 ~0.035 UM) over the AMPA and NMDA receptors (IC50s >100 and 7 UM respectively) but does bind to EAAT2 (Kb 3.4 UM) and inhibits glutamate transport reduces hind paw withdrawal frequency and increases withdrawal latency to mechanical and thermal stimuli in a rat model of capsaicin-induced hyperalgesia at 10 50 and 100 mg/kg
Eurofins Discoverx PathHunter eXpress EGFR/ErbB2 Dimerization Assay, 2-Plate Kit. (93-1051E3CP14M)
The PathHunter EGFR/ErbB2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. EGF) induced dimerization of EGFR/ErbB2 receptors. This product uses EFC technology. The cell line included overexpresses ErbB2 target protein fused to PK alongside EGFR target protein fused to EA. Upon ligand-induced dimerization of EGFR/ErbB2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cytek Biosciences Inc Cell Cycle Kit Amnis
Product Name: Muse Cell Cycle Kit
Cytek Catalog Number: MCH100106
Product Class: Guava Muse Reagent
Type: Muse
Size: 100 Tests
Eurofins Discoverx PathHunter Mouse MDC (CCR4) β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse MDC (CCR4) β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mCCR4 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
ACROBiosystems Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human, 10000 tests
Human Fc gamma RIIIA / CD16a (F176) binding Kit (TR-FRET) is expressed from Human
Eurofins Discoverx cAMP Hunter eXpress RXFP3 (SALPR) CHO-K1 GPCR Assay, 2-Plate Kit. (95-0102E2CP2M)
The cAMP Hunter RXFP3 (SALPR) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. relaxin-3) based activation of RXFP3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type RXFP3, a naturally Gi/Go coupled GPCR. Upon activation of RXFP3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Enzo Life Sciences Matrix metalloproteinase-3 (MMP-3) fluorometric drug discovery kit, GREEN (1x96wells)
The MMP-3 Fluorometric (also known as fluorimetric)Drug Discovery Kit, GREEN is a complete assay system designed to screen MMP-3 inhibitors using a quenched fluorogenic MMP-3 substrate: 5-FAM-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(TQ2W)-NH2 [5-FAM=5-carboxyfluorescein; Nva=norvaline; TQ2W=quencher]. FAM fluorescence is thoroughly quenched by the TQ2W group until cleavage by MMPs separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-3, a potential therapeutic target. The compound NNGH is also included as a prototypic control inhibitor. Alternative name: Stromelysin 1, Transin 1. Applications: Fluorescent detection, HTS Activity assay.
Enzo Life Sciences Matrix Metalloproteinase-14 (MMP-14) fluorometric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-14 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-14 (MMP-14, membrane-type matrix metalloproteinase 1, MT1-MMP) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. Also included are active enzyme, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Alternative name: Membrane type matrix metalloproteinase 1, MT-1 MMP. Applications: Fluorescent detection, HTS Activity assay.
Cayman Chemical NBD-Fructose, Purity: ≥95% (sum of isomers), CAS: 940961-04-6, 1 mg
A fluorescent derivative of fructose; has been used to monitor fructose uptake by the GLUT5 transporter in MCF-7, MDA-MB-435, and MDA-MB-231 human breast cancer cells; ex/em = 472/538 nm, respectively