Protein Purification
MilliporeSigma™ Calbiochem™ PICK1 PDZ Domain Inhibitor, FSC231
The PICK1 PDZ Domain Inhibitor, FSC231 controls the biological activity of PICK1. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ NBD-Binding Peptide II, Cell Permeable, CTP-NBD
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50∽ 50μM in HCT116 cells).
MilliporeSigma™ Calbiochem™ Bortezomib
Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.
MilliporeSigma™ Calbiochem™ Fn14 Antagonist, L524-0366
Specifically binds to the Fn14 surface (Kd = 7.12 mM) and suppresses TWEAK-induced glioma cell migration.
MilliporeSigma™ Calbiochem™ β-Catenin/Tcf Inhibitor VI, ICG-001
A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25μM) and in mice in vivo (5mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE c
MilliporeSigma™ Calbiochem™ MMP-13 Substrate, Fluorogenic
A quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 106 M-1 s-1).
MilliporeSigma™ Calbiochem™ Apicidin, Fusarium sp.
A potent, cell-permeable inhibitor of histone deacetylase (IC50 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties.
MilliporeSigma™ Calbiochem™ PON1 Activator, ZNPA
The PON1 Activator, ZNPA modulates the biological activity of PON1. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ Glutaminase Inhibitor II, BPTES
A cell-permeable, potent, selective, reversible, and uncompetitive allosteric inhibitor of kidney-type glutaminase (GLS1). Does not affect the activity of liver glutaminase.
MilliporeSigma™ Calbiochem™ Erastin
A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.
MilliporeSigma™ Calbiochem™ Neuronal Differentiation Inducer III
A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells.
MilliporeSigma™ Calbiochem™ Cdk4 Inhibitor III
The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ SOD1 Inhibitor, LCS-1
The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.