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A direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 (IC50 = 1 μM); no known significant effect on the activity of a range of other kinases; promotes cell detachment and inhibits cell adhesion of cells in culture; blocks tumor growth in vivo
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An inhibitor of bacterial β-glucuronidase (IC50 = 283 nM for the E. coli enzyme); inhibits wild-type but not Δ360-376 E. coli β-glucuronidase at 100 µM; reduces irinotecan-induced colonic epithelial damage and the number of bloody diarrheal events in a mouse model of chemotherapy-induced intestinal toxicity at 50 mg/kg
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes; cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More