Protein Purification
Cayman Chemical PAD2 InhIbItr Screeng as 96Wel
PAD2 is a guanidino-modifying enzyme that catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. This enzyme has been implicated in several diseases, including rheumatoid arthritis (RA), retinal degeneration, and certain cancers. PAD2 has been shown to modify vimentin, fibrinogen, and β/γ-actin. Extracellular levels of PAD2 are increased in the lungs of smokers, providing a link between smoking as a risk factor for RA and anti-citrullinated protein antibodies among RA patients. Cayman's PAD2 Inhibitor Screening Assay Kit (AMC) provides a convenient method for screening human PAD2 inhibitors.
Med Vet International Dynarex Disposable Water Trap, Y Cap, Use w/22 mm Tubing, 60 Cc, Pediatric, 50/Case
The Dynarex Resp-O2™ Disposable Water Trap is designed to seal off excess moisture and gasses during oxygen therapy and prevent them from backing up into tubing. The Water Trap features a threaded collection jar and self-sealing Y-shaped lid to ensure that circuits remain clear and unobstructed. Designed to trap liquids and help prevent obstructions in corrugated/circuit tubing Features threaded jar and Y-sealing lid to ensure uninterrupted flow Constructed from high-quality plastic materials for optimal reliability Not made with natural rubber latex or DEHP Available in Adult (accepts 22mm tubing) and Pediatric (accepts 15mm tubing) sizes
Biolegend MojoSort™ Human B Cell (CD43-) Isolation Kit
MojoSort™ Human B Cell (CD43-) Isolation Kit Reactivity: Human; Apps: Cell Sep - Neg; Size: 20 tests
AdipoGen AMPAdePi
Protein. Full-length NAD 5’-nucleotidase Haemophilus influenzae without the signal peptide corresponding to the first 26 aa. Source E. coli. Endotoxin content N/A. Liquid. In 5mM KH2PO4, pH 6.8 containing 100mM TRIS-HCl pH 8.5 and 10mM MgCl2. Purity >98% SDS-PAGE. NadN NAD nucleotidase is a periplasmic enzyme from Haemophilus influenzae, a major pathogen of the respiratory tract in humans that has developed the capability to exploit host NADP for its nicotinamide dinucleotide requirement. NadN plays a central role by degrading NAD into adenosine and NR nicotinamide riboside, NMN to nicotinamide riboside and AMP to adenosine. It shows a broad substrate specificity, recognizing either mono- or di-nucleotide nicotinamides and different adenosine phosphates with a maximal activity on 5-adenosine monophosphate. It can be used as an economically alternative to produce NR nicotinamide riboside. Catalytic activity NAD=AMP NMN=AdeNRPPi
AdipoGen NADK cat-domh His
Protein. Human NAD kinase aa 64-446 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Free of any nucleotide converting side-activities. Liquid. Ammonium sulphate suspension. Purity >95% SDS-PAGE. NAD kinase catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis.
AdipoGen DNER ED h rec
Protein. Signal peptide and extracellular domain of human DNER aa 1-640 are fused at the C-terminus with a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS 0.02% CHAPS. Purity >90% SDS-PAGE. DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
Biolegend MojoSort™ Mouse Neutrophil Isolation Kit
MojoSort™ Mouse Neutrophil Isolation Kit Reactivity: Mouse; Apps: Cell Sep - Neg; Size: 100 tests
Active Motif ChIP-IT High Sensitivity
The ChIP-IT High Sensitivity (HS) Kit is designed to give superior performance when performing ChIP using antibodies against low abundance transcription factors, antibodies with sub-optimal binding affinities or when starting with a limited number of cells. Higher signal and lower non-specific DNA pulldown is achieved through the incorporation of specialized protein G agarose beads and optimized fixation, binding and wash buffers. In addition, washes are performed via gravity filtration, which is faster, easier and more consistent than magnetic bead capture. The high-quality ChIP DNA obtained from the ChIP-IT High Sensitivity Kit is also ideal for ChIP-Seq; ChIP-IT HS has been validated for use in this application, even when using antibodies that target low abundance transcription factors.
Cayman Chemical 8Isoprostn AffInIty PurIfI 5ea
This kit contains all reagents necessary for simple one-step purification of 8-isoprostane from most biological samples.
Cayman Chemical GST Sample Buffer2X 1ea
An alkaloid with anti-inflammatory activity reduces LPS-induced TNF-a release from and NO production in RAW 264.7 macrophages at 10 30 and 100 UM reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
Cayman Chemical PI4KIII InhIbItr 3 5mg
An inhibitor of PI4KIIIβ (IC50 = 19 nM); ~100-fold selective for PI4KIIIβ over PI4KIIα, PI4KIIβ, and PI4KIIIα, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, and PI3KC3, as well as 100-500-fold selective over PI3KC2α, PI3KC2β, and PI3KC2γ