Protein Purification
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor II
A cell-permeable hydroxynaphthalenylthioacetate that targets Mcl-1 BH3-binding groove and selectively competes against 8nM FITC-AHA-BIM142-161 for Mcl-1, but not Bcl-xL, binding (IC50 = 310nM vs >40μM; [Mcl-1] & [Bcl-x
MilliporeSigma™ Calbiochem™ HBDDE
A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKCα and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays.
MilliporeSigma™ Calbiochem™ UCH-L1 Inhibitor
The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Hsp25 Kinase Inhibitor
The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ TIRAP Inhibitor Peptide, Cell-Permeable
The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ InSolution™ γ-Secretase Inhibitor X
InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC50 = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).
MilliporeSigma™ Calbiochem™ Hh/Gli Antagonist, GANT58
The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ InSolution™ Paclitaxel, Taxus sp.
Antitumor and anti-leukemic agent isolated from the bark of the yew tree
MilliporeSigma™ Calbiochem™ Aniracetam
A positive allosteric modulator selective for AMPA receptors
MilliporeSigma™ Calbiochem™ PKCθ/δ Inhibitor
A cell-permeable pyridinecarbonitrile compound that acts as a potent, ATP-competitive (Ki = 79 nM, using PKCθ KD in coupled PK/LDH assays), and isozyme-selective PKCθ inhibitor (IC50 = 70nM) with much reduced potency against other novel PKCs (IC50
MilliporeSigma™ Calbiochem™ HA 1077, Dihydrochloride
A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties.
MilliporeSigma™ Calbiochem™ PKCε Peptide Substrate
Pseudosubstrate region of the ε-isotype of protein kinase C (PKCε
MilliporeSigma™ Calbiochem™ PDGFR Tyrosine Kinase Inhibitor IV
A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33
MilliporeSigma™ Calbiochem™ Aminopeptidase N/CD13 Inhibitor
The Aminopeptidase N/CD13 Inhibitor controls the biological activity of Aminopeptidase N/CD13. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ Cdc42/Rac1 Dual Inhibitor, AZA1
A cell-permeable compound that suppresses upregulation of GTP-bound Rac1 and Cdc42. Inhibits prostate cancer cells migration by decreasing cellular F-/G-actin ratio.