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An inhibitor of GRK2/βARK1 (IC50 = 126 µM); selective for GRK2/βARK1 over PKA at concentrations up to 1 mM; decreases systolic blood pressure in ob/ob and nicotinamide plus streptozotocin-induced mouse models of type 2 diabetes at 200 UG/kg; improves clonidine-induced relaxation of precontracted isolated aortic rings and improves glucose tolerance in the ob/ob mouse model; inhibits serotonin- or neurotensin-induced DIR in the rat ventral tegmental area in vitro
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The GenScript Anti-DYKDDDDK G1 Affinity Resin is designed for the efficient purification of DYKDDDDK-tagged proteins from various expression systems such as bacteria, yeast, and mammalian cells. This affinity resin utilizes a high-affinity mouse monoclonal antibody coupled to 4% cross-linked agarose beads, allowing for specific protein capture while minimizing non-specific binding. It supports multiple elution methods and is ideal for both purification and immunoprecipitation applications.
High specificity and capacity for clean protein isolation
Versatile elution options for various protein characteristics
Compatible with bacteria, yeast, and mammalian cell systems
Reusable for up to 10 times with proper maintenance
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Nickel Agarose Resin is available in bulk or in prepacked columns. It has a binding capacity of >25 mg/ml with approximately 60 kDa protein. In addition, it allows for purification of proteins under native or denaturing conditions. GoldBio Nickel Agarose works very well with the His-Tag Buffer Set.
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The Protein G-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of protein G. The beads can be used to capture the antibodies in Chemiluminescence procedures.The Protein G binds the heavy chain within the Fc region of most immunoglobulins but not bind dog immunoglobulins.The Protein G-coupled Magnetic Beads is easy to capture the most antibodies, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.
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A pyrimidine dicarboxamide that selectively inhibits MMP-13 (IC50 = 8 nM); blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification
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