Protease Inhibitors and Phosphatase Inhibitors
Abcam Protease Inhibitor Cocktail EDTA Free (100 x ), 3ML
Protease inhibitor cocktail EDTA free (100X) protects protein extracts from aminopeptidases, metalloproteases, and serine, cysteine, and aspartic acid proteases. - Suitable for protease inhibition during protein extraction from mammalian tissues and cells, yeast and fungal cells, and bacteria - 100X stock solution of protease inhibitors dissolved in DMSO - Does not contain the chelating agent EDTA
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC RIP1 kinase inhibitor 1 | 2095515-38-9 | 100.0% | 461.90 | 10 MG
RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04). It strongly suppresses necroptotic cell death and phosphorylation of MLKL (pMLKL) in human colorectal adenocarcinoma HT-29 cells (necroptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (necroptosis, IC50=15 nM; pMLKL, IC50=2.7 nM).
- Highly potent RIP1 kinase inhibitor
- Orally available
- Brain-penetrating
- Suppresses necroptotic cell death
- Suppresses phosphorylation of MLKL (pMLML)
Selleck Chemical LLC Bortezomib (PS-341) 100mg 179324-69-7 LDP-341, MLM341
Bortezomib (PS-341, LDP-341, MLM341) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-?B and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical Src KInase InhIbItr I 10mg
A potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes; also inhibits RIP-2
Bioworld Protease inhibitor Cocktail V Animal Free EDTA-Free, 1 Vial(s)
Lyophillized blend of four protease inhibitors for use in applications that require animal free reagents. Reconstitute with lml water to produce a 100X concentrated solution.* Contains: AEBSF, Aprotinin (recombinant), E-64, Leupeptin,* Specificity: Serine Proteases, Cysteine Proteases, and Trypsin like ProteasesUsually ships within 24 hours.This product is sold for research use only.
Sigma Aldrich Fine Chemicals Biosciences NAV-2729 >=98% (HPLC) | 419547-11-8 | MFCD01455625 | 5MG
NAV-2729 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 456.88 | 419547-11-8 | MFCD01455625 | 5MG
Abcam SF1670, PTEN inhibitor, 5MG
MW 307.3 Da, Purity >98%. Selective PTEN inhibitor (IC₅₀ = 2 μM). Elevates intracellular PIP3 signaling. Reduces neutrophil functions, including phagocytosis, oxidative burst, polarization, and chemotaxis. Active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Reversan, MRP1 and P-glycoprotein inhibitor, 50MG
MW 441.53 g/mol, Purity >99%. Selective MRP1 and P-glycoprotein inhibitor. Chemosensitizing agent. Increases the sensitivity of MRP1-overexpressing tumor cells to doxorubicin (ab120629), vincristine (ab120226) and etoposide (ab120227). Shows chemosensitizing, antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences SB-216763 (1mg). CAS: 280744-09-4
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>25mg/ml). Long Term Storage: Ambient.
Abcam PD 168393, EGFR inhibitor, 1MG
MW 369.2 Da, Purity >98%. Potent, irreversible, cell-permeable, selective EGFR inhibitor (IC₅₀ values are 0.7, 0.08, 5.7, 12 and 15 nM for EGF receptor tyrosine kinase, erbB1, erbB2, erbB4 and SK-BR-3, respectively). Binds to the catalytic domain. Inhibits cancer cell growth. Blocks reactive astrogliosis and shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical HAT InhIbItr II 1mg
A cell-permeable, selective inhibitor of the HAT p300 (IC50 = 5 µM)
CPC Scientific Ac-Tyr-Val-Ala-Asp-CMK 0.5MG
Irreversible inhibitor of caspase-1 (ICE) that has also been shown to be a potent therapeutic agent against in vivo liver apoptosis in mice.ONE-LETTER SEQUENCE: Ac-YVAD-CMKMOLECULAR FORMULA: C24H33N4O8Cl1MOLECULAR WEIGHT:541STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [178603-78-6], RESEARCH AREA: ApoptosisREFERENCES: J. B. Schulz et al., J Neurosci, 16, 4696 (1996); N.P.C. Walker et al., Cell 78, 343 (1994)
Cayman Chemical EGFR InhIbItr 25mg
A cell permeable, selective inhibitor of the EGFR kinase (IC50s = 21, 63, and 4 nM for EGFR and the L858R and L861Q EGFR mutants, respectively)
Cayman Chemical Mpro InhIbItr 11b 10mg
An inhibitor of Mpro (IC50 = 0.04 µM in a TR-FRET assay); reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50 = 0.72 µM); reduces viral RNA copy numbers in the same model from 1.85-50 µM
Echelon Biosciences Research Labs BODIPY TMR - PTDINS(4)P 50 ug
BODIPY TMR PI(4)P (BODIPY TMR Phosphatidylinositol 4-phosphate) is a water soluble analog of PI(4)P labeled with the orange fluorophore, Bodipy-TMR, at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable