Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ (+)-Abscisic Acid
An isoprenoid plant hormone that acts as a growth regulator affecting leaf and fruit abscission and increases permeability of plant cells to water.
MilliporeSigma™ Calbiochem™ TRPM Antagonist, M8-An
A cell-permeable, readily bioavailable 2-picolinamide derivative that acts as a highly potent antagonist of transient receptor potential cation channel subfamily M member 8 (TRPM8; IC50 =
MilliporeSigma™ Calbiochem™ CFTR Potentiator, VX-770
A cell-permeable, potentiator of CFTR that directly, reversibly, and allosterically binds to WT and G551D mutant forms (≈10 μM) and increases the open probability to restore lung function.
MilliporeSigma™ Calbiochem™ TRPV4 Agonist, GSK1016790A
A cell-permeable, potent, selective agonist of TRPV4 channel. Enhances Ca2+ flux in a variety of human and mouse cells (EC50 = 2.1 nM for human TRPV4).
MilliporeSigma™ Calbiochem™ PP1 Analog II, 1NM-PP1
PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases.
MilliporeSigma™ Calbiochem™ Protease Arrest™ Reagent
An optimized concentration of various reversible and irreversible inhibitors to inhibit serine, cysteine, and calpain proteases.
MilliporeSigma™ Calbiochem™ PFKFB3 Inhibitor III, YN1
A cell-permeable, potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 670 nM).
MilliporeSigma™ Calbiochem™ Luciferase Substrate, CycLuc1
A synthetic cyclic alkylaminoluciferin with properties superior to D-luciferin. Binds to luciferase with higher affinity.
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MilliporeSigma™ Calbiochem™ Proteasome Substrate II, Fluorogenic
Fluorogenic proteasome substrate.
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set VII
Protease Inhibitor Cocktail Set VII contains five protease inhibitors with broad specificity. Recommended for purification of proteins containing His·Tag™ sequences.
MilliporeSigma™ Calbiochem™ AEBSF, HCl ≥99% by HPLC
Specific irreversible inhibitor of serine proteases
MilliporeSigma™ Calbiochem™ Beclin-1 Activator I, TAT-Beclin-1, Scrambled
A randomly shuffled Beclin-1 (267-284) peptide made cell-permeable by covalently attaching to HIV-1 Tat protein transduction domain via a diglycine linker
MilliporeSigma™ Calbiochem™ Protease Inhibitor Cocktail Set I
A cocktail of five protease inhibitors that will inhibit a broad range of proteases and esterases. Supplied with a data sheet.
MilliporeSigma™ Calbiochem™ PTP1B Inhibitor
PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 μM and 8 μM for PTP1B403 and PTP1B298, respectively).
MilliporeSigma™ Calbiochem™ Akt Inhibitor II
The Akt Inhibitor II controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.