Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ CFTR Inhibitor-172
CFTR Inhibitor-172, CAS 307510-92-5, is a cell-permeable, potent, reversible, rapid, and voltage-independent inhibitor of CFTR-mediated Cl- transport in human airway cells (Ki ≈300 nM).
MilliporeSigma™ Calbiochem™ UCH-L1 Inhibitor
The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Cathepsin D/E Substrate, Fluorogenic
An internally quenched fluorogenic 11-mer peptide that acts as a sensitive and selective substrate for cathepsins D and E, but not cathepsins B, H, or L .
MilliporeSigma™ Calbiochem™ Cathepsin L Inhibitor I
The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Cathepsin B Substrate III, Fluorogenic
Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.
MilliporeSigma™ Calbiochem™ Glucokinase Activator II
A cell-permeable compound that reduces glucokinase Km for glucose (EC50 = 120 nM & 350 nM, for human and rat enzyme). Enhances insulin secretion from INS-1 cells upon glucose exposure.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor XVIII, BP-1-102
The STAT3 Inhibitor XVIII, BP-1-102 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Autophagy Inhibitor IV, Cpd18
A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K
MilliporeSigma™ Calbiochem™ Riluzole
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1
A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) c
MilliporeSigma™ Calbiochem™ Combretastatin A-4
A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization as well as cellular microtubule assembly
MilliporeSigma™ Calbiochem™ InSolution™ OM99-2
An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
MilliporeSigma™ Calbiochem™ Diclofenac Sodium
A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.
MilliporeSigma™ Calbiochem™ Transglutaminase 2 Inhibitor II, ERW1041E
A cell-permeable, active-site directed, acyl-donor substrate competitive inhibitor of transglutaminase 2 (TG2, Ki = 11 μM).
MilliporeSigma™ Calbiochem™ Hsp25 Kinase Inhibitor
The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.