Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Proteinase K Inhibitor
Proteinase K Inhibitor is a tetrapeptidyl chloromethyl ketone compound that acts as an active-site-targeting irreversible inhibitor against proteinase K.
MilliporeSigma™ Calbiochem™ Emodin
A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 μM).
MilliporeSigma™ Calbiochem™ eIF-2α Inhibitor II, Sal003
The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Apoptosis Activator III, Embelin
The Apoptosis Activator III, Embelin, also referenced under CAS 550-24-3, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ InSolution™ Src Inhibitor, PP1
The InSolution™ Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Troponin Activator, CK-2017357
Directly and selectively binds to the troponin complex in fast skeletal muscle (Kd = 40 nM) and sensitizes it to calcium.
MilliporeSigma™ Calbiochem™ Mycophenolic Acid
An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.
MilliporeSigma™ Calbiochem™ p38 MAP Kinase Inhibitor III
The p38 MAP Kinase Inhibitor III, also referenced under CAS 581098-48-8, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ LSD1 Inhibitor II, S2101
The LSD1 Inhibitor II, S2101 controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ Dihydroorotate Dehydrogenase Inhibitor, Brequinar
An immunosuppressive and anti-neoplastic agent that inhibits pyrimidine synthesis by blocking the activity of mammalian mitochondrial dihydroorotate dehydrogenase (DHODH; IC50 = 12 nM).
MilliporeSigma™ Calbiochem™ Proteasome Substrate III, Fluorogenic
Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin.
MilliporeSigma™ Calbiochem™ ET-18-OCH3
A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.
MilliporeSigma™ Calbiochem™ Protein Lysine Methyltransferase Inhibitor, UNC0321
A cell-permeable, quinazoline analog that potently and selectively inhibits PKMT G9a (IC50 = 6nM and 9nM in two biochemical assays for CLOT and ECSD, respectively, and Ki = 63 pM, which is approximately 250-fold more potent than a closely-related analog, BIX0129
MilliporeSigma™ Calbiochem™ CD45 Inhibitor VI
A cell-permeable, potent, irreversible, non-substrate competitive inhibitor of CD45/PTPRC tyrosine phosphatase activity (IC50 = 290 nM).
MilliporeSigma™ Calbiochem™ Cyclopamine, V. californicum
Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.