Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ N-Methyl-D-aspartic Acid, Hydrate
Excitatory amino acid neurotransmitter.
MilliporeSigma™ Calbiochem™ Okadaic Acid, Potassium Salt
Water-soluble analog of Okadaic Acid. Inhibits protein phosphatases 1 and 2A.
MilliporeSigma™ Calbiochem™ MEK Inhibitor Set
The MEK Inhibitor Set controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ MG-132 in EtOH, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
MilliporeSigma™ Calbiochem™ Myricetin
A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties.
MilliporeSigma™ Calbiochem™ MK-886
A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO pathway activation by inhibiting FLAP, rather than 5-LO, activity.
MilliporeSigma™ Calbiochem™ Cypermethrin
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.
MilliporeSigma™ Calbiochem™ mTOR Kinase Inhibitor II, WYE-354
The mTOR Kinase Inhibitor II, WYE-354, also referenced under CAS 1062169-56-5, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Hydroxyfasudil
A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties.
MilliporeSigma™ Calbiochem™ Hydroxyurea
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
MilliporeSigma™ Calbiochem™ γ-Secretase Inhibitor XX
This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ≈72% in Tg2576 mutant APP transgenic mouse model.
MilliporeSigma™ Calbiochem™ SU1498
A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.
MilliporeSigma™ Calbiochem™ Staurosporine, Streptomyces sp.
Staurosporine, CAS 62996-74-, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinases (IC50 = 7, 20, 1.3, 0.7, & 8.5 nM for PKA, CAMK, MLCK, PKC, & PKG, respectively).
MilliporeSigma™ Calbiochem™ Nifedipine
Relatively selective blocker of L-type Ca2+ channels.
MilliporeSigma™ Calbiochem™ α-Naphthyl Acid Phosphate, Monosodium Salt
α-Naphthyl Acid Phosphate, Monosodium Salt - CAS 81012-89-7, is a broad-spectrum protein phosphatase inhibitor.