Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Rho Inhibitor II, Y16
A cell-permeable pyrazolidinedione compound that is shown to target RhoGEF DH-PH domain junction with high affinity (Kd = 65nM) and effetively prevent RhoGEFs LARG, p115, and PDZ from interacting with RhoA, while displaying little potency against DBL-RhoA, LBC-RhoA, intersectin-Cdc42, or TrioN-Cdc42 interact
MilliporeSigma™ Calbiochem™ InSolution™ p38 MAP Kinase Inhibitor III
The InSolution™ p38 MAP Kinase Inhibitor III controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ G-Protein βγ Binding Peptide, mSIRK
A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.
MilliporeSigma™ Calbiochem™ InSolution™ SU5402
Inhibits the tyrosine kinase activity of FGFR1 (IC50 = 10-20μM in the presence of 1mm ATP) by interacting with the catalytic domain of FGFR1
MilliporeSigma™ Calbiochem™ Daidzein
Inactive analog of Genistein.
MilliporeSigma™ Calbiochem™ PAF Receptor Antagonist, ABT-491
The PAF Receptor Antagonist, ABT-491, also referenced under CAS 189689-94-9, controls the biological activity of PAF Receptor. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ Akt Inhibitor
The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Kir6.2/SUR1 Channel Activator, VU0071063
A fast acting, reversible, and selective activator of Kir6.2/SUR1 channels (EC50 = 7 μM).
MilliporeSigma™ Calbiochem™ PDK1/Akt/Flt Dual Pathway Inhibitor
The PDK1/Akt/Flt Dual Pathway Inhibitor, also referenced under CAS 331253-86-2, controls the biological activity of PDK1/Akt/Flt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Loperamide Hydrochloride
A very potent and highly selective peripheral resctrictedμ-opioid receptor agonist (Ki = 2
MilliporeSigma™ Calbiochem™ ETV1 Inhibitor, BRD32048
Cell-permeable, reversibly binds to ETV1 (KD = 17.1 μM) and reduces its transcriptional activity, independent of its binding to DNA.
MilliporeSigma™ Calbiochem™ InSolution™ MG-132 in EtOH, ≥95% by HPLC
Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.
MilliporeSigma™ Calbiochem™ LRRK2 Inhibitor II, CZC-25146
The LRRK2 Inhibitor II, CZC-25146 controls the biological activity of LRRK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Cathepsin D Substrate I
Useful as a substrate for the determination of cathepsin D activity.
MilliporeSigma™ Calbiochem™ Phospholipase C Activator, m-3M3FBS
The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.