Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Cdk4 Inhibitor III
The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ NMD Inhibitor
A cell-permeable inhibitor of nonsense-mediated mRNA decay (NMD) that enhances the stability of premature termination codon mutated p53 mRNA in N417 and HDQP-1 cells.
MilliporeSigma™ Calbiochem™ InSolution™ Wortmannin
Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase).
MilliporeSigma™ Calbiochem™ Gβγ Modulator II, Gallein
A cell-permeable xanthene compound that binds to Gβγ with high affinity (K
MilliporeSigma™ Calbiochem™ RAF Kinase Inhibitor VII
A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out confor
MilliporeSigma™ Calbiochem™ Caspase-2 Inhibitor I
The Caspase-2 Inhibitor I controls the biological activity of Caspase-2. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ MMP-2 Inhibitor II
The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor, MIM1
A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL , antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50
MilliporeSigma™ Calbiochem™ Simvastatin, Sodium Salt
Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.
MilliporeSigma™ Calbiochem™ Muscimol
Muscimol is a constituent and psychoactive ingredient of the mushroom Amanita muscaria, that acts as a potent agonist of GABAA receptors.
MilliporeSigma™ Calbiochem™ Acidic Mammalian Chitinase Inhibitor, Bisdionin F
The Acidic Mammalian Chitinase Inhibitor, Bisdionin F controls the biological activity of Acidic Mammalian Chitinase.
MilliporeSigma™ Calbiochem™ Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700
The Ras Superfamily GTPases GTP/GDP Binding Antagonist, CID 1067700 controls the biological activity of Rab7. This small molecule/inhibitor is primarily used for Membrane applications.
MilliporeSigma™ Calbiochem™ Celastrol, Celastrus scandens
A cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties.
MilliporeSigma™ Calbiochem™ IKKε/TBK1 Inhibitor II, MRT67307
A cell-permeable, potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKKε (IC50 = 19 and 160 nM, respectively).
MilliporeSigma™ Calbiochem™ BMP-2 Signaling Enhancer, A01
Enhances BMP-2 associated signaling by inhibiting Smurf1-mediated Smad1/5 ubiquitination and thereby prolonging the half-life of Smad1 and 5. in 48 h).