Testing systems, controls, reagents, and other products for used to calibrate clinical drug tests, identify drugs of abuse in patient samples, and monitor patients receiving drug therapy.
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A covalent inhibitor of PME-1 (IC50 0.6 UM) reduces the levels of methylated PP2A in HEK293T cells stably overexpressing PME-1 at 20 UM. AMZ30 inhibits t-BHP-induced decreases in U87MG and U-251MG cells at 210 UM
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A liminoid degradant has antifeedant activity against and inhibits development of armyworm larvae when applied to fresh wheat leaves at 5 10 or 20 mg/ml reduces LPS-induced nuclear translocation of the NF-KB subunit p65 as well as inhibits LPS-induced production of NO and PGE2 in RAW 264 7 cells reduces tumor growth in an A549 mouse xenograft model at 30 or 100 mg/kg
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A chalcone and flavonoid with diverse biological activities inhibits a-glucosidase UGT1A1 and UGT1A7 (IC50s 11 1 11 3 and 3 6 UM respectively) cytotoxic to K562 cells (IC50 2 77 UM) inhibits RANKL-induced osteoclastogenesis of isolated mouse BMDMs at 5 Ug/ml
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A liminoid degradant has antifeedant activity against and inhibits development of armyworm larvae when applied to fresh wheat leaves at 5 10 or 20 mg/ml reduces LPS-induced nuclear translocation of the NF-KB subunit p65 as well as inhibits LPS-induced production of NO and PGE2 in RAW 264 7 cells reduces tumor growth in an A549 mouse xenograft model at 30 or 100 mg/kg
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A degradation product of panaxatriols cytotoxic to P388 L1210 and K562 leukemia cells (EC50s 34 32 and 38 UM) inhibits EGFR (IC50 24.1 UM) in a cell-free assay cytotoxic to HepG2 cells from 20-100 UM
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An active metabolite of spironolactone decreases plasma testosterone and estradiol levels in male dogs at 100 mg/kg reduces mercuric chloride-induced nephrocalcinosis and mortality in rats
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An activator of the STING pathway induces secretion of IFN-B in human PBMCs (EC50 130 nM) increases serum levels of Ifn-B Il-6 Tnf and Cxcl1 in wild-type but not Sting-/- mice at 2.5 mg/kg inhibits the cytopathic effect of HCoV-229E in infected MRC-5 cells (EC50 3 nM) decreases the level of SARS-CoV-2 RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay decreases tumor volume and increases survival in a CT26 murine colorectal cancer model at 3 mg/kg this compound is expected to exist in one or both tautomeric forms
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Lipid CP-LC-1428 is an ionizable cationic amino lipid derived from homocysteine a naturally occurring amino acid. This lipid has demonstrated an efficient delivery and high protein expression of different kinds of RNA (mRNA cRNA and saRNA)in vivo. Moreover using a typical LNP formulation (IL/Ch/DOPE/PEG 50/38.5/10/1.5) it has shown to induce specific spleen targeting much more efficiently that other commercial alternatives throUGh IV injection with no signs of toxicity.
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An ionizable cationic lipid has been used in the generation of LNPs for the delivery of mRNA in vivo LNPs containing 119-23 and encapsulating an mRNA reporter show greater intramuscular transfection efficacy compared to LNPs containing SM-102 or DLin-MC3-DMA in mice 119-23-containing LNPs accumulate in mouse hepatic and splenic immune cells to a greater extent than SM-102-containing LNPs LNPs containing 119-23 and encapsulating mRNA encoding hEPO increase serum hEPO levels in mice
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