Other Controls and Reagents
Medchemexpress LLC Dspe-peg2000-crgdkgpdc (disulfide bridge:Cys1-Cys9) | 95.0% | 2000 (Average) | 25 MG
DSPE-PEG2000-iRGD is a PEG compound composed of DSPE and an αv-integrins targeting peptide (iRGD). The iRGD peptide binds to αv-integrins and is then proteolytically cleaved in the tumor to produce CRGDK/R, which interacts with neuropilin-1. This compound has tumor-targeting and tumor-penetrating properties and can be used for agent delivery.
- Irgd peptide binds to αv-integrins.
- Proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1.
- Possesses tumor-targeting and tumor-penetrating properties.
- Can be used for agent delivery.
- Used to construct nanomicelles for targeted delivery of salinomycin to intervene in liver cancer cells and cancer stem cells.
- Used to construct a tumor-penetrating peptide liposome that exhibits antitumor effects, including a significant reduction in tumor volume and an increase in body weight and spleen index.
Cayman Chemical 1 2-DIoleoyl-sn-glycerol 25mg
An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm
Medchemexpress LLC Glyco-diosgenin | 1402423-29-3 | >=97% | 1165.31 g/mol | 5 MG
Glyco-diosgenin (GDN) is a synthetic drop-in substitute for Digitonin. It is intended for research use only and not for use in human, therapeutic, or diagnostic applications. All products should be handled by qualified personnel trained in laboratory procedures.
- Purity (HPLC): ≥97%
- Supplied as a powder
![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium | 474922-22-0 | 95.0% | 2000 (Average) | (C2H4O)nC51H92N1O13P.H3N | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000221558.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] ammonium | 474922-22-0 | 95.0% | 2000 (Average) | (C2H4O)nC51H92N1O13P.H3N | 5 MG
DSPE-PEG2000-Maleimide (ammonium) is a PEGylated phospholipid composed of DSPE linked to a polyethylene glycol chain (average MW 2000) terminating in a maleimide group. The maleimide functionality enables selective conjugation to thiol-containing molecules, making this reagent useful for creating functionalized liposomes, nanostructured lipid carriers, and surface-modified nanoparticles. The PEG chain improves colloidal stability and extends circulation time.
- Thiol-reactive maleimide end for selective covalent conjugation.
- PEG2000 chain increases circulation time and colloidal stability.
- Designed for liposome and nanoparticle surface functionalization.
- Typically supplied as an ammonium salt white to off-white solid.
- High purity suitable for research applications (manufacturer-specified).
Medchemexpress LLC DSPE-PEG2000-Mal-Cys-YHWYGYTPQNVI | 95.3% | 2000 (Average) | 50 MG
DSPE-PEG2000-GE11 is a nanocarrier component composed of DSPE and the EGFR-targeting peptide (GE11). It specifically binds to EGFR, mediating receptor-mediated endocytosis of micellar drug carriers for drug delivery.
- Specifically binds to EGFR.
- Mediates receptor-mediated endocytosis of micellar drug carriers.
- Enhances EGFR-dependent cellular uptake of doxorubicin (1.4-fold higher in SMMC-7721 cells).
- Inhibits HUVEC proliferation, induces G2-M phase arrest, reduces cell migration, and alters HUVEC morphology when modified.
- Enhances tumor accumulation of DiR-loaded micelles in EGFR-positive hepatocellular carcinoma xenografts.
- Confers EGFR-targeted accumulation to liposomal formulations in liver cancer xenografts.