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Control products and reagents designed for clinical testing procedures. Ideal for use in performing, calibrating, monitoring, and ensuring the accuracy of diagnostic tests such as immunoassays.
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1-Palmitoyl-sn-glycero-3-phosphocholine-d49 is the deuterium-labeled isotopologue of 1-palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC). Supplied as a solid, it is used as an analytical reference and internal standard in lipidomics and mass spectrometry workflows to enable accurate quantitation of lysophosphatidylcholine species.
Isotopically labeled with 49 deuterium atoms (d49).
Chemical formula C24HD49NO7P.
Molecular weight 544.93.
CAS number 2315262-40-7.
Supplied as a solid in small pack sizes, suitable for analytical use.
Intended for use as an internal standard in LC-MS/MS and lipid analysis.
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An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm
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An ionizable cationic lipid (pKa = 6.7); has been used in the formation of LNPs encapsulating siRNA or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-KC2-DMA selectively accumulate in the liver after i.v. or i.m. administration in mice or localize to the retinal pigment epithelium and Müller glia after subretinal administration; DLin-KC2-DMA-containing LNPs encapsulating F7-targeted siRNA reduce serum Factor VII levels in mice; DLin-KC2-DMA-containing LNPs encapsulating AR-targeted siRNA decrease serum PSA and tumor androgen receptor levels in an LNCaP prostate cancer mouse xenograft model
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An ionizable cationic lipid (apparent pKa = 6.44); has been used in the generation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, or plasmid DNA for use in vitro and in vivo; LNPs containing DLin-MC3-DMA accumulate in the muscle and non-draining lymph nodes after intramuscular administration and in the spleen after intravenous administration in mice; LNPs containing DLin-MC3-DMA and encapsulating F7 siRNA reduce hepatic and plasma Factor VII levels in mice without inducing liver toxicity
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A triacylglycerol; has been found in Kpangnana, Chinese tallow, and cocoa butters; increases the phagocytic function of reticulo-endothelial cells in mice at 5 and 10 mg per animal
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C18:1 Glucosyl(ß) Ceramide (d18:1/18:1(9Z)) is a high-purity glycosphingolipid from Avanti Polar Lipids. This ceramide consists of an oleoyl fatty acid chain and a D-erythro-sphingosine base, and is available in a 5 mg quantity. The empirical formula is C42H79NO8, with a molecular weight of 726.079, making it valuable for lipid biology research.
High-purity glycosphingolipid
Available in 5 mg quantity
Empirical formula: C42H79NO8
Molecular weight: 726.079
Lipid class: Glycosphingolipid, Ceramide
Fatty acid: 9Z-octadecenoyl (Oleoyl)
Sphingoid base: D-erythro-sphingosine (d18:1)
Physical form: Powder
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Formula Weight: 2805.497, Purity >99%, Storage Temperature: -20°C. PEG-modified lipids are typically added to phospholipid vesicles used for drug delivery to provide a steric coating on the surface of the membrane to hinder clearing of the particles by the reticuloendothelial system (RES). This prolongs the circulating plasma half-life of the drug. The plasma half-life of the drug can be "tuned" from several hours to days depending on the size of the PEG and fatty acids attached to the lipid anchor.
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