Substrates
CPC Scientific Ac-Arg-Gly-Lys(Ac)-AMC (trifluoroacetate salt) 25MG
This peptide is the fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.ONE-LETTER SEQUENCE: Ac-RGK(Ac)-AmcMOLECULAR FORMULA: C28H40N8O7MOLECULAR WEIGHT:600.68STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [660846-97-9], RESEARCH AREA: MiscellaneousREFERENCES: D.Wegener et al., Chem. Biol., 10, 61 (2003)
Apexbio Technology LLC AC-WLA-AMC-5MG
Ac-WLA-AMC (CAS No 1104011-59-7) is a compound used in biochemical research particularly within enzymology and drug discovery Originating from peptide-based substrates it functions by inhibiting specific proteases thereby impacting various biological pathways critical to disease processes It demonstrates in vitro activity in the nanomolar to low micromolar range making it effective in controlled experimental settings This compound is frequently utilized in cell models to study enzyme interactions as well as in animal studies to observe systemic biological responses Its role in drug screening is significant as it aids in identifying potential therapeutic agents through its predictable interaction with targeted enzymes Experimental concentrations typically depend on the specific research design allowing for tailored application across diverse studies
Apexbio Technology LLC AC-WLA-AMC-1MG
Ac-WLA-AMC (CAS No 1104011-59-7) is a compound used in biochemical research particularly within enzymology and drug discovery Originating from peptide-based substrates it functions by inhibiting specific proteases thereby impacting various biological pathways critical to disease processes It demonstrates in vitro activity in the nanomolar to low micromolar range making it effective in controlled experimental settings This compound is frequently utilized in cell models to study enzyme interactions as well as in animal studies to observe systemic biological responses Its role in drug screening is significant as it aids in identifying potential therapeutic agents through its predictable interaction with targeted enzymes Experimental concentrations typically depend on the specific research design allowing for tailored application across diverse studies
Sino Biological Anti-HER2 (Research Grade Pertuzumab Biosimilar) 25 mg
This product is a recombinant monoclonal antibody expressed from HEK293 cells.
Sino Biological Anti-HER2 (Research Grade Trastuzumab Biosimilar) 500 µg
This product is a recombinant monoclonal antibody expressed from HEK293 cells.
Enzo Life Sciences FLUOR DE LYS H4-AcK16 deacetylase substrate (0.5µmol)
The deacetylated state of lysine-16 of histone H4 (H4-K16) is thought to be a critical factor in determining regions of chromatin silencing. Conversely, acetylation of lysine-16 can be associated with increased transcription, such as that due to dosage compensation from the X-chromosome of male Drosophila. The acetylated H4 lysine-16 is preferentially deacetylated by yeast Sir2 in vitro and in vivo. FLUOR DE LYS-H4-AcK16 is a fluorogenic, acetylated peptide substrate suitable for various lysine deacetylases, including the HDAC activities in HeLa nuclear extract, HDAC8, SIRT1 (human Sirtuin 1) and SIRT2 (human Sirtuin 2). It is based on residues from histone H4 (12-16, Lys-Gly-Gly-Ala-Lys(Ac)) and was the preferred substrate for both SIRT1 and SIRT2 within a group patterned on acetylation sites in histone H3 and histone H4 N-terminal tails. Purity: ≥95%. Formulation: Supplied as a 5 mM solution (100 µl) in HDAC Assay Buffer.
![Research Products International Corp 4-Methylumbelliferyl-2-acetamido-2-deoxy-B-D-glucopyranoside [4-Methylumbelliferyl-N-acetyl-B-D-glucosaminide], 1 Gram](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-M64100-1.0.JPG-250.jpg)
Research Products International Corp 4-Methylumbelliferyl-2-acetamido-2-deoxy-B-D-glucopyranoside [4-Methylumbelliferyl-N-acetyl-B-D-glucosaminide], 1 Gram
Fluorescent substrate for N-Acetyl-B-D-glucosaminidase and B-N-Acetyl-D-hexosaminidase. Ultrasensitive. Checked by actual enzymatic assay.